当前位置： SCI文献检索 > JOURNAL OF INTERNAL MEDICINE期刊下所有文献 > Secondary prevention of heart disease amongst patients with lipid abnormalities: practice and trends in the United States.

Secondary prevention of heart disease amongst patients with lipid abnormalities: practice and trends in the United States.

Abstract：

:Patients with established coronary disease and abnormalities of lipid metabolism represent a particularly important subgroup, since their mortality risk is typically 10 times greater than that amongst-subjects with comparable risk factors but no clinical history. Such patients are commonly treated initially with anti-anginal therapy; if ischaemic symptoms persist they often undergo revascularization (bypass or angioplasty). While invasive procedures restore blood flow and relieve ischemia, they do not, in most cases, reduce risk of subsequent MI or death, or alter the underlying atherogenic process(es). Despite this, there has been a progressive 54% decline in age-adjusted cardiac mortality over the period 1960-1995, which appears best attributable to US lifestyle changes. In particular, the past decade has provided compelling evidence for the merits of a fourth approach: comprehensive risk factor management. Clinical outcome studies have confirmed the substantial merit of aspirin prophyllaxis and of intensive lipid-lowering therapy in secondary prevention. Prospective angiographic trials and evidence from studies of vascular biology have provided insight into mechanisms of benefit. As a consequence, lipid therapy and aspirin use have increased greatly among middle aged and older US citizens, especially those with CAD. The growth of comprehensive medical management now rivals that of invasive revascularization in secondary prevention.

journal_name

J Intern Med

journal_title

Journal of internal medicine

authors

Brown BG,Zhao XQ,Bardsley J,Albers JJ

doi

10.1046/j.1365-2796.1997.109132000.x

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

283-94

issue

4

eissn

0954-6820

issn

1365-2796

journal_volume

241

pub_type

杂志文章,评审

相关文献

JOURNAL OF INTERNAL MEDICINE文献大全
  • Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.

    abstract：:A normal brain function requires constant levels of cholesterol, and the need for constancy seems to be higher here than in any other organ. Nature has met this need by isolation of brain cholesterol by a highly efficient blood-brain barrier. As a low synthesis of cholesterol is present in the brain, a mechanism for c...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.2006.01725.x

    authors： Björkhem I

    更新日期：2006-12-01 00:00:00

  • Multiple risk intervention trial in high risk hypertensive men: comparison of ultrasound intima-media thickness and clinical outcome during 6 years of follow-up.

    abstract：OBJECTIVES:The objective was to analyse whether a favourable change in risk factors, caused by a comprehensive risk factor modification programme, affected intima-media thickness (IMT) in the common carotid artery, and whether any such change was associated with a change in cardiovascular events during a 6-year follow-...

    journal_title：Journal of internal medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2796.2001.00818.x

    authors： Agewall S,Fagerberg B,Berglund G,Schmidt C,Wendelhag I,Wikstrand J,Risk Factor Intervention Study Group, Sweden.

    更新日期：2001-04-01 00:00:00

  • The genetical history of humans and the great apes.

    abstract：:When and where did modern humans evolve? How did our ancestors spread over the world? Traditionally, answers to questions such as these have been sought in historical, archaeological, and fossil records. However, increasingly genetic data provide information about the evolution of our species. In this review, we focus...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.2002.00907.x

    authors： Kaessmann H,Pääbo S

    更新日期：2002-01-01 00:00:00

  • Effects of atorvastatin on serum lipids of patients with familial hypercholesterolaemia.

    abstract：OBJECTIVES:The effects of atorvastatin, a new synthetic HMG-CoA reductase inhibitor, were investigated in patients with familial hypercholesterolaemia (FH), with high LDLc levels whilst on standard treatment. DESIGN:Open treatment with 40 mg atorvastatin daily for 6 weeks, followed by another 6 weeks with 80 mg atorva...

    journal_title：Journal of internal medicine

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1365-2796.1998.00352.x

    authors： Hoogerbrugge N

    更新日期：1998-08-01 00:00:00

  • Relationships between vitamin D, parathyroid hormone and bone mineral density in inflammatory bowel disease.

    abstract：OBJECTIVES:To explore the relationships between vitamin D intake, serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (250HD) concentrations, and bone mineral density (BMD) in inflammatory bowel disease (IBD). SETTING:A university hospital clinic in Finland. SUBJECTS:One hundred and fifty randomly selected patien...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1996.420765000.x

    authors： Silvennoinen J

    更新日期：1996-02-01 00:00:00

  • Fatal adverse drug events: the paradox of drug treatment.

    abstract：OBJECTIVE:Study patient characteristics, morbidity patterns and drug regimens associated with fatal adverse drug events (FADEs) amongst medical department inpatients. DESIGN:An observational, descriptive study using aggregated medical records, autopsies and pre and postmortem drug analyses. SETTING:A department of in...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.2001.00892.x

    authors： Buajordet I,Ebbesen J,Erikssen J,Brørs O,Hilberg T

    更新日期：2001-10-01 00:00:00

  • The origins of the developmental origins theory.

    abstract：:Current orthodoxy states that coronary heart disease results from the unhealthy lifestyles of westernized adults together with a contribution from genetic inheritance. This does not provide a secure basis for prevention of the disease. Geographical studies gave the first clue that the disease originates during intra-u...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.2007.01809.x

    authors： Barker DJ

    更新日期：2007-05-01 00:00:00

  • Erythropoietic protoporphyria in Sweden: demographic, clinical, biochemical and genetic characteristics.

    abstract：OBJECTIVE:To investigate the demographic, clinical, biochemical and genotypic features of patients with erythropoietic protoporphyria (EPP) in a Swedish cohort. DESIGN:Cross-sectional questionnaire, biochemical and genetic study. SETTING:Sweden. SUBJECTS:Fifty-one Swedish individuals known in 2008 to have EPP confir...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2010.02236.x

    authors： Wahlin S,Floderus Y,Stål P,Harper P

    更新日期：2011-03-01 00:00:00

  • The occurrence of malignant disease in adult nephrotic syndrome.

    abstract：:The aim of the present study was to determine the incidence of malignant disease (MD) in adult patients with nephrotic syndrome (NS). Eighty-eight consecutive patients (38 females; 50 males; mean age 47 years; range 15-86) seen in a renal clinic in a 13-year period with NS were studied. Eight of the patients had or de...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1989.tb01380.x

    authors： Lund L,Jacobsen BA,Schmidt EB

    更新日期：1989-09-01 00:00:00

  • Assessment of thyroid and adrenal function in patients with familial amyloidotic polyneuropathy.

    abstract：:This study was performed to evaluate thyroid and adrenal function in patients with familial amyloidotic polyneuropathy. Twenty-four patients without any clinical overt endocrinological dysfunction were studied. None of the patients showed laboratory evidences of hypo- or hyperthyroidism. A short ACTH-stimulation test ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1989.tb00091.x

    authors： Olofsson BO,Grankvist K,Boman K,Forsberg K,Lafvas I,Lithner F

    更新日期：1989-05-01 00:00:00

  • Chlamydia pneumoniae IgA- and IgG antibodies in young survivors of myocardial infarction. A comparison of antibody detection by a microimmunofluorescence test and an enzyme immunoassay.

    abstract：OBJECTIVES:Chronic Chlamydia pneumoniae infection is considered as a cardiovascular risk factor and antibodies are commonly analysed by the subjective microimmunofluorescence (MIF) test. We wanted to investigate the C. pneumoniae IgA- and IgG seroprevalence in young survivors of myocardial infarction and matched contro...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.2002.00942.x

    authors： Halvorsen DS,Børvik T,Njølstad I,Gutteberg TJ,Vorland LH,Hansen JB

    更新日期：2002-02-01 00:00:00

  • Vaccines modulating lipoprotein autoimmunity as a possible future therapy for cardiovascular disease.

    abstract：:Current strategies for prevention of cardiovascular disease focus on risk factor intervention. Although these have been proven both safe and effective results from randomized clinical trials suggest that it is difficult to achieve relative risk reductions exceeding 40% with this approach. To further improve efficacy f...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.2009.02150.x

    authors： Nilsson J,Fredrikson GN,Björkbacka H,Chyu KY,Shah PK

    更新日期：2009-09-01 00:00:00

  • One year's experience of early defibrillation in Stockholm.

    abstract：:The effects of resuscitation on patients who died suddenly out of hospital were evaluated after the introduction of early defibrillation performed by ambulance personnel using semi-automatic defibrillators. Resuscitation attempts were initiated in 548 patients during the 1-year study period. Mean ambulance delay was 7...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1989.tb00085.x

    authors： Jakobsson J,Rehnqvist N,Nyquist O

    更新日期：1989-05-01 00:00:00

  • Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency.

    abstract：:Primary adrenal insufficiency (PAI), or Addison's disease, is a rare, potentially deadly, but treatable disease. Most cases of PAI are caused by autoimmune destruction of the adrenal cortex. Consequently, patients with PAI are at higher risk of developing other autoimmune diseases. The diagnosis of PAI is often delaye...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,实务指引,评审

    doi：10.1111/joim.12162

    authors： Husebye ES,Allolio B,Arlt W,Badenhoop K,Bensing S,Betterle C,Falorni A,Gan EH,Hulting AL,Kasperlik-Zaluska A,Kämpe O,Løvås K,Meyer G,Pearce SH

    更新日期：2014-02-01 00:00:00

  • Hepatitis C virus chronic infection as a common cause of mixed cryoglobulinaemia and autoimmune liver disease.

    abstract：OBJECTIVES:Mixed cryoglobulinaemia (MC) and autoimmune chronic hepatitis (AI-CH) are frequently associated with hepatitis C virus (HCV) chronic infection. Because HCV represents a possible common aetiological factor, the aim of the present study is to investigate the clinico-serological alterations of both MC and AI-CH...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1994.tb01116.x

    authors： Ferri C,Longombardo G,La Civita L,Greco F,Lombardini F,Cecchetti R,Cagianelli MA,Marchi S,Monti M,Zignego AL

    更新日期：1994-07-01 00:00:00

  • Neural stimulations regulate the infiltration of immune cells into the CNS.

    abstract：:The systemic regulation of immune reactions by the nervous system is well studied and depends on the release of hormones. Some regional regulations of immune reactions, on the other hand, depend on specific neural pathways. Better understanding of these regulations will expand therapeutic applications for neuroimmune ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/joim.12912

    authors： Kamimura D,Murakami M

    更新日期：2019-09-01 00:00:00

  • A new model for classification of disease manifestations in primary Sjögren's syndrome: evaluation in a retrospective long-term study.

    abstract：OBJECTIVES:The clinical features of 80 patients with primary Sjögren's syndrome (PSS) were revised in order to evaluate the descriptive and analytical facilities of a newly proposed model for classification of the exocrine and nonexocrine disease manifestations in PSS. DESIGN:Retrospective, long-term (median 7.5 years...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1996.418817000.x

    authors： Asmussen K,Andersen V,Bendixen G,Schiødt M,Oxholm P

    更新日期：1996-06-01 00:00:00

  • High rate of nonspecific anti-hepatitis C reactivity amongst homosexual men in comparison with that found in other sexually active groups and blood donors. Viral Hepatitis and AIDS Study Group.

    abstract：OBJECTIVES:To investigate the concordance of anti-hepatitis C virus (anti-HCV) reactivity by a second-generation enzyme immunoassay (EIA-2) and by a four-antigen recombinant immunoblot assay (4-RIBA) in homosexual men, in comparison with that found in other sexually active groups and blood donors. DESIGN:Prospective s...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1994.tb01122.x

    authors： Andreu J,Abad MA,Sanchez-Quijano A,Torronteras R,Luque F,Garcia de las Heras J,Soto B,Pineda JA,Leal M,Lissen E

    更新日期：1994-07-01 00:00:00

  • Influence of protease inhibitor therapy on lipoprotein metabolism.

    abstract：OBJECTIVES:Protease inhibitors are efficient drugs as part of highly active antiretroviral therapy. They have been shown to cause hyper- and dyslipoproteinemia. Since antiretroviral therapy is able to delay disease progression and possibly extend life expectancy in HIV-infected individuals, the precise nature of serum ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1999.00615.x

    authors： Berthold HK,Parhofer KG,Ritter MM,Addo M,Wasmuth JC,Schliefer K,Spengler U,Rockstroh JK

    更新日期：1999-12-01 00:00:00

  • Intraplaque haemorrhage at carotid artery surgery--a predictor of cardiovascular mortality.

    abstract：OBJECTIVE:To ascertain whether carotid intraplaque haemorrhage (IH) in patients undergoing carotid artery surgery is a predictor of increased cardiac mortality over a 5.5 year follow-up. DESIGN AND SUBJECTS:Carotid artery plaques were obtained at surgery from 47 consecutive patients (41 men, six women), median age 67 ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1995.tb00910.x

    authors： Falke P,Mätzsch T,Sternby NH,Bergqvist D,Stavenow L

    更新日期：1995-08-01 00:00:00

  • Hyperinsulinaemia, obesity, and syndrome X.

    abstract：OBJECTIVE:The major aim of this study was to compare various aspects of carbohydrate, insulin, and lipoprotein metabolism, serum uric acid concentration, and blood pressure in normal subjects stratified on the basis of both plasma insulin concentration and degree of obesity. The hypothesis to be tested was that hyperin...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1994.tb01031.x

    authors： Zavaroni I,Bonini L,Fantuzzi M,Dall'Aglio E,Passeri M,Reaven GM

    更新日期：1994-01-01 00:00:00

  • Impaired incretin effect is an early sign of glucose dysmetabolism in nondiabetic patients with psoriasis.

    abstract：BACKGROUND:Patients with psoriasis have an increased risk of type 2 diabetes. The gastrointestinal system plays a major role in normal glucose metabolism, and in healthy individuals, postprandial insulin secretion is largely mediated by the gut incretin hormones. This potentiation is termed the incretin effect and is r...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.12388

    authors： Gyldenløve M,Vilsbøll T,Zachariae C,Holst JJ,Knop FK,Skov L

    更新日期：2015-12-01 00:00:00

  • Lean mass and physical activity as predictors of bone mineral density in 16-20-year old women.

    abstract：OBJECTIVE:The aim of the study was to quantify the inter-relationship between bone mineral density and physical activity, muscle strength, and body mass composition in a group of healthy 16-20-year-old women. DESIGN:A cross-sectional study. SETTING:Reykjavik area. SUBJECTS:Two-hundred and fifty-four Icelandic Caucas...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1999.00486.x

    authors： Valdimarsson O,Kristinsson JO,Stefansson SO,Valdimarsson S,Sigurdsson G

    更新日期：1999-05-01 00:00:00

  • Pathogenesis and prevention of risk of cardiovascular events in patients with pneumococcal community-acquired pneumonia.

    abstract：:It is now well recognized that cardiovascular events (CVE) occur quite commonly, both in the acute phase and in the long-term, in patients with community-acquired pneumonia (CAP). CVE have been noted in up to 30% of patients hospitalized with all-cause CAP. One systematic review and meta-analysis of hospitalized patie...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/joim.12875

    authors： Feldman C,Normark S,Henriques-Normark B,Anderson R

    更新日期：2019-06-01 00:00:00

  • Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited.

    abstract：OBJECTIVES:Sunlight exposure of the skin is known to be the most important source of vitamin D. The aims of this study were: (i) to estimate vitamin D status amongst sunlight-deprived individuals (veiled Arab women, veiled ethnic Danish Moslem women and Danish controls); and (ii) through food intake analysis to estimat...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.2000.00595.x

    authors： Glerup H,Mikkelsen K,Poulsen L,Hass E,Overbeck S,Thomsen J,Charles P,Eriksen EF

    更新日期：2000-02-01 00:00:00

  • The effect of emergency department delay on outcome in critically ill medical patients: evaluation using hospital mortality and quality of life at 6 months.

    abstract：OBJECTIVE:To assess the impact of delay in emergency department (ED) on outcome of critically ill patients admitted to the medical intensive care unit (MICU). Outcome was defined as hospital mortality and as health-related quality of life (HRQoL) at 6 months after intensive care assessed by the 15D measure. The 15D is ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2006.01716.x

    authors： Saukkonen KA,Varpula M,Räsänen P,Roine RP,Voipio-Pulkki LM,Pettilä V

    更新日期：2006-12-01 00:00:00

  • Genes involved in animal models of obesity and anorexia.

    abstract：:Pathological deviations in bodyweight is a major increasing health problem in industrialized societies. It is currently unclear what genetic mechanisms are involved in the long-term control of human body-weight and to what extent these genes are involved in pathological deviations of bodyweight control such as anorexi...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.1999.00489.x

    authors： Schalling M,Johansen J,Nordfors L,Lönnqvist F

    更新日期：1999-06-01 00:00:00

  • Genotypes, phenotypes and treatment with immunomodulators in the rheumatic diseases.

    abstract：:The autoimmune rheumatological diseases rheumatoid arthritis (RA), spondyloarthritis (SpA) and systemic lupus erythematosus (SLE) are treated with conventional immunosuppressive agents and with modern biological immunomodulators. The latter group of medications have brought about a major change in our ability to contr...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/joim.12800

    authors： van Vollenhoven RF

    更新日期：2018-09-01 00:00:00

  • D-dimer levels and risk of recurrence following provoked venous thromboembolism: findings from the RIETE registry.

    abstract：BACKGROUND:Patients with venous thromboembolism (VTE) secondary to transient risk factors may develop VTE recurrences after discontinuing anticoagulation. Identifying at-risk patients could help to guide the duration of therapy. METHODS:We used the RIETE database to assess the prognostic value of d-dimer testing after...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.12969

    authors： Avnery O,Martin M,Bura-Riviere A,Barillari G,Mazzolai L,Mahé I,Marchena PJ,Verhamme P,Monreal M,Ellis MH,RIETE Investigators.

    更新日期：2020-01-01 00:00:00

  • Detection of blood Gb3 deposits as a new tool for diagnosis and therapy monitoring in patients with classic Fabry disease.

    abstract：BACKGROUND:The X-linked Fabry disease (FD) is a multiorgan disorder due to alpha-galactosidase A (α-GAL) deficiency with consequent lysosomal accumulation of globotriaosylceramide (Gb3). We established the immunocytochemical detection of Gb3 in blood cells of FD patients as a new method for FD diagnostics, follow-up an...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.12801

    authors： Üçeyler N,Böttger J,Henkel L,Langjahr M,Mayer C,Nordbeck P,Wanner C,Sommer C

    更新日期：2018-10-01 00:00:00