Glutamine and type 1 diabetes mellitus: is there a role in glycemic control?

Abstract:

PURPOSE OF REVIEW:Recent literature suggests dietary glutamine supplementation may lower blood glucose in patients with type 1 diabetes (T1D), who have no residual insulin secretion. The mechanisms and potential relevance to the care of T1D remain unclear. RECENT FINDINGS:Glutamine is involved in multiple pathways including gluconeogenesis, lipolysis, antioxidant defense, the production of nitric oxide, the secretion of peptides (e.g., glucagon-like peptide 1, GLP-1), or neuromediators (e.g., [Latin Small Letter Gamma]-aminobutyric acid), all processes that may impact insulin sensitivity and/or glucose homeostasis. The article reviews potential mechanisms and literature evidence suggesting a role in improving glucose tolerance in patients with illness associated with insulin resistance, as well as the preliminary evidence for the increased incidence of postexercise hypoglycemia in T1D after oral glutamine. SUMMARY:Further studies are warranted to determine whether the lowering effect of glutamine on blood glucose is sustained over time. If so, long-term randomized trials would be warranted to determine whether there is a role for glutamine as an adjunct dietary supplement to improve glucose control in patients with T1D.

authors

Darmaun D,Torres-Santiago L,Mauras N

doi

10.1097/MCO.0000000000000530

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

91-95

issue

1

eissn

1363-1950

issn

1473-6519

journal_volume

22

pub_type

杂志文章,评审
  • Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope?

    abstract:PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with a high prevalence of extrapulmonary manifestations and, frequently, cardiovascular comorbidity. Resveratrol is a food-derived compound with anti-inflammatory, antioxidant, metabolic and cardioprotective potential. Therefor...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000444

    authors: Beijers RJHCG,Gosker HR,Schols AMWJ

    更新日期:2018-03-01 00:00:00

  • Vitamin K: dietary intake and requirements in different clinical conditions.

    abstract:PURPOSE OF REVIEW:Vitamin K is an enzyme cofactor for the carboxylation of vitamin K-dependent proteins. Functions include coagulation and regulation of calcification. Different clinical conditions may alter vitamin K requirements by affecting vitamin K status and vitamin K-dependent proteins carboxylation that are rev...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000112

    authors: Harshman SG,Saltzman E,Booth SL

    更新日期:2014-11-01 00:00:00

  • Amino acid metabolism in liver disease.

    abstract::The impairment of transsulphuration during methionine degradation in hepatic failure can be counteracted by treatment with S-adenosylmethionine. Regarding the pathogenesis of hepatic encephalopathy, no convincing evidence exists for tryptophan, glutamine or glutamate being involved. Portal-systemic shunting-induced hy...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199901000-00009

    authors: Holm E,Sedlaczek O,Grips E

    更新日期:1999-01-01 00:00:00

  • Maximizing muscle protein anabolism: the role of protein quality.

    abstract:PURPOSE OF REVIEW:Muscle protein synthesis (MPS) and muscle protein breakdown are simultaneous ongoing processes. Here, we examine evidence for how protein quality can affect exercise-induced muscle protein anabolism or protein balance (MPS minus muscle protein breakdown). Evidence is highlighted showing differences in...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32831cef75

    authors: Tang JE,Phillips SM

    更新日期:2009-01-01 00:00:00

  • Interest of functional foods for low-income countries.

    abstract:PURPOSE OF REVIEW:To understand the interest of functional food in low-income countries by analyzing various necessary factors. RECENT FINDINGS:Being on a low income would appear to relate most often to an unbalanced diet, both qualitatively and quantitatively, which may be damaging to health in the long term. Most ch...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000111

    authors: Das A,Chakraborty R

    更新日期:2014-11-01 00:00:00

  • The gesture life of high mobility group box 1.

    abstract:PURPOSE OF REVIEW:Products of infection, ischemia, and injury stimulate the innate immune system to release proinflammatory cytokines, which act locally to activate specific cellular immune responses and initiate recovery. In pathological cases, however, cytokines are released systemically, resulting in progressive tis...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000068966.34812.b9

    authors: Friedman SG,Czura CJ,Tracey KJ

    更新日期:2003-05-01 00:00:00

  • Fructooligosaccharides and appetite.

    abstract:PURPOSE OF REVIEW:Dietary fiber may play a role in obesity prevention through reduction of body weight and control of appetite, however, not all fibers are created equally, and characteristics of fiber such as viscosity, fermentability and solubility may affect appetite differently. RECENT FINDINGS:Although early stud...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000502

    authors: Korczak R,Slavin JL

    更新日期:2018-09-01 00:00:00

  • Dietary supplement intake among the elderly: hazards and benefits.

    abstract:PURPOSE OF REVIEW:A large percentage of older adults do not receive recommended amounts of many nutrients from food alone. Accordingly, the routine use of dietary supplements has become common among older persons. Although supplement use provides potential benefits by increasing nutrient intakes, there are potential dr...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000512

    authors: Walrand S

    更新日期:2018-11-01 00:00:00

  • Vitamin K status in the elderly.

    abstract:PURPOSE OF REVIEW:Poor vitamin K nutrition has recently been linked to several chronic diseases associated with abnormal calcification, which affect many elderly. To understand the impact of vitamin K nutrition on healthy aging it is necessary to assess both the determinants and the adequacy of vitamin K nutritional st...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e328011ab5f

    authors: Booth SL

    更新日期:2007-01-01 00:00:00

  • Bedside ultrasound measurement of skeletal muscle.

    abstract:PURPOSE OF REVIEW:Skeletal muscle and lean body mass may be vital to prognosis and functional recovery in chronic and acute illness, particularly in conditions in which muscle atrophy is prevalent. Ultrasound provides a precise and expedient method to measure muscle mass and changes in skeletal muscle at the bedside. ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000088

    authors: Mourtzakis M,Wischmeyer P

    更新日期:2014-09-01 00:00:00

  • Are prospective cohort studies an appropriate tool to answer clinical nutrition questions?

    abstract:PURPOSE OF REVIEW:Randomized controlled trials can be difficult to conduct in critically ill patients and may not always be the most appropriate type of study. Cohort studies can provide valuable information in large complete populations of patients without strict exclusion criteria and without the need for informed co...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32835d803e

    authors: Vincent JL,Preiser JC

    更新日期:2013-03-01 00:00:00

  • Genetic and metabolic determinants of human epigenetic variation.

    abstract:PURPOSE OF REVIEW:Epigenetics has emerged in recent years as one of the most important biological mechanisms linking exposures across the life course to long-term health. This article reviews recent developments in our understanding of the metabolic and genetic determinants of epigenetic variation in human populations....

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000194

    authors: Haggarty P

    更新日期:2015-07-01 00:00:00

  • Nutrient interaction for optimal protein anabolism in resistance exercise.

    abstract:PURPOSE OF REVIEW:The rapid muscle loss that accompanies varying diseased states (cachexia) is due to an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown In the current review, we will discuss and summarize recent evidence in order to provide practical recommendations on exercise and nutrie...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283516850

    authors: Breen L,Phillips SM

    更新日期:2012-05-01 00:00:00

  • The Geriatric Nutritional Risk Index.

    abstract:PURPOSE OF REVIEW:A new nutrition-related risk assessment tool, the Geriatric Nutritional Risk Index (GNRI), has been recently proposed. The aim of this review is to summarize current evidences on the use of this tool with particular focus on the rationales of its application in elderly healthcare. RECENT FINDINGS:Str...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283186f59

    authors: Cereda E,Pedrolli C

    更新日期:2009-01-01 00:00:00

  • Some interactions between gastrointestinal function and fluid and electrolyte homeostasis.

    abstract:PURPOSE OF REVIEW:The gastrointestinal tract plays an important role in the maintenance of fluid and electrolyte balance, and its diseases cause disturbances in that balance. Conversely, fluid and electrolyte disorders may disturb gastrointestinal function. The purpose of this review is to highlight some recent literat...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200503000-00015

    authors: Macafee DA,Allison SP,Lobo DN

    更新日期:2005-03-01 00:00:00

  • Protein and amino acids in nonalcoholic fatty liver disease.

    abstract:PURPOSE OF REVIEW:In this review, the latest evidence on the influence of dietary protein and plasma amino acids in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is discussed. RECENT FINDINGS:Increasing protein consumption during weight loss and maintenance may help reduce liver fat content. Conversely,...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000706

    authors: Tricò D,Biancalana E,Solini A

    更新日期:2021-01-01 00:00:00

  • Severe acute malnutrition.

    abstract:PURPOSE OF REVIEW:The mortality and morbidity associated with severe acute malnutrition (SAM) remain high. A summary of recent studies that are of interest to clinicians treating children with SAM is provided. RECENT FINDINGS:Three important themes emerged in 2015: the use of anthropometry in the diagnosis of SAM and ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000269

    authors: Nel ED

    更新日期:2016-05-01 00:00:00

  • The role of the peroxisome proliferator-activated receptor alpha pathway in pathological remodeling of the diabetic heart.

    abstract:PURPOSE OF REVIEW:Cardiovascular disease is exceptionally prevalent in patients with diabetes mellitus, which is an emerging pandemic. Unfortunately, the pathogenesis of diabetic myocardial disease is still poorly understood. RECENT FINDINGS:Evidence has emerged that perturbed cardiac energy metabolism (excessive depe...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000134371.70815.32

    authors: Finck BN

    更新日期:2004-07-01 00:00:00

  • Protein and physical activity in older persons.

    abstract:PURPOSE OF REVIEW:The aim of this study was to highlight recent evidence on protein requirement and physical activity recommendations in older adults and their interrelationship. RECENT FINDINGS:Higher protein intake in older adults is beneficial for better physical function, reduced fracture risk, healthy ageing and ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000685

    authors: Yeung SSY,Chan RSM,Woo J

    更新日期:2021-01-01 00:00:00

  • Parenteral nutrition in critical illness: total, supplemental or never?

    abstract:PURPOSE OF REVIEW:The current review summarizes recent evolutions in knowledge and discusses the concept of whom and when parenteral nutrition should be considered in critically ill patients as a total form of nutrition, in a supplemental form, or never. RECENT FINDINGS:Recent developments in our understanding of the ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000719

    authors: Ridley EJ

    更新日期:2020-12-10 00:00:00

  • Assessing vitamin D status.

    abstract:PURPOSE OF REVIEW:To characterize methods evaluating and to summarize studies linking various serum 25-hydroxyvitamin D [25(OH)D] concentrations with health status. RECENT FINDINGS:Elucidation of the cell-biologic mechanism of vitamin D action, and numerous clinical trials and observational studies relating vitamin D ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e328348ed85

    authors: Heaney RP

    更新日期:2011-09-01 00:00:00

  • Improving dietary patterns in patients with nonalcoholic fatty liver disease.

    abstract:PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) is the liver epidemic of our time. Diet strongly influences its development and should be a component of any treatment plan. It is crucial to standardize diet recommendations in an evidence-based manner. RECENT FINDINGS:Calorie restriction per se seems benefic...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283566614

    authors: Carvalhana S,Machado MV,Cortez-Pinto H

    更新日期:2012-09-01 00:00:00

  • The role of probiotics in gastrointestinal surgery.

    abstract:PURPOSE OF REVIEW:Postoperative complications in gastrointestinal elective surgery have been described as low. In certain circumstances, however, such as those including high-risk patients, the incidence is higher. In such situations, bacteremia and infectious complications may be caused by translocation of either gast...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000241674.55417.c9

    authors: Correia MI,Nicoli JR

    更新日期:2006-09-01 00:00:00

  • Mechanisms regulating brain docosahexaenoic acid uptake: what is the recent evidence?

    abstract:PURPOSE OF REVIEW:To summarize recent advances pertaining to the mechanisms regulating brain docosahexaenoic acid (DHA) uptake. DHA is an omega-3 polyunsaturated fatty acid highly enriched in neuronal membranes and it is implicated in several important neurological processes. However, DHA synthesis is extremely limited...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000440

    authors: Chouinard-Watkins R,Lacombe RJS,Bazinet RP

    更新日期:2018-03-01 00:00:00

  • Protein anabolic resistance in cancer: does it really exist?

    abstract:PURPOSE OF REVIEW:Preventing unintentional weight and muscle loss is of crucial importance to maintain the condition and well-being of patients with cancer, improve treatment response and tolerance, and prolong survival. Anabolic resistance might explain why some cancer patients do not respond to nutritional interventi...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000236

    authors: Engelen MP,van der Meij BS,Deutz NE

    更新日期:2016-01-01 00:00:00

  • Omega-3 fatty acids and human skeletal muscle.

    abstract:PURPOSE OF REVIEW:To examine recent findings related to the influence of omega-3 (ω-3) fatty acid supplementation on skeletal muscle anabolism with a particular focus on situations of skeletal muscle disuse. RECENT FINDINGS:Skeletal muscle disuse results in a reduction in fed and fasted rates of skeletal muscle protei...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000723

    authors: Ferguson EJ,Seigel JW,McGlory C

    更新日期:2020-12-15 00:00:00

  • Tissue-selective expression of enzymes of arginine synthesis.

    abstract::Arginine is a non-essential amino acid in mammals as judged from nitrogen balance study. Citrulline is synthesized from glutamate in the small intestine, whilst kidneys and some other tissues convert citrulline to arginine. Ornithine transcarbamylase and carbamylphosphate synthetase are expressed in liver and small in...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199807000-00004

    authors: Wakabayashi Y

    更新日期:1998-07-01 00:00:00

  • Protein metabolic roles in treatment of obesity.

    abstract:PURPOSE OF REVIEW:To understand the potential benefits of increased dietary protein during weight loss and the importance of distribution of high-quality protein at each meal. RECENT FINDINGS:Popular weight loss diets emphasize use of protein as a substitute for carbohydrates or fat to reduce insulin and minimize hung...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32833a7737

    authors: Devkota S,Layman DK

    更新日期:2010-07-01 00:00:00

  • Fast digestive proteins and sarcopenia of aging.

    abstract:PURPOSE OF REVIEW:The speed of dietary protein digestion influences postprandial amino acid availability which is crucial for improving altered anabolic response of skeletal muscle one feature of sarcopenia during aging. RECENT FINDINGS:By analogy with carbohydrate and in reference to their absorption rate, dietary pr...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000427

    authors: Boirie Y,Guillet C

    更新日期:2018-01-01 00:00:00

  • Nutrient regulation of intestinal gene expression.

    abstract::This review examines recent advances in the dietary modulation of gene expression in the gastrointestinal tract. We have chosen to concentrate on individual genes and examine what is known about their regulation, attempting to link different studies together. ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199907000-00009

    authors: Kelly EJ,Sanderson IR

    更新日期:1999-07-01 00:00:00