Protein metabolic roles in treatment of obesity.

Abstract:

PURPOSE OF REVIEW:To understand the potential benefits of increased dietary protein during weight loss and the importance of distribution of high-quality protein at each meal. RECENT FINDINGS:Popular weight loss diets emphasize use of protein as a substitute for carbohydrates or fat to reduce insulin and minimize hunger and food cravings. These diets produce short-term weight loss, but long-term benefits remain obscured by failure to differentiate between outcomes of subject compliance and diet effectiveness. New molecular mechanisms have defined the benefits of protein as a meal threshold for the branched-chain amino acid leucine, which has been characterized as a unique signal regulator of muscle protein synthesis. Leucine consumed at 2.5 g triggers a postmeal anabolic response that protects metabolic active tissues during weight loss and increases loss of body fat. SUMMARY:Balanced daily distribution of protein with increased intake at breakfast and lunch protects metabolically active tissues including skeletal muscle during weight loss.

authors

Devkota S,Layman DK

doi

10.1097/MCO.0b013e32833a7737

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

403-7

issue

4

eissn

1363-1950

issn

1473-6519

journal_volume

13

pub_type

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