Abstract:
PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steato hepatitis have an increasing prevalence among liver diseases. Overweight and obesity are frequently associated conditions in patients with fatty liver. Skeletal muscle mass depletion may also coexist with chronic liver disease even in obese patients. This review will focus on the relationship between sarcopenic obesity and fatty liver. RECENT FINDINGS:Obesity and sarcopenia are frequently encountered in patients with NAFLD. Adipose tissue is able to release molecules (adipokines) that regulate lipid metabolism, interact with insulin sensitivity and may contribute to induce fibrogenesis in the liver. Skeletal muscle tissue is able to secrete myokines regulating muscle metabolism and insulin sensitivity. Myokines perturbation has been reported to influence adipose tissue mass and fat deposition in the liver. Sarcopenia has been reported as independent risk factor for the development of NAFLD, and for a more severe liver fibrosis in patients with NAFLD. SUMMARY:The interaction between skeletal muscle, adipose tissue and the liver may play a role in the development of NAFLD. Sarcopenia and sarcopenic obesity are risk factors for the development of fatty liver and associated with more severe liver fibrosis. Management is not standardized, but dietary counseling and physical training have been proposed as promising strategies. Bariatric surgery may be considered in patients with severe 'resistant' obesity.
journal_name
Curr Opin Clin Nutr Metab Carejournal_title
Current opinion in clinical nutrition and metabolic careauthors
Merli M,Lattanzi B,Aprile Fdoi
10.1097/MCO.0000000000000558subject
Has Abstractpub_date
2019-05-01 00:00:00pages
185-190issue
3eissn
1363-1950issn
1473-6519journal_volume
22pub_type
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200403000-00003
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journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
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doi:10.1097/MCO.0b013e32835e3643
更新日期:2013-05-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
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更新日期:2014-09-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章
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journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
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更新日期:2011-01-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200503000-00015
更新日期:2005-03-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000236
更新日期:2016-01-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章
doi:10.1097/MCO.0000000000000305
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Products of infection, ischemia, and injury stimulate the innate immune system to release proinflammatory cytokines, which act locally to activate specific cellular immune responses and initiate recovery. In pathological cases, however, cytokines are released systemically, resulting in progressive tis...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000068966.34812.b9
更新日期:2003-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The intake of water and electrolytes is inseparable from the ingestion of nutrients by normal or artificial means. Recent reports have agreed in criticizing the poor standards of practice and of training in the management of fluid and electrolyte balance, resulting in a large amount of avoidable morbi...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200401000-00006
更新日期:2004-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe the recent advances in our understanding of fatty acids and lipids in paediatric nonalcoholic fatty liver disease (NAFLD) and their future implications. RECENT FINDINGS:Data have been accumulated to suggest that ceramides are the main drivers of hepatic insulin resistance in NAFLD, and in...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000346
更新日期:2017-03-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000170756.71114.78
更新日期:2005-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To characterize methods evaluating and to summarize studies linking various serum 25-hydroxyvitamin D [25(OH)D] concentrations with health status. RECENT FINDINGS:Elucidation of the cell-biologic mechanism of vitamin D action, and numerous clinical trials and observational studies relating vitamin D ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328348ed85
更新日期:2011-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss transcriptional mechanisms regulating hepatic lipid metabolism. RECENT FINDINGS:Humans who are obese or have diabetes (NIDDM) or metabolic syndrome (MetS) have low blood and tissue levels of C20-22 polyunsaturated fatty acids (PUFAs). Although the impact of low C20-22 PUFAs on disease prog...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328342991c
更新日期:2011-03-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000052
更新日期:2014-05-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000124
更新日期:2015-01-01 00:00:00
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doi:10.1097/MCO.0b013e32832c97c3
更新日期:2009-07-01 00:00:00
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更新日期:2010-05-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
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更新日期:2019-01-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:2008-05-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:2004-11-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:2008-07-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:2006-07-01 00:00:00