Polyunsaturated fatty acids, membrane function and metabolic diseases such as diabetes and obesity.

abstract：PURPOSE OF REVIEW:The obesity paradox is a highly controversial concept that may be attributed to methodological limitations related to its identification. One of the primary concerns is the use of BMI to define obesity. This index does not differentiate lean versus adipose tissue compartments (i.e. body composition) c...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Prado CM,Gonzalez MC,Heymsfield SB

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steato hepatitis have an increasing prevalence among liver diseases. Overweight and obesity are frequently associated conditions in patients with fatty liver. Skeletal muscle mass depletion may also coexist with chronic liver disease even in ob...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Merli M,Lattanzi B,Aprile F

更新日期：2019-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Muscular mitochondrial dysfunction, leading to the accumulation of fat in skeletal muscle, has been proposed to be involved in the development of type 2 diabetes mellitus. Here, we review human studies that investigated various aspects of mitochondrial function in relation to muscular insulin sensitiv...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Schrauwen-Hinderling VB,Roden M,Kooi ME,Hesselink MK,Schrauwen P

更新日期：2007-11-01 00:00:00

abstract：:Lipophilic molecules can passively diffuse across cell membranes, a process that is driven by the concentration gradient, by availability of acceptors to facilitate desorption from the bilayer, and by cellular metabolism. However, evidence has accumulated that supports the existence of specialized, protein-facilitated...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Abumrad NA,Sfeir Z,Connelly MA,Coburn C

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The data indicating that alcohol is an important factor increasing the risk to develop gastrointestinal cancer are consolidating. The purpose of this review is to summarize current evidence. RECENT FINDINGS:Acetaldehyde is the first metabolite of ethanol metabolism and has direct carcinogenic and mut...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Haas SL,Ye W,Löhr JM

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Trehalose is a disaccharide with manifold industrial, commercial and biomedical uses. In the decade following its initial definition as an autophagy-inducing agent, significant advances have been realized in regard to the applicable clinical and preclinical contexts in which trehalose can be deployed....

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Zhang Y,DeBosch BJ

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Sarcopenia is a progressive generalized decline in skeletal muscle mass, strength, and function. This condition is highly prevalent in critically ill patients and is associated with poor outcomes in the ICU. In this review, we describe the use, evidence, and limitations of the most common validated im...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Lopez-Ruiz A,Kashani K

更新日期：2020-09-01 00:00:00

abstract：:Laboratory methods for the measurement of micronutrients are usually based upon determinations in the peripheral blood. Most are relatively insensitive, but can screen for impending acute deficiency or toxicity. The metabolic responses to disease, injury and infection may alter the laboratory findings independently of...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Fell GS,Talwar D

更新日期：1998-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The diagnosis of aspiration and its origin in patients on enteral tube feeding is challenging to the physician and provides an important means to prevent pneumonia. This review examines the most recent studies and developments in the field with an approach to the technical aspects of diagnostic method...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Gomes GF,Campos AC,Pisani JC,Macedo ED,Vieira MC

更新日期：2004-05-01 00:00:00

abstract：:The most common methods for measuring the incorporation of tracer amino acids into tissue protein are the constant tracer infusion and the flooding dose. The flooding dose is an attractive method for measuring tissue protein synthesis because of its convenience and precision. A primary assumption of the method, that t...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Davis TA,Reeds PJ

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the present review is to provide insights into the future therapeutic approaches to cancer-related muscle wasting that flow from the progressive knowledge of mechanisms regulating muscle mass in health and disease. RECENT FINDINGS:Cancer cachexia is a severely debilitating and life-threate...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Muscaritoli M,Bossola M,Bellantone R,Rossi Fanelli F

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Dyspepsia is a common disorder that presents as persistent or recurrent abdominal pain or discomfort in the upper abdomen and originates from organic or functional causes. Heterogeneous disorders, physiopathological, psychosomatic, sociocultural, demographic and genetic components have a great impact ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： de Baptista GA

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with a high prevalence of extrapulmonary manifestations and, frequently, cardiovascular comorbidity. Resveratrol is a food-derived compound with anti-inflammatory, antioxidant, metabolic and cardioprotective potential. Therefor...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Beijers RJHCG,Gosker HR,Schols AMWJ

更新日期：2018-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The prevalence of nonalcoholic fatty liver disease is increasing worldwide and there is strong evidence that dietary factors play a role in its pathogenesis. The present review aims to provide a better understanding of how carbohydrates and other macronutrients may affect the disease. RECENT FINDINGS...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Lê KA,Bortolotti M

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the literature concerning the relationship between meal patterns and childhood obesity. Literature searches of MEDLINE and the Cochrane Library were performed in October 2009 for studies published in the last 18-24 months. RECENT FINDINGS:Available data indicate that not only meal compos...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Patro B,Szajewska H

更新日期：2010-05-01 00:00:00

abstract：:New results on the physiological properties of conjugated linoleic acid have been published by several working groups, especially showing the effects of single conjugated linoleic acid isomers on carcinogenesis and body composition. Recently, other studies have shown that conjugated linoleic acid has an influence on d...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Sébédio JL,Gnaedig S,Chardigny JM

更新日期：1999-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Insulin resistance is an important risk factor for metabolic diseases such as type 2 diabetes, cardiovascular disease and certain cancers. A common characteristic of strategies that improve insulin sensitivity involves the activation of the energy sensing enzyme of the cell, AMP-activated protein kina...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Smith BK,Steinberg GR

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Here, we discuss recent work focused on the role of activating transcription factor 4 (ATF4) in skeletal muscle atrophy. RECENT FINDINGS:Muscle atrophy involves and requires widespread changes in skeletal muscle gene expression; however, the transcriptional regulatory proteins responsible for those c...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Adams CM,Ebert SM,Dyle MC

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The mortality and morbidity associated with severe acute malnutrition (SAM) remain high. A summary of recent studies that are of interest to clinicians treating children with SAM is provided. RECENT FINDINGS:Three important themes emerged in 2015: the use of anthropometry in the diagnosis of SAM and ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Nel ED

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Folic acid is now considered an important functional food component: it lowers potentially toxic homocysteine, prevents birth defects and modulates the risk of several cancers. The complexity of interactions involved, however, means we still have much to learn about the role of folate and homocysteine...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Lucock MD

更新日期：2006-11-01 00:00:00

abstract：:Arginine is a non-essential amino acid in mammals as judged from nitrogen balance study. Citrulline is synthesized from glutamate in the small intestine, whilst kidneys and some other tissues convert citrulline to arginine. Ornithine transcarbamylase and carbamylphosphate synthetase are expressed in liver and small in...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Wakabayashi Y

更新日期：1998-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to provide a concise overview of the polyphenol curcumin for improving arterial health, specifically endothelial function and arterial stiffness, to reduce cardiovascular disease (CVD) risk and to highlight potential mechanisms of action by which curcumin may improve arte...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Fleenor BS,Carlini NA,Campbell MS

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, the latest evidence on the influence of dietary protein and plasma amino acids in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is discussed. RECENT FINDINGS:Increasing protein consumption during weight loss and maintenance may help reduce liver fat content. Conversely,...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Tricò D,Biancalana E,Solini A

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Preventing unintentional weight and muscle loss is of crucial importance to maintain the condition and well-being of patients with cancer, improve treatment response and tolerance, and prolong survival. Anabolic resistance might explain why some cancer patients do not respond to nutritional interventi...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Engelen MP,van der Meij BS,Deutz NE

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an objective and comprehensive review of the recent literature addressing the effects of sex on protein metabolism. We also evaluate whether these differences can be attributed to physiology or methodology. Because of the developmental changes in hormonal milieu and body composition that oc...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Markofski MM,Volpi E

更新日期：2011-01-01 00:00:00

abstract：:Food products have variously been reported as causing, perpetuating or treating irritable bowel syndrome. The evidence for this is reviewed with regard to recent studies investigating symptom reporting, mono- and disaccharide malabsorption and probiotics. The development of objective measures remains an urgent priorit...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Dunlop SP,Spiller RC

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Until relatively recently, the only significant source of lactoferrin in the diet was human lactoferrin, provided in breast milk. Today, however, bovine lactoferrin, isolated by dairy technology, as well as recombinant human lactoferrin are commercially available and can be added to foods and clinical...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Lönnerdal B

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The rapid muscle loss that accompanies varying diseased states (cachexia) is due to an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown In the current review, we will discuss and summarize recent evidence in order to provide practical recommendations on exercise and nutrie...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Breen L,Phillips SM

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Lipid sources for enteral nutrition continue to be an exciting area of investigation. It is timely to review recent developments which have largely contributed to thrust enteral feeding into a new era. RECENT FINDINGS:Although much more research needs to be done, there is a better understanding of th...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Roy CC,Bouthillier L,Seidman E,Levy E

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Malnutrition and polypharmacy increase with age and polymorbidity and their relationship is based on a number of mechanisms. The occurrence of malnutrition in both in-patients and out-patients and its dependence on polymorbidity and age are well known, but the interrelation of polypharmacy and malnutr...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Zadak Z,Hyspler R,Ticha A,Vlcek J

更新日期：2013-01-01 00:00:00