Tissue-selective expression of enzymes of arginine synthesis.

Abstract:

:Arginine is a non-essential amino acid in mammals as judged from nitrogen balance study. Citrulline is synthesized from glutamate in the small intestine, whilst kidneys and some other tissues convert citrulline to arginine. Ornithine transcarbamylase and carbamylphosphate synthetase are expressed in liver and small intestine. Tissue-selective expression depends on the regulatory elements in the promoter, or far 5', region of these genes to which tissue-selective transcription factors bind and activate transcription. Argininosuccinate synthetase and argininosuccinate lyase do not appear to have such elements, therefore their expression is more or less ubiquitous. The selective expression of pyrroline-5-carboxylate synthase activity in the intestine remains to be clarified.

authors

Wakabayashi Y

doi

10.1097/00075197-199807000-00004

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

335-9

issue

4

eissn

1363-1950

issn

1473-6519

journal_volume

1

pub_type

杂志文章,评审
  • Diet of lactating women and allergic reactions in their infants.

    abstract:PURPOSE OF REVIEW:To evaluate whether the diet of lactating women modulates the development of allergic disease in their children. RECENT FINDINGS:Although maternal avoidance of common food protein allergens was previously recommended for lactating women with infants predisposed to allergic disease, recent expert revi...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000222113.46042.50

    authors: Palmer DJ,Makrides M

    更新日期:2006-05-01 00:00:00

  • Nutritional assessment in the hospitalized patient.

    abstract:PURPOSE OF REVIEW:Malnutrition is highly prevalent in hospitalized patients. Despite this, it is not routinely assessed in most hospitals worldwide. One of the reasons that might explain this fact is that there is no gold-standard nutritional assessment tool, and much has been written advocating this or that technique....

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200309000-00006

    authors: Waitzberg DL,Correia MI

    更新日期:2003-09-01 00:00:00

  • Leptin and energy expenditure.

    abstract:PURPOSE OF REVIEW:A fundamental advance in our understanding of endocrine control of energy balance and body weight came with the discovery of the adipocyte-derived hormone leptin. The leptin pathway appeared to be the long-sought peripheral signal pathway from the adipose tissue to the brain involved in the regulation...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200411000-00007

    authors: Hukshorn CJ,Saris WH

    更新日期:2004-11-01 00:00:00

  • Plant-derived phenolic antioxidants.

    abstract::Antioxidant nutrients are important for limiting damaging oxidative reactions in cells, which may predispose to the development of major clinical conditions such as heart disease and cancer. There is great interest in the possibility that the antioxidant potential of plant-derived phenolic compounds, such as flavonoid...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200011000-00006

    authors: Duthie G,Crozier A

    更新日期:2000-11-01 00:00:00

  • Sarcopenic obesity in fatty liver.

    abstract:PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steato hepatitis have an increasing prevalence among liver diseases. Overweight and obesity are frequently associated conditions in patients with fatty liver. Skeletal muscle mass depletion may also coexist with chronic liver disease even in ob...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000558

    authors: Merli M,Lattanzi B,Aprile F

    更新日期:2019-05-01 00:00:00

  • Anabolic hormones in critically ill patients.

    abstract::Critical illness and severe injury induce a number of neuroendocrine changes that initially enhance survival. However, for skeletal muscle, the hormonal environment is such that accelerated catabolism predominates. The prevailing hypercortisolemia is exacerbated by a resistance to or decreased production of anabolic h...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199903000-00014

    authors: Ferrando AA

    更新日期:1999-03-01 00:00:00

  • Genetic and metabolic determinants of human epigenetic variation.

    abstract:PURPOSE OF REVIEW:Epigenetics has emerged in recent years as one of the most important biological mechanisms linking exposures across the life course to long-term health. This article reviews recent developments in our understanding of the metabolic and genetic determinants of epigenetic variation in human populations....

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000194

    authors: Haggarty P

    更新日期:2015-07-01 00:00:00

  • Interest of functional foods for low-income countries.

    abstract:PURPOSE OF REVIEW:To understand the interest of functional food in low-income countries by analyzing various necessary factors. RECENT FINDINGS:Being on a low income would appear to relate most often to an unbalanced diet, both qualitatively and quantitatively, which may be damaging to health in the long term. Most ch...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000111

    authors: Das A,Chakraborty R

    更新日期:2014-11-01 00:00:00

  • Potential intracellular targets for anabolic/anti-catabolic therapies.

    abstract::The intracellular signalling pathways controlling muscle protein synthesis and proteolysis are potential targets for anabolic/anti-catabolic therapy. In this review, we consider both the potentiation of the effect of anabolic hormones and suppression of the catabolic action of cytokines. Potential candidates, in parti...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199905000-00004

    authors: Palmer RM,Thompson MG

    更新日期:1999-05-01 00:00:00

  • Fatty acids and endothelial cell function: regulation of adhesion molecule and redox enzyme expression.

    abstract::Different types of dietary fatty acids have distinct, and sometimes opposing, effects on endothelial cell function. Long-chain n-3 polyunsaturated fatty acids from fish oil (eicosapentaenoic-acid-20:5n-3 and docosahexaenoic-acid-22:6n-3) attenuate cytokine-induced adhesion molecule expression (mRNA and protein) while ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199903000-00003

    authors: Wahle KW,Rotondo D

    更新日期:1999-03-01 00:00:00

  • Body composition phenotypes and obesity paradox.

    abstract:PURPOSE OF REVIEW:The obesity paradox is a highly controversial concept that may be attributed to methodological limitations related to its identification. One of the primary concerns is the use of BMI to define obesity. This index does not differentiate lean versus adipose tissue compartments (i.e. body composition) c...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000216

    authors: Prado CM,Gonzalez MC,Heymsfield SB

    更新日期:2015-11-01 00:00:00

  • Infection control issues of enteral feeding systems.

    abstract::Enteral feeding systems provide a mechanism for nutritional support for patients who may be unable to tolerate oral dietary sustenance. This review takes into account recent infection control issues relating to enteral feeding systems. The review is organized into the following areas of emphasis: infections associated...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200009000-00006

    authors: Marion ND,Rupp ME

    更新日期:2000-09-01 00:00:00

  • Meal patterns and childhood obesity.

    abstract:PURPOSE OF REVIEW:To summarize the literature concerning the relationship between meal patterns and childhood obesity. Literature searches of MEDLINE and the Cochrane Library were performed in October 2009 for studies published in the last 18-24 months. RECENT FINDINGS:Available data indicate that not only meal compos...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32833681a2

    authors: Patro B,Szajewska H

    更新日期:2010-05-01 00:00:00

  • Clogbusting: time for a concerted approach to catheter occlusions?

    abstract:PURPOSE OF REVIEW:Occlusions of central venous catheters in service are frequent, but the random nature of the problem has resulted in a piecemeal approach to solving it. The purpose of this review is to examine what is known from past and recent publications and to recommend strategies for future investigations. RECE...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000165006.39449.1f

    authors: Hardy G,Ball P

    更新日期:2005-05-01 00:00:00

  • Amino acid metabolism in liver disease.

    abstract::The impairment of transsulphuration during methionine degradation in hepatic failure can be counteracted by treatment with S-adenosylmethionine. Regarding the pathogenesis of hepatic encephalopathy, no convincing evidence exists for tryptophan, glutamine or glutamate being involved. Portal-systemic shunting-induced hy...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199901000-00009

    authors: Holm E,Sedlaczek O,Grips E

    更新日期:1999-01-01 00:00:00

  • Non-nutritive sweeteners, energy balance, and glucose homeostasis.

    abstract:PURPOSE OF REVIEW:To review the recent work on potential mechanisms underlying a paradoxical positive association between the consumption of non-nutritive sweeteners (NNS) and weight gain. RECENT FINDINGS:Several potential mechanisms, not mutually exclusive, are hypothesized. First, by dissociating sweetness from calo...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283468e7e

    authors: Pepino MY,Bourne C

    更新日期:2011-07-01 00:00:00

  • Vitamin E and nonalcoholic fatty liver disease.

    abstract:PURPOSE OF REVIEW:Oxidative stress plays a central role in the transition from simple steatosis to nonalcoholic steatohepatitis (NASH). An effective therapeutic strategy is to target reduction in oxidative stress in NASH patients. The aim of this review is to discuss the role of oxidative stress in NASH and biological ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e328357f747

    authors: Pacana T,Sanyal AJ

    更新日期:2012-11-01 00:00:00

  • Colon cancer therapy: new perspectives of nutritional manipulations using polyunsaturated fatty acids.

    abstract:PURPOSE OF REVIEW:Recent advances in the development of new therapeutic strategies combining conventional adjuvant radio/chemotherapy with nutritional manipulations with n-3 polyunsaturated fatty acids (PUFAs) are presented. RECENT FINDINGS:Studies in cell culture and tumour-bearing animals have reported the ability o...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3281e2c9d4

    authors: Dupertuis YM,Meguid MM,Pichard C

    更新日期:2007-07-01 00:00:00

  • Fructose malabsorption syndrome.

    abstract:PURPOSE OF REVIEW:Fructose malabsorption is associated with gastrointestinal symptoms. This review examines new findings on the physiology, assessment and therapy of fructose malabsorption in functional gastrointestinal disorders. RECENT FINDINGS:Additional GLUT transport mechanisms that regulate fructose absorption m...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e328361c556

    authors: Putkonen L,Yao CK,Gibson PR

    更新日期:2013-07-01 00:00:00

  • Inflammatory status and insulin resistance.

    abstract:PURPOSE OF REVIEW:The inflammatory response is essential in the response to pathogens. TNF-alpha, IL-1 and IL-6 are key mediators of the response. They initiate metabolic changes to provide nutrients for the immune system, from host tissues. These changes include hyperlipidemia and increased gluconeogenesis. Insulin re...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200209000-00015

    authors: Grimble RF

    更新日期:2002-09-01 00:00:00

  • Maximizing muscle protein anabolism: the role of protein quality.

    abstract:PURPOSE OF REVIEW:Muscle protein synthesis (MPS) and muscle protein breakdown are simultaneous ongoing processes. Here, we examine evidence for how protein quality can affect exercise-induced muscle protein anabolism or protein balance (MPS minus muscle protein breakdown). Evidence is highlighted showing differences in...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32831cef75

    authors: Tang JE,Phillips SM

    更新日期:2009-01-01 00:00:00

  • Nutrient regulation of intestinal gene expression.

    abstract::This review examines recent advances in the dietary modulation of gene expression in the gastrointestinal tract. We have chosen to concentrate on individual genes and examine what is known about their regulation, attempting to link different studies together. ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199907000-00009

    authors: Kelly EJ,Sanderson IR

    更新日期:1999-07-01 00:00:00

  • Influence of nutrition therapy on the intestinal microbiome.

    abstract:PURPOSE OF REVIEW:This review describes the relationship between nutritional therapies and the intestinal microbiome of critically ill patients. RECENT FINDINGS:The intestinal microbiome of the critically ill displays a near complete loss of health-promoting microbiota with overgrowth of virulent healthcare-associated...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000348

    authors: Krezalek MA,Yeh A,Alverdy JC,Morowitz M

    更新日期:2017-03-01 00:00:00

  • Clinical efficacy of perioperative nutrition support.

    abstract::Despite a large number of published randomized prospective controlled clinical trials the indications for perioperative parenteral and enteral nutrition support remain controversial. This article reviews the reports of several recently published consensus conference reports and prospective randomized controlled trials...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199801000-00009

    authors: Satyanarayana R,Klein S

    更新日期:1998-01-01 00:00:00

  • Lipid metabolism in critical illness.

    abstract:PURPOSE OF REVIEW:This article describes recent findings regarding lipid metabolism in critical illness as well as in lipid therapy. RECENT FINDINGS:In critical illness, in the presence of a decrease in lipid absorption, adipose tissue lipolysis raises triglyceride levels. High-density lipoprotein and low-density lipo...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000253

    authors: Green P,Theilla M,Singer P

    更新日期:2016-03-01 00:00:00

  • L-Arginine therapy in cardiovascular pathologies: beneficial or dangerous?

    abstract:PURPOSE OF REVIEW:L-Arginine is the precursor for nitric oxide synthesis. In the brain, nitric oxide acts as a neurotransmitter; in the immune system, nitric oxide acts as a mediator of host defense; in the cardiovascular system, nitric oxide mediates the protective effects of the intact endothelium, acting as an endog...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3282f2b0c3

    authors: Böger RH

    更新日期:2008-01-01 00:00:00

  • Assessment of status.

    abstract::Laboratory methods for the measurement of micronutrients are usually based upon determinations in the peripheral blood. Most are relatively insensitive, but can screen for impending acute deficiency or toxicity. The metabolic responses to disease, injury and infection may alter the laboratory findings independently of...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199811000-00003

    authors: Fell GS,Talwar D

    更新日期:1998-11-01 00:00:00

  • Dysphagia and pharmacotherapy in older adults.

    abstract:PURPOSE OF REVIEW:The review summarizes current knowledge and recent findings about how to practically apply medication in patients with dysphagia and how swallowing function may be positively or negatively affected by drugs. RECENT FINDINGS:Oropharyngeal dysphagia is a major health problem in older persons and was re...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000523

    authors: Wirth R,Dziewas R

    更新日期:2019-01-01 00:00:00

  • Polypharmacy and malnutrition.

    abstract:PURPOSE OF REVIEW:Malnutrition and polypharmacy increase with age and polymorbidity and their relationship is based on a number of mechanisms. The occurrence of malnutrition in both in-patients and out-patients and its dependence on polymorbidity and age are well known, but the interrelation of polypharmacy and malnutr...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32835b612e

    authors: Zadak Z,Hyspler R,Ticha A,Vlcek J

    更新日期:2013-01-01 00:00:00

  • Alterations of protein metabolism in acromegaly.

    abstract:PURPOSE OF REVIEW:Growth hormone is a powerful anabolic hormone necessary for normal growth, but its importance in maintaining the cellular and protein mass in adult life is still unclear. However, it is viewed as a drug capable of combating the tissue loss and some metabolic derangements of aging. Growth hormone exces...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200501000-00008

    authors: Battezzati A,Bertoli S

    更新日期:2005-01-01 00:00:00