Alterations of protein metabolism in acromegaly.

Abstract:

PURPOSE OF REVIEW:Growth hormone is a powerful anabolic hormone necessary for normal growth, but its importance in maintaining the cellular and protein mass in adult life is still unclear. However, it is viewed as a drug capable of combating the tissue loss and some metabolic derangements of aging. Growth hormone excess causes acromegaly, a disease characterized by overgrowth of some tissues and multiple metabolic abnormalities. The purpose of this article is to review recent knowledge in acromegaly considering it as a model for clarifying aspects of growth hormone action on body composition, protein dynamics and molecular mechanisms in adult life. RECENT FINDINGS:Acromegaly induces well-documented changes in body fat (decreased), and bone density and water retention (increased), but there are less-clear changes in protein and body cell-mass accretion. Recent studies related insulin resistance to glucose metabolism to accelerated fat oxidation and described the reversibility of such alterations after surgical or pharmacologic therapy. Less attention was paid to changes in protein metabolism. Acromegalics are profoundly insulin-resistant to the antiproteolytic action of insulin, but amino acids are channelled towards protein synthesis because they are still normally spared from oxidation by insulin. This insulin resistance persists months after the surgical cure of acromegaly when glucose metabolism is already normalized. Recent studies suggested that increased use of fat for fuel by growth hormone may also promote protein anabolism and reduce amino acid oxidation. SUMMARY:Despite important advances in understanding molecular mechanisms in acromegaly, the specific effects on body cell and protein mass and the specific modulation of local protein dynamics remain poorly defined.

authors

Battezzati A,Bertoli S

doi

10.1097/00075197-200501000-00008

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

53-9

issue

1

eissn

1363-1950

issn

1473-6519

pii

00075197-200501000-00008

journal_volume

8

pub_type

杂志文章,评审
  • Stability and compatibility of histamine H2-receptor antagonists in parenteral nutrition mixtures.

    abstract:PURPOSE OF REVIEW:To examine the stability and compatibility of histamine H2-receptor antagonists in parenteral nutrition admixtures in order to provide well tolerated and effective therapy. RECENT FINDINGS:Many stability investigations were carried out before 2005, but no critical appraisal of published data has been...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3280ebb427

    authors: Puzovic M,Hardy G

    更新日期:2007-05-01 00:00:00

  • Modifying diet and physical activity to support pregnant women who are overweight or obese.

    abstract:PURPOSE OF REVIEW:Overweight and obesity represent a significant health burden during pregnancy, placing women and their infants at increased risk of adverse health outcomes. Although there is considerable observational literature describing the effect of gestational weight gain in pregnancy, research efforts have focu...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000170

    authors: Dodd JM,O'Brien CM,Grivell RM

    更新日期:2015-05-01 00:00:00

  • Age-related macular degeneration and antioxidant vitamins: recent findings.

    abstract:PURPOSE OF REVIEW:The purpose of the present review is to evaluate the most recent evidence for a role of antioxidant nutrients in the prevention or delay in progression of age-related macular degeneration (AMD), a major cause of visual impairment and blindness in the aging population. RECENT FINDINGS:Recent human stu...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32833308ff

    authors: Johnson EJ

    更新日期:2010-01-01 00:00:00

  • Vitamin D in the prevention and treatment of coronary heart disease.

    abstract:PURPOSE OF REVIEW:The pathogenesis of coronary heart disease is of multifactorial origin. Probably, not all risk factors are satisfactorily understood. This article outlines beneficial vitamin D effects on cardiac function and the vasculature. In addition, human data associating serum vitamin D metabolite levels or ora...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e328312c33f

    authors: Zittermann A,Koerfer R

    更新日期:2008-11-01 00:00:00

  • Effects of vitamin K on calcium and bone metabolism.

    abstract::The K vitamins, a group of napthoquinones, are required for the carboxylation of a limited number of proteins including the bone matrix protein osteocalcin. Vitamin K1 (phylloquinone) and vitamin K2 (menaquinones), differ regarding food source (green vegetables and fermented products, respectively), bioavailability an...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200111000-00003

    authors: Zittermann A

    更新日期:2001-11-01 00:00:00

  • Practical aspects of intensive insulinization in the intensive care unit.

    abstract:PURPOSE OF REVIEW:Strategies used for intensive insulin therapy of critically ill patients and differences of approach according to medical condition are reviewed. RECENT FINDINGS:Acceptance of proposed glycemic targets for critically ill patients has been tempered by uncertainties about benefit of strict glycemic con...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3280141ff4

    authors: Boulkina LS,Braithwaite SS

    更新日期:2007-03-01 00:00:00

  • Mechanisms regulating brain docosahexaenoic acid uptake: what is the recent evidence?

    abstract:PURPOSE OF REVIEW:To summarize recent advances pertaining to the mechanisms regulating brain docosahexaenoic acid (DHA) uptake. DHA is an omega-3 polyunsaturated fatty acid highly enriched in neuronal membranes and it is implicated in several important neurological processes. However, DHA synthesis is extremely limited...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000440

    authors: Chouinard-Watkins R,Lacombe RJS,Bazinet RP

    更新日期:2018-03-01 00:00:00

  • Can it all be done by enteral nutrition?

    abstract:PURPOSE OF REVIEW:During recent years techniques and metabolic considerations have been discussed intensively. One contributing reason is that results have not always been easy to interpret and introduce into clinical practice. Nutrition through the enteral and parenteral route has classically been compared, and this i...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200403000-00013

    authors: Hammarqvist F

    更新日期:2004-03-01 00:00:00

  • Protein metabolism in women and men: similarities and disparities.

    abstract:PURPOSE OF REVIEW:To provide an objective and comprehensive review of the recent literature addressing the effects of sex on protein metabolism. We also evaluate whether these differences can be attributed to physiology or methodology. Because of the developmental changes in hormonal milieu and body composition that oc...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283412343

    authors: Markofski MM,Volpi E

    更新日期:2011-01-01 00:00:00

  • Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.

    abstract:PURPOSE OF REVIEW:This review focuses upon the biology and metabolism of a trace component in foods called nicotinamide riboside. Nicotinamide riboside is a precursor of nicotinamide adenine dinucleotide (NAD), and is a source of Vitamin B3. Evidence indicates that nicotinamide riboside has unique properties as a Vitam...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32836510c0

    authors: Chi Y,Sauve AA

    更新日期:2013-11-01 00:00:00

  • Impact of stress and stress physiology during pregnancy on child metabolic function and obesity risk.

    abstract:PURPOSE OF REVIEW:To summarize recent conceptual frameworks and empirical findings addressing the role of prenatal stress and stress biology in the context of fetal programming of metabolic function and obesity risk. RECENT FINDINGS:The link between stress exposure and adverse health outcomes is well established. Grow...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32835e8d80

    authors: Entringer S

    更新日期:2013-05-01 00:00:00

  • Iron and brain functions.

    abstract:PURPOSE OF REVIEW:The purpose of this study is to highlight recent research findings that advance our understanding of the relation between iron status and neural functioning. RECENT FINDINGS:Recent findings have helped to answer questions pertaining to the interrelationship of iron and neural functioning in three pri...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283653ef8

    authors: Murray-Kolb LE

    更新日期:2013-11-01 00:00:00

  • Preoperative nutritional support at home in head and neck cancer patients: from nutritional benefits to the prevention of the alcohol withdrawal syndrome.

    abstract:PURPOSE OF REVIEW:Preoperative nutritional support in severely malnourished patients decreases complications after major surgery. This review summarizes previous studies on head and neck cancer patients undergoing surgery, and offers recommendations on preoperative nutritional support based on the literature and our ex...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200207000-00013

    authors: Bertrand PC,Piquet MA,Bordier I,Monnier P,Roulet M

    更新日期:2002-07-01 00:00:00

  • Some interactions between gastrointestinal function and fluid and electrolyte homeostasis.

    abstract:PURPOSE OF REVIEW:The gastrointestinal tract plays an important role in the maintenance of fluid and electrolyte balance, and its diseases cause disturbances in that balance. Conversely, fluid and electrolyte disorders may disturb gastrointestinal function. The purpose of this review is to highlight some recent literat...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200503000-00015

    authors: Macafee DA,Allison SP,Lobo DN

    更新日期:2005-03-01 00:00:00

  • Dietary approaches to assessing iron-related nutrition.

    abstract:PURPOSE OF REVIEW:Both dietary and nondietary factors contribute to iron deficiency, the most common nutritional deficiency worldwide. Identifying dietary factors associated with iron deficiency is challenging due to the number of components in food affecting iron absorption. This review describes recent advances in di...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e328364f382

    authors: Beck KL,Heath AL

    更新日期:2013-11-01 00:00:00

  • Influence of nutrition therapy on the intestinal microbiome.

    abstract:PURPOSE OF REVIEW:This review describes the relationship between nutritional therapies and the intestinal microbiome of critically ill patients. RECENT FINDINGS:The intestinal microbiome of the critically ill displays a near complete loss of health-promoting microbiota with overgrowth of virulent healthcare-associated...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000348

    authors: Krezalek MA,Yeh A,Alverdy JC,Morowitz M

    更新日期:2017-03-01 00:00:00

  • Clinical efficacy of perioperative nutrition support.

    abstract::Despite a large number of published randomized prospective controlled clinical trials the indications for perioperative parenteral and enteral nutrition support remain controversial. This article reviews the reports of several recently published consensus conference reports and prospective randomized controlled trials...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199801000-00009

    authors: Satyanarayana R,Klein S

    更新日期:1998-01-01 00:00:00

  • Assessing nutritional status in cancer: role of the Patient-Generated Subjective Global Assessment.

    abstract:PURPOSE OF REVIEW:The Scored Patient-Generated Subjective Global Assessment (PG-SGA) is used internationally as the reference method for proactive risk assessment (screening), assessment, monitoring and triaging for interventions in patients with cancer. This review aims to explain the rationale behind and data support...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000389

    authors: Jager-Wittenaar H,Ottery FD

    更新日期:2017-09-01 00:00:00

  • Two elephants in the room: new hybrid nuclear magnetic resonance and mass spectrometry approaches for metabolomics.

    abstract:PURPOSE OF REVIEW:This review describes some of the advances made over the past year in NMR-based metabolomics for the elucidation of known and unknown compounds, including new ways of how to combine this information with high-resolution mass spectrometry. RECENT FINDINGS:A new method allows the back-calculation of ma...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000206

    authors: Bingol K,Brüschweiler R

    更新日期:2015-09-01 00:00:00

  • Nutritional assessment in the hospitalized patient.

    abstract:PURPOSE OF REVIEW:Malnutrition is highly prevalent in hospitalized patients. Despite this, it is not routinely assessed in most hospitals worldwide. One of the reasons that might explain this fact is that there is no gold-standard nutritional assessment tool, and much has been written advocating this or that technique....

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200309000-00006

    authors: Waitzberg DL,Correia MI

    更新日期:2003-09-01 00:00:00

  • Potential intracellular targets for anabolic/anti-catabolic therapies.

    abstract::The intracellular signalling pathways controlling muscle protein synthesis and proteolysis are potential targets for anabolic/anti-catabolic therapy. In this review, we consider both the potentiation of the effect of anabolic hormones and suppression of the catabolic action of cytokines. Potential candidates, in parti...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199905000-00004

    authors: Palmer RM,Thompson MG

    更新日期:1999-05-01 00:00:00

  • The low FODMAP diet: fundamental therapy in the management of irritable bowel syndrome.

    abstract:PURPOSE OF REVIEW:The low FODMAP diet is now recognized as first-line therapy for treatment of irritable bowel syndrome (IBS) symptoms including abdominal pain, gas, bloating, diarrhea and or constipation. This information must be disseminated for application to clinical practice. RECENT FINDINGS:There are many people...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000398

    authors: Ireton-Jones C

    更新日期:2017-09-01 00:00:00

  • Dietary nitrate as modulator of physical performance and cardiovascular health.

    abstract:PURPOSE OF REVIEW:Early interventional trials reported improvements in cardiac and exercise outcomes with inorganic nitrate ingestion. The current review aims to provide a brief update of recent evidence regarding ergogenic and cardiovascular effects of dietary nitrate and practical recommendations. RECENT FINDINGS:Re...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000414

    authors: Kerley CP

    更新日期:2017-11-01 00:00:00

  • Nutrition support in patients with multiple organ failure.

    abstract::The problem with any attempt to feed patients in multiple organ failure is that, because of an ongoing inflammatory process, the conventional techniques of supplying energy and protein do not maintain lean tissue mass. In addition, the conventional markers of nutritional status, both anthropometric (body mass and comp...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199803000-00012

    authors: Campbell IT

    更新日期:1998-03-01 00:00:00

  • Diet of lactating women and allergic reactions in their infants.

    abstract:PURPOSE OF REVIEW:To evaluate whether the diet of lactating women modulates the development of allergic disease in their children. RECENT FINDINGS:Although maternal avoidance of common food protein allergens was previously recommended for lactating women with infants predisposed to allergic disease, recent expert revi...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000222113.46042.50

    authors: Palmer DJ,Makrides M

    更新日期:2006-05-01 00:00:00

  • Early adiposity rebound: review of papers linking this to subsequent obesity in children and adults.

    abstract:PURPOSE OF REVIEW:Improving our understanding of factors driving fat gain in young children should increase our ability to manage the rising problem of obesity. Accordingly, studies associating timing of adiposity rebound with later obesity are reviewed. RECENT FINDINGS:Investigations in many countries have confirmed ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000168391.60884.93

    authors: Taylor RW,Grant AM,Goulding A,Williams SM

    更新日期:2005-11-01 00:00:00

  • Stearoyl-coenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferator-activated receptor-alpha: independent and interactive roles in the regulation of lipid metabolism.

    abstract:PURPOSE OF REVIEW:With the increasing incidence of obesity today, related complications such as diabetes, insulin resistance and hepatic steatosis are also becoming major concerns. Since these conditions share a common factor, aberrations in lipid metabolism, understanding the molecular changes that lead to abnormal li...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000214564.59815.af

    authors: Sampath H,Ntambi JM

    更新日期:2006-03-01 00:00:00

  • L-Arginine therapy in cardiovascular pathologies: beneficial or dangerous?

    abstract:PURPOSE OF REVIEW:L-Arginine is the precursor for nitric oxide synthesis. In the brain, nitric oxide acts as a neurotransmitter; in the immune system, nitric oxide acts as a mediator of host defense; in the cardiovascular system, nitric oxide mediates the protective effects of the intact endothelium, acting as an endog...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3282f2b0c3

    authors: Böger RH

    更新日期:2008-01-01 00:00:00

  • Nutrient interaction for optimal protein anabolism in resistance exercise.

    abstract:PURPOSE OF REVIEW:The rapid muscle loss that accompanies varying diseased states (cachexia) is due to an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown In the current review, we will discuss and summarize recent evidence in order to provide practical recommendations on exercise and nutrie...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283516850

    authors: Breen L,Phillips SM

    更新日期:2012-05-01 00:00:00

  • Plant-derived phenolic antioxidants.

    abstract::Antioxidant nutrients are important for limiting damaging oxidative reactions in cells, which may predispose to the development of major clinical conditions such as heart disease and cancer. There is great interest in the possibility that the antioxidant potential of plant-derived phenolic compounds, such as flavonoid...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200011000-00006

    authors: Duthie G,Crozier A

    更新日期:2000-11-01 00:00:00