Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.

Abstract:

PURPOSE OF REVIEW:This review focuses upon the biology and metabolism of a trace component in foods called nicotinamide riboside. Nicotinamide riboside is a precursor of nicotinamide adenine dinucleotide (NAD), and is a source of Vitamin B3. Evidence indicates that nicotinamide riboside has unique properties as a Vitamin B3. We review knowledge of the metabolism of this substance, as well as recent work suggesting novel health benefits that might be associated with nicotinamide riboside taken in larger quantities than is found naturally in foods. RECENT FINDINGS:Recent work investigating the effects of nicotinamide riboside in yeast and mammals established that it is metabolized by at least two types of metabolic pathways. The first of these is degradative and produces nicotinamide. The second pathway involves kinases called nicotinamide riboside kinases (Nrk1 and Nrk2, in humans). The likely involvement of the kinase pathway is implicated in the unique effects of nicotinamide riboside in raising tissue NAD concentrations in rodents and for potent effects in eliciting insulin sensitivity, mitochondrial biogenesis, and enhancement of sirtuin functions. Additional studies with nicotinamide riboside in models of Alzheimer's disease indicate bioavailability to brain and protective effects, likely by stimulation of brain NAD synthesis. SUMMARY:Initial studies have clarified the potential for a lesser-known Vitamin B3 called nicotinamide riboside that is available in selected foods, and possibly available to humans by supplements. It has properties that are insulin sensitizing, enhancing to exercise, resisting to negative effects of high-fat diet, and neuroprotecting.

authors

Chi Y,Sauve AA

doi

10.1097/MCO.0b013e32836510c0

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

657-61

issue

6

eissn

1363-1950

issn

1473-6519

journal_volume

16

pub_type

杂志文章,评审
  • Dysphagia and pharmacotherapy in older adults.

    abstract:PURPOSE OF REVIEW:The review summarizes current knowledge and recent findings about how to practically apply medication in patients with dysphagia and how swallowing function may be positively or negatively affected by drugs. RECENT FINDINGS:Oropharyngeal dysphagia is a major health problem in older persons and was re...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000523

    authors: Wirth R,Dziewas R

    更新日期:2019-01-01 00:00:00

  • Selenium and glutamine supplements: where are we heading? A critical care perspective.

    abstract:PURPOSE OF REVIEW:There is considerable interest in glutamine and selenium in critical care as both offer the potential to enhance host defences, through different but complimentary mechanisms and may reduce subsequent infections and mortality. The SIGNET trial (randomized controlled factorial trial) is the largest, cr...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32833617cd

    authors: Andrews PJ

    更新日期:2010-03-01 00:00:00

  • Infection control issues of enteral feeding systems.

    abstract::Enteral feeding systems provide a mechanism for nutritional support for patients who may be unable to tolerate oral dietary sustenance. This review takes into account recent infection control issues relating to enteral feeding systems. The review is organized into the following areas of emphasis: infections associated...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200009000-00006

    authors: Marion ND,Rupp ME

    更新日期:2000-09-01 00:00:00

  • Colon cancer therapy: new perspectives of nutritional manipulations using polyunsaturated fatty acids.

    abstract:PURPOSE OF REVIEW:Recent advances in the development of new therapeutic strategies combining conventional adjuvant radio/chemotherapy with nutritional manipulations with n-3 polyunsaturated fatty acids (PUFAs) are presented. RECENT FINDINGS:Studies in cell culture and tumour-bearing animals have reported the ability o...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3281e2c9d4

    authors: Dupertuis YM,Meguid MM,Pichard C

    更新日期:2007-07-01 00:00:00

  • Lipid metabolism in critical illness.

    abstract:PURPOSE OF REVIEW:This article describes recent findings regarding lipid metabolism in critical illness as well as in lipid therapy. RECENT FINDINGS:In critical illness, in the presence of a decrease in lipid absorption, adipose tissue lipolysis raises triglyceride levels. High-density lipoprotein and low-density lipo...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000253

    authors: Green P,Theilla M,Singer P

    更新日期:2016-03-01 00:00:00

  • Fluid and electrolytes in the elderly.

    abstract:PURPOSE OF REVIEW:The intake of water and electrolytes is inseparable from the ingestion of nutrients by normal or artificial means. Recent reports have agreed in criticizing the poor standards of practice and of training in the management of fluid and electrolyte balance, resulting in a large amount of avoidable morbi...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200401000-00006

    authors: Allison SP,Lobo DN

    更新日期:2004-01-01 00:00:00

  • Assessment of intramuscular triglycerides: contribution to metabolic abnormalities.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to highlight recent methodological advances that have helped us to understand the role of intramuscular triglycerides in human health as well as prevention and treatment of disease. In addition to both invasive (muscle biopsy) and noninvasive methods, techniques to assess...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000241664.38385.12

    authors: Dubé J,Goodpaster BH

    更新日期:2006-09-01 00:00:00

  • Vitamin E: absorption, plasma transport and cell uptake.

    abstract:PURPOSE OF REVIEW:Large-scale clinical trials have failed to demonstrate a benefit for vitamin E supplementation in cardiovascular prevention. This contrasts with previous epidemiological studies indicating that individuals with high vitamin E status benefit from protection against chronic illnesses, including cardiova...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200503000-00005

    authors: Hacquebard M,Carpentier YA

    更新日期:2005-03-01 00:00:00

  • Preoperative nutritional support at home in head and neck cancer patients: from nutritional benefits to the prevention of the alcohol withdrawal syndrome.

    abstract:PURPOSE OF REVIEW:Preoperative nutritional support in severely malnourished patients decreases complications after major surgery. This review summarizes previous studies on head and neck cancer patients undergoing surgery, and offers recommendations on preoperative nutritional support based on the literature and our ex...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200207000-00013

    authors: Bertrand PC,Piquet MA,Bordier I,Monnier P,Roulet M

    更新日期:2002-07-01 00:00:00

  • Nutrition support in critically ill septic patients.

    abstract:PURPOSE OF REVIEW:Infection and sepsis remain major challenges in the critically ill. How nutritional therapy can effect real clinical outcomes is not easily apparent from the clinical data. Despite reducing infectious incidence, many studies show little difference in meaningful clinical outcomes. RECENT FINDINGS:Conf...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200303000-00009

    authors: Griffiths RD

    更新日期:2003-03-01 00:00:00

  • The role of probiotics in gastrointestinal surgery.

    abstract:PURPOSE OF REVIEW:Postoperative complications in gastrointestinal elective surgery have been described as low. In certain circumstances, however, such as those including high-risk patients, the incidence is higher. In such situations, bacteremia and infectious complications may be caused by translocation of either gast...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000241674.55417.c9

    authors: Correia MI,Nicoli JR

    更新日期:2006-09-01 00:00:00

  • Dietary nitrate as modulator of physical performance and cardiovascular health.

    abstract:PURPOSE OF REVIEW:Early interventional trials reported improvements in cardiac and exercise outcomes with inorganic nitrate ingestion. The current review aims to provide a brief update of recent evidence regarding ergogenic and cardiovascular effects of dietary nitrate and practical recommendations. RECENT FINDINGS:Re...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000414

    authors: Kerley CP

    更新日期:2017-11-01 00:00:00

  • Genetic and metabolic determinants of human epigenetic variation.

    abstract:PURPOSE OF REVIEW:Epigenetics has emerged in recent years as one of the most important biological mechanisms linking exposures across the life course to long-term health. This article reviews recent developments in our understanding of the metabolic and genetic determinants of epigenetic variation in human populations....

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000194

    authors: Haggarty P

    更新日期:2015-07-01 00:00:00

  • Using trehalose to prevent and treat metabolic function: effectiveness and mechanisms.

    abstract:PURPOSE OF REVIEW:Trehalose is a disaccharide with manifold industrial, commercial and biomedical uses. In the decade following its initial definition as an autophagy-inducing agent, significant advances have been realized in regard to the applicable clinical and preclinical contexts in which trehalose can be deployed....

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000568

    authors: Zhang Y,DeBosch BJ

    更新日期:2019-07-01 00:00:00

  • Curcumin and arterial function in health and disease: impact on oxidative stress and inflammation.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to provide a concise overview of the polyphenol curcumin for improving arterial health, specifically endothelial function and arterial stiffness, to reduce cardiovascular disease (CVD) risk and to highlight potential mechanisms of action by which curcumin may improve arte...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000598

    authors: Fleenor BS,Carlini NA,Campbell MS

    更新日期:2019-11-01 00:00:00

  • Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection.

    abstract:PURPOSE OF REVIEW:To summarize recent findings that docosahexaenoate (DHA) is the precursor of stereospecific derivatives with anti-inflammatory and cytoprotective properties. RECENT FINDINGS:The docosahexaenoate-derived mediator neuroprotectin D1 is formed in retinal pigment epithelial cells when confronted with oxid...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32802b7030

    authors: Bazan NG

    更新日期:2007-03-01 00:00:00

  • Vitamin E and nonalcoholic fatty liver disease.

    abstract:PURPOSE OF REVIEW:Oxidative stress plays a central role in the transition from simple steatosis to nonalcoholic steatohepatitis (NASH). An effective therapeutic strategy is to target reduction in oxidative stress in NASH patients. The aim of this review is to discuss the role of oxidative stress in NASH and biological ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e328357f747

    authors: Pacana T,Sanyal AJ

    更新日期:2012-11-01 00:00:00

  • Home artificial nutrition.

    abstract::Home artificial nutrition is a mature technology that has been with us for over a quarter of a century. Its use appears to be more widespread in the USA than in other western countries. Issues of outcome, ethics, and quality of life are increasingly important. Complications continue to be reported, some newly recogniz...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199909000-00006

    authors: Lipman TO

    更新日期:1999-09-01 00:00:00

  • Dissecting the energy needs of the body.

    abstract::The majority of the resting energy expenditure can be explained by the energy needs of a few highly metabolic organs, making up a small percentage of the body by weight. The relationship of the specific size, individual metabolism, and proportional contribution to the actual body weight and total energy expenditure fo...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200103000-00011

    authors: McClave SA,Snider HL

    更新日期:2001-03-01 00:00:00

  • Polypharmacy and malnutrition.

    abstract:PURPOSE OF REVIEW:Malnutrition and polypharmacy increase with age and polymorbidity and their relationship is based on a number of mechanisms. The occurrence of malnutrition in both in-patients and out-patients and its dependence on polymorbidity and age are well known, but the interrelation of polypharmacy and malnutr...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32835b612e

    authors: Zadak Z,Hyspler R,Ticha A,Vlcek J

    更新日期:2013-01-01 00:00:00

  • Lipid transporters: membrane transport systems for cholesterol and fatty acids.

    abstract::Lipophilic molecules can passively diffuse across cell membranes, a process that is driven by the concentration gradient, by availability of acceptors to facilitate desorption from the bilayer, and by cellular metabolism. However, evidence has accumulated that supports the existence of specialized, protein-facilitated...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200007000-00003

    authors: Abumrad NA,Sfeir Z,Connelly MA,Coburn C

    更新日期:2000-07-01 00:00:00

  • AMP-activated protein kinase, fatty acid metabolism, and insulin sensitivity.

    abstract:PURPOSE OF REVIEW:Insulin resistance is an important risk factor for metabolic diseases such as type 2 diabetes, cardiovascular disease and certain cancers. A common characteristic of strategies that improve insulin sensitivity involves the activation of the energy sensing enzyme of the cell, AMP-activated protein kina...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000380

    authors: Smith BK,Steinberg GR

    更新日期:2017-07-01 00:00:00

  • Ergonomic and economic aspects of total parenteral nutrition.

    abstract:PURPOSE OF REVIEW:Ergonomics in total parenteral nutrition include the work performed in the (hospital) pharmacy and on the medical ward. This article reviews the developments in total parenteral nutrition ergonomics and the related cost-savings. RECENT FINDINGS:Research focuses on the ergonomic advantages of multi-co...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000214574.82686.ac

    authors: Genton L,Mühlebach S,Dupertuis YM,Pichard C

    更新日期:2006-03-01 00:00:00

  • Indices of diet quality.

    abstract:PURPOSE OF REVIEW:The present review provides an overview of the different dietary quality indices in use. In the first decades, most indices were developed for the general adult population and were based on the American dietary guidelines and the Mediterranean diet. This review focuses on new, other dietary quality in...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32830a49db

    authors: Fransen HP,Ocké MC

    更新日期:2008-09-01 00:00:00

  • Impact of stress and stress physiology during pregnancy on child metabolic function and obesity risk.

    abstract:PURPOSE OF REVIEW:To summarize recent conceptual frameworks and empirical findings addressing the role of prenatal stress and stress biology in the context of fetal programming of metabolic function and obesity risk. RECENT FINDINGS:The link between stress exposure and adverse health outcomes is well established. Grow...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32835e8d80

    authors: Entringer S

    更新日期:2013-05-01 00:00:00

  • Angiotensin II as candidate of cardiac cachexia.

    abstract:PURPOSE OF REVIEW:Congestive heart failure is increasing in prevalence and represents a major public health problem. The syndrome of advanced heart failure often includes muscle wasting, commonly termed cardiac cachexia, which is a predictor of poor outcome. Mechanisms of cardiac cachexia are poorly understood, but the...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000222103.29009.70

    authors: Delafontaine P,Akao M

    更新日期:2006-05-01 00:00:00

  • Measuring body fat distribution and content in humans.

    abstract:PURPOSE OF REVIEW:In this review methods to measure the content and distribution of body fat or adipose tissue in humans are examined. The review particularly emphasizes methods to characterize regional fat distribution and ectopic fat (fat contained within other tissues) including specific applications and implication...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200209000-00005

    authors: Goodpaster BH

    更新日期:2002-09-01 00:00:00

  • Stearoyl-coenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferator-activated receptor-alpha: independent and interactive roles in the regulation of lipid metabolism.

    abstract:PURPOSE OF REVIEW:With the increasing incidence of obesity today, related complications such as diabetes, insulin resistance and hepatic steatosis are also becoming major concerns. Since these conditions share a common factor, aberrations in lipid metabolism, understanding the molecular changes that lead to abnormal li...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000214564.59815.af

    authors: Sampath H,Ntambi JM

    更新日期:2006-03-01 00:00:00

  • The Geriatric Nutritional Risk Index.

    abstract:PURPOSE OF REVIEW:A new nutrition-related risk assessment tool, the Geriatric Nutritional Risk Index (GNRI), has been recently proposed. The aim of this review is to summarize current evidences on the use of this tool with particular focus on the rationales of its application in elderly healthcare. RECENT FINDINGS:Str...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283186f59

    authors: Cereda E,Pedrolli C

    更新日期:2009-01-01 00:00:00

  • Meal patterns and childhood obesity.

    abstract:PURPOSE OF REVIEW:To summarize the literature concerning the relationship between meal patterns and childhood obesity. Literature searches of MEDLINE and the Cochrane Library were performed in October 2009 for studies published in the last 18-24 months. RECENT FINDINGS:Available data indicate that not only meal compos...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32833681a2

    authors: Patro B,Szajewska H

    更新日期:2010-05-01 00:00:00