Abstract:
PURPOSE OF REVIEW:Dyspepsia is a common disorder that presents as persistent or recurrent abdominal pain or discomfort in the upper abdomen and originates from organic or functional causes. Heterogeneous disorders, physiopathological, psychosomatic, sociocultural, demographic and genetic components have a great impact on its presentation. Physiopathological elements and the influence of nutrients on symptomatology are discussed to help establish clearer guidelines for treatment. RECENT FINDINGS:Gastric emptying is affected by physiological, pharmacological and dietary factors and is translated into symptoms and signs such as anorexia, nausea, vomiting, weight loss and abdominal pain. Liquid or solid meals may cause early or delayed emptying, which is associated with symptoms of postprandial fullness. Abnormal glucose and electrolyte serum values may also cause transitory emptying delay. Fatty and acid nutrients have also been reported to aggravate symptoms of functional dyspepsia, especially after large meals. Studies have also pointed at food sensibility and the effect of Helicobacter pylori infection on gastric emptying in symptomatic patients. Patients may suffer antral hypomotility and total/partial postingestion pattern conversion. Spinal brain axis dysfunction caused by peripheral inflammation is associated with gastric dysmotility. An association between symptoms and functional polymorphisms is pending further clarification. It has been questioned whether the genotype is associated with a specific physiopathological mechanism, postinfectious functional disorders or psychological/social alterations. SUMMARY:The treatment of dyspepsia is empiric and is directed at improving symptoms associated with alterations in emptying, postprandial accommodation, hypersensibility and hyperalgesia. Further studies are required to correlate symptoms with food kinetics at the initial postfood ingestion stages.
journal_name
Curr Opin Clin Nutr Metab Carejournal_title
Current opinion in clinical nutrition and metabolic careauthors
de Baptista GAdoi
10.1097/01.mco.0000179165.33323.18subject
Has Abstractpub_date
2005-09-01 00:00:00pages
562-7issue
5eissn
1363-1950issn
1473-6519pii
00075197-200509000-00012journal_volume
8pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:There is a need to develop a screening tool to assist clinical staff in deciding whether or not a patient in the ICU should be given nutrition support. The purpose of this review is to analyze the recent randomized trials in this context. RECENT FINDINGS:Five trials describe the effect of early suppl...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000041
更新日期:2014-03-01 00:00:00
abstract::Studies of many different rodent models of muscle wasting have indicated that accelerated proteolysis via the ubiquitin-proteasome pathway is the principal cause of muscle atrophy induced by fasting, cancer cachexia, metabolic acidosis, denervation, disuse, diabetes, sepsis, burns, hyperthyroidism and excess glucocort...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200105000-00003
更新日期:2001-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Malnutrition is highly prevalent in hospitalized patients. Despite this, it is not routinely assessed in most hospitals worldwide. One of the reasons that might explain this fact is that there is no gold-standard nutritional assessment tool, and much has been written advocating this or that technique....
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200309000-00006
更新日期:2003-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Here, we discuss recent work focused on the role of activating transcription factor 4 (ATF4) in skeletal muscle atrophy. RECENT FINDINGS:Muscle atrophy involves and requires widespread changes in skeletal muscle gene expression; however, the transcriptional regulatory proteins responsible for those c...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000362
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Congestive heart failure is increasing in prevalence and represents a major public health problem. The syndrome of advanced heart failure often includes muscle wasting, commonly termed cardiac cachexia, which is a predictor of poor outcome. Mechanisms of cardiac cachexia are poorly understood, but the...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000222103.29009.70
更新日期:2006-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Dietary fiber may play a role in obesity prevention through reduction of body weight and control of appetite, however, not all fibers are created equally, and characteristics of fiber such as viscosity, fermentability and solubility may affect appetite differently. RECENT FINDINGS:Although early stud...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000502
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review describes some of the advances made over the past year in NMR-based metabolomics for the elucidation of known and unknown compounds, including new ways of how to combine this information with high-resolution mass spectrometry. RECENT FINDINGS:A new method allows the back-calculation of ma...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000206
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The obesity paradox is a highly controversial concept that may be attributed to methodological limitations related to its identification. One of the primary concerns is the use of BMI to define obesity. This index does not differentiate lean versus adipose tissue compartments (i.e. body composition) c...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000216
更新日期:2015-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Food allergy affects up to 10% of preschool children, and continues to increase in prevalence in many countries, resulting in a major public health issue, with practical implications for the food industry, educational establishments and healthcare systems. RECENT FINDINGS:The need to distinguish betw...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000052
更新日期:2014-05-01 00:00:00
abstract:PURPOSE OF REVIEW:This article is intended to briefly overview available methodological approaches for the study of regional metabolism in man in vivo, and to summarize recent advances in this field of research. RECENT FINDINGS:Several methods have been developed and currently allow for the qualitative and quantitativ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000170756.71114.78
更新日期:2005-09-01 00:00:00
abstract::Arginine is a non-essential amino acid in mammals as judged from nitrogen balance study. Citrulline is synthesized from glutamate in the small intestine, whilst kidneys and some other tissues convert citrulline to arginine. Ornithine transcarbamylase and carbamylphosphate synthetase are expressed in liver and small in...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-199807000-00004
更新日期:1998-07-01 00:00:00
abstract:PURPOSE OF REVIEW:In this review methods to measure the content and distribution of body fat or adipose tissue in humans are examined. The review particularly emphasizes methods to characterize regional fat distribution and ectopic fat (fat contained within other tissues) including specific applications and implication...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200209000-00005
更新日期:2002-09-01 00:00:00
abstract::The liver plays a central role in the control of glucose production. It is also involved in the regulation of insulin secretion and sensitivity through neural pathways. This review will address recent developments in the mechanisms by which hepatic metabolism affects glucose homeostasis in health and disease. Oral glu...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200107000-00005
更新日期:2001-07-01 00:00:00
abstract:PURPOSE OF REVIEW:There is increasing clinical and pathophysiological evidence that a premature aging process is involved in the pathogenesis of systemic complications of many chronic organ diseases, which result in analogous phenotypes, including premature vascular aging, osteoporosis and muscle wasting. Novel develop...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000218
更新日期:2015-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Fructose malabsorption is associated with gastrointestinal symptoms. This review examines new findings on the physiology, assessment and therapy of fructose malabsorption in functional gastrointestinal disorders. RECENT FINDINGS:Additional GLUT transport mechanisms that regulate fructose absorption m...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328361c556
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The inflammatory response is essential in the response to pathogens. TNF-alpha, IL-1 and IL-6 are key mediators of the response. They initiate metabolic changes to provide nutrients for the immune system, from host tissues. These changes include hyperlipidemia and increased gluconeogenesis. Insulin re...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200209000-00015
更新日期:2002-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To understand the impact of microRNA on myogenesis and muscle wasting in order to provide valuable information for clinical investigation. RECENT FINDINGS:Muscle wasting increases the risk of morbidity/mortality in primary muscle diseases, secondary muscle disorders and elderly population. Muscle mas...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32835f81b9
更新日期:2013-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Metabolic syndrome (MetS) is associated with increased risk of obesity, type 2 diabetes mellitus and cardiovascular diseases. MetS prevalence has been associated with diet inadequacy. Conversely, the cumulative incidence of MetS has been inversely associated with a Mediterranean-style diet that includ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000412
更新日期:2017-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Until relatively recently, the only significant source of lactoferrin in the diet was human lactoferrin, provided in breast milk. Today, however, bovine lactoferrin, isolated by dairy technology, as well as recombinant human lactoferrin are commercially available and can be added to foods and clinical...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328328d13e
更新日期:2009-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The low FODMAP diet is now recognized as first-line therapy for treatment of irritable bowel syndrome (IBS) symptoms including abdominal pain, gas, bloating, diarrhea and or constipation. This information must be disseminated for application to clinical practice. RECENT FINDINGS:There are many people...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000398
更新日期:2017-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Recently, the US Food and Drug Administration and the European Medicines Agency approved the glucagon-like peptide 2 analogue, teduglutide, for the treatment of short bowel syndrome (SBS), and this review describes the physiological basis for its clinical use. RECENT FINDINGS:By affecting the intesti...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328363bce4
更新日期:2013-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review focuses upon the biology and metabolism of a trace component in foods called nicotinamide riboside. Nicotinamide riboside is a precursor of nicotinamide adenine dinucleotide (NAD), and is a source of Vitamin B3. Evidence indicates that nicotinamide riboside has unique properties as a Vitam...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32836510c0
更新日期:2013-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Postoperative complications in gastrointestinal elective surgery have been described as low. In certain circumstances, however, such as those including high-risk patients, the incidence is higher. In such situations, bacteremia and infectious complications may be caused by translocation of either gast...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000241674.55417.c9
更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:There are concerns about the rising incidence of obesity in children and their acceptance of healthy foods. Many factors affect children's food acceptance, the most salient are those enabling early exposure to culturally appropriate foods in the weaning or pre-weaning period. Parents, however, have al...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e3282f9e228
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The mortality and morbidity associated with severe acute malnutrition (SAM) remain high. A summary of recent studies that are of interest to clinicians treating children with SAM is provided. RECENT FINDINGS:Three important themes emerged in 2015: the use of anthropometry in the diagnosis of SAM and ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000269
更新日期:2016-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Folic acid is now considered an important functional food component: it lowers potentially toxic homocysteine, prevents birth defects and modulates the risk of several cancers. The complexity of interactions involved, however, means we still have much to learn about the role of folate and homocysteine...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000247468.18790.1e
更新日期:2006-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To understand the interest of functional food in low-income countries by analyzing various necessary factors. RECENT FINDINGS:Being on a low income would appear to relate most often to an unbalanced diet, both qualitatively and quantitatively, which may be damaging to health in the long term. Most ch...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000111
更新日期:2014-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Improving our understanding of factors driving fat gain in young children should increase our ability to manage the rising problem of obesity. Accordingly, studies associating timing of adiposity rebound with later obesity are reviewed. RECENT FINDINGS:Investigations in many countries have confirmed ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000168391.60884.93
更新日期:2005-11-01 00:00:00
abstract:PURPOSE OF REVIEW:New evidence has recently supported the notion that brown adipose tissue (BAT) is present in adult humans and can play a prominent role in the regulation of body weight and metabolism. This has renewed the efforts to understand the physiologic mechanisms by which BAT is activated, which in turn could ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000063
更新日期:2014-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Overweight and obesity represent a significant health burden during pregnancy, placing women and their infants at increased risk of adverse health outcomes. Although there is considerable observational literature describing the effect of gestational weight gain in pregnancy, research efforts have focu...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000170
更新日期:2015-05-01 00:00:00