Methodological approaches to the study of metabolism across individual tissues in man.

abstract：PURPOSE OF REVIEW:The present review aims to address the role of adipose tissue oxygen partial pressure (PO2) in the metabolic and endocrine derangements in conditions characterized by insulin resistance. RECENT FINDINGS:The balance between adipose tissue oxygen supply and its metabolic rate seems to determine adipose...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Goossens GH,Blaak EE

更新日期：2012-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review depicts recent developments concerning the role of the liver in control of carbohydrate and lipid utilization from ingestion to storage; it covers the liver's influence on food intake, post-absorptive nutrient metabolism and body weight. The mechanisms involved have implications for the pa...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Langhans W

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the recent advances in our understanding of fatty acids and lipids in paediatric nonalcoholic fatty liver disease (NAFLD) and their future implications. RECENT FINDINGS:Data have been accumulated to suggest that ceramides are the main drivers of hepatic insulin resistance in NAFLD, and in...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Mann JP,Feldstein AE,Nobili V

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity. RECENT FINDINGS:We outline recent studies revealing unrecognized mechanisms controlling beige adipocyte p...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： McQueen AE,Koliwad SK,Wang JC

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss transcriptional mechanisms regulating hepatic lipid metabolism. RECENT FINDINGS:Humans who are obese or have diabetes (NIDDM) or metabolic syndrome (MetS) have low blood and tissue levels of C20-22 polyunsaturated fatty acids (PUFAs). Although the impact of low C20-22 PUFAs on disease prog...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Jump DB

更新日期：2011-03-01 00:00:00

abstract：:Acute and chronic diseases are frequently characterized by alterations in energy metabolism that influence nutritional requirements and clinical care. Knowledge of the effect of disease on daily energy expenditure and its components is fundamental to understanding the impact of the disease process on energy balance. T...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Toth MJ

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article describes recent findings regarding lipid metabolism in critical illness as well as in lipid therapy. RECENT FINDINGS:In critical illness, in the presence of a decrease in lipid absorption, adipose tissue lipolysis raises triglyceride levels. High-density lipoprotein and low-density lipo...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Green P,Theilla M,Singer P

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This article aims at reviewing the recent findings that have been made concerning the crosstalk of carbohydrate metabolism with the generation of small, dense low-density lipoprotein (LDL) particles, which are known to be associated with an adverse cardiovascular risk profile. RECENT FINDINGS:Studies...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Gerber PA,Berneis K

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Size at birth is critical in determining life expectancy with both small and large neonates at risk of shortened life spans. This review examines the hormonal and nutritional drivers of intrauterine growth with emphasis on the role of foetal hormones as nutritional signals in utero. RECENT FINDINGS:N...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Sferruzzi-Perri AN,Vaughan OR,Forhead AJ,Fowden AL

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this overview is to highlight the multiple ways in which oxidative stress could be exacerbating muscle wasting. Understanding these interactions in vivo will assist in identifying opportunities for more targeted therapies to reduce skeletal muscle wasting. RECENT FINDINGS:There are many ex...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Arthur PG,Grounds MD,Shavlakadze T

更新日期：2008-07-01 00:00:00

abstract：:Lipids play an extraordinary range of roles in normal and deranged metabolism. In diabetes and obesity, lipids have often been seen just as impacting on the energy balance equation. New data are extending our understanding of how lipid subclasses influence carbohydrate and lipid metabolism at multiple control points: ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Storlien LH,Hulbert AJ,Else PL

更新日期：1998-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Lipidomic profiling of biological samples is increasing in nutritional research applications. 'Lipidomic analyses' however can be quite variable in specific methods and the type of information about the specific lipids that is revealed. The lack of defined and simple terminology to describe aspects of...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Aristizabal Henao JJ,Bradley RM,Duncan RE,Stark KD

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Improving our understanding of factors driving fat gain in young children should increase our ability to manage the rising problem of obesity. Accordingly, studies associating timing of adiposity rebound with later obesity are reviewed. RECENT FINDINGS:Investigations in many countries have confirmed ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Taylor RW,Grant AM,Goulding A,Williams SM

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Preventing unintentional weight and muscle loss is of crucial importance to maintain the condition and well-being of patients with cancer, improve treatment response and tolerance, and prolong survival. Anabolic resistance might explain why some cancer patients do not respond to nutritional interventi...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Engelen MP,van der Meij BS,Deutz NE

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Muscle protein synthesis (MPS) and muscle protein breakdown are simultaneous ongoing processes. Here, we examine evidence for how protein quality can affect exercise-induced muscle protein anabolism or protein balance (MPS minus muscle protein breakdown). Evidence is highlighted showing differences in...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Tang JE,Phillips SM

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the recent findings on metabolic monitoring and possible beneficial effects of an adequate nutrition therapy, based on indirect calorimetry as the golden standard to predict energy expenditure. RECENT FINDINGS:in the last decades, major steps are taken in the field of metabolism and nutriti...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： De Waele E,Honoré PM,Malbrain MLNG

更新日期：2018-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the results of new investigations that look at the efficacy of nutrient/training strategies on metabolism and athletic performance. RECENT FINDINGS:'Dietary periodization' involves the manipulation of macronutrient intake in association with changes in physical training. Such interventions...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Burke LM,Hawley JA

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Food allergy affects up to 10% of preschool children, and continues to increase in prevalence in many countries, resulting in a major public health issue, with practical implications for the food industry, educational establishments and healthcare systems. RECENT FINDINGS:The need to distinguish betw...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Turner PJ,Boyle RJ

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Obese individuals have impaired respiratory function relative to their normal-weight counterparts. Despite these negative effects, obesity is paradoxically associated with better survival in individuals with chronic obstructive pulmonary disease (COPD). The purpose of this review is to describe this '...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Guenette JA,Jensen D,O'Donnell DE

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the present review is to provide insights into the future therapeutic approaches to cancer-related muscle wasting that flow from the progressive knowledge of mechanisms regulating muscle mass in health and disease. RECENT FINDINGS:Cancer cachexia is a severely debilitating and life-threate...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Muscaritoli M,Bossola M,Bellantone R,Rossi Fanelli F

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:There is considerable interest in glutamine and selenium in critical care as both offer the potential to enhance host defences, through different but complimentary mechanisms and may reduce subsequent infections and mortality. The SIGNET trial (randomized controlled factorial trial) is the largest, cr...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Andrews PJ

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The main aim of this review is to summarize current knowledge of tumor protein p53-inducible nuclear protein 2 (TP53INP2) function and its role in skeletal muscle proteostasis. RECENT FINDINGS:Autophagy is directly involved in the regulation of skeletal muscle mass. Thus, excessive autophagy is assoc...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Sala D,Zorzano A

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Dyspepsia is a common disorder that presents as persistent or recurrent abdominal pain or discomfort in the upper abdomen and originates from organic or functional causes. Heterogeneous disorders, physiopathological, psychosomatic, sociocultural, demographic and genetic components have a great impact ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： de Baptista GA

更新日期：2005-09-01 00:00:00

abstract：:Catabolism of fat-free mass affects both the quality of life and survival of patients. Because of variations in fluid status during acute illness, changes in body weight are difficult to evaluate and interpret during treatment. Nutritional assessment should therefore evaluate fat-free and fat mass changes during metab...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Kyle UG,Pichard C

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of calorie restriction in humans is controversial. Recently, new data in monkeys and humans have provided new insights into the potential role of calorie restriction in longevity. RECENT FINDINGS:A study in rhesus monkeys showed a reduction in aging-associated mortality. A number of controll...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Morley JE,Chahla E,Alkaade S

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The concentrations of plasma-free amino acids, such as branched-chain amino acids and aromatic amino acids, are associated with visceral obesity, insulin resistance, and the future development of diabetes and cardiovascular diseases. This review discusses recent progress in the early assessment of the...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Nagao K,Yamakado M

更新日期：2016-09-01 00:00:00

abstract：:Advances in separation science are leading to more sensitive and more specific analysis of the complex mixtures of metabolites, vitamins and nutrients found in biofluids. Recent developments include capillary electrokinetic separations such as capillary electrophoresis, and the linking of separation methods to new for...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Perrett D

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Autophagy is an evolutionarily conserved cellular programme for the turnover of organelles, proteins, and other macromolecules, involving the lysosomal degradation pathway. Emerging evidence suggests that autophagy can play a central role in human metabolism as well as impact diverse cellular processe...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Ryter SW,Koo JK,Choi AM

更新日期：2014-07-01 00:00:00

abstract：:The underlying causative agent in the majority of patients with chronic liver disease is ethanol; the rest of the cases are largely viral in aetiology (hepatitis B or C viruses). Nutrition supplementation improves the quality of life and decreases morbidity in chronic liver disease, but evidence that it prolongs long-...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Gopalan S,Saran S,Sengupta R

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Skeletal muscle and lean body mass may be vital to prognosis and functional recovery in chronic and acute illness, particularly in conditions in which muscle atrophy is prevalent. Ultrasound provides a precise and expedient method to measure muscle mass and changes in skeletal muscle at the bedside. ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Mourtzakis M,Wischmeyer P

更新日期：2014-09-01 00:00:00