Antiaging, longevity and calorie restriction.

Abstract:

PURPOSE OF REVIEW:The role of calorie restriction in humans is controversial. Recently, new data in monkeys and humans have provided new insights into the potential role of calorie restriction in longevity. RECENT FINDINGS:A study in rhesus monkeys showed a reduction in aging-associated mortality. A number of controlled studies have suggested a variety of beneficial effects during studies of 6-12 months in humans. Major negative effects in humans were loss of muscle mass, muscle strength and loss of bone. SUMMARY:Dietary restriction in rodents has not been shown to be effective when started in older rodents. Weight loss in humans over 60 years of age is associated with increased mortality, hip fracture and increased institutionalization. Calorie restriction in older persons should be considered experimental and potentially dangerous. Exercise at present appears to be a preferable treatment for older persons.

authors

Morley JE,Chahla E,Alkaade S

doi

10.1097/MCO.0b013e3283331384

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

40-5

issue

1

eissn

1363-1950

issn

1473-6519

journal_volume

13

pub_type

杂志文章,评审
  • Drug-nutrient interaction in clinical nutrition.

    abstract::Drug-nutrient interactions have been recognized for decades. It is known that improper management of some of these interactions may lead to therapeutic failure or cause serious adverse effects to the patients. While most of the known drug-nutrient interactions involve changes in oral bioavailabilities and absorption o...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200205000-00014

    authors: Chan LN

    更新日期:2002-05-01 00:00:00

  • Neural systems controlling food intake and energy balance in the modern world.

    abstract:PURPOSE OF REVIEW:Obesity continues to increase around the globe, and creates a major health problem because of its comorbidities such as diabetes and cardiovascular disease. Considering that the major cause of most human obesities is the modern lifestyle in a rapidly changing environment, this suggests that the battle...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200311000-00002

    authors: Berthoud HR

    更新日期:2003-11-01 00:00:00

  • Short-term and long-term consequences and concerns regarding valid assessment of vitamin D deficiency: comparison of recent food supplementation and clinical guidance reports.

    abstract:PURPOSE OF REVIEW:The function and use of vitamin D supplementation has become very controversial. This review attempts to provide a balanced perspective with respect to the experimental findings published in the past 18 months. RECENT FINDINGS:The recent contrasts between the Institute of Medicine (IOM) report and th...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32834be798

    authors: Hollis BW

    更新日期:2011-11-01 00:00:00

  • Protein metabolism in women and men: similarities and disparities.

    abstract:PURPOSE OF REVIEW:To provide an objective and comprehensive review of the recent literature addressing the effects of sex on protein metabolism. We also evaluate whether these differences can be attributed to physiology or methodology. Because of the developmental changes in hormonal milieu and body composition that oc...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283412343

    authors: Markofski MM,Volpi E

    更新日期:2011-01-01 00:00:00

  • Iron and brain functions.

    abstract:PURPOSE OF REVIEW:The purpose of this study is to highlight recent research findings that advance our understanding of the relation between iron status and neural functioning. RECENT FINDINGS:Recent findings have helped to answer questions pertaining to the interrelationship of iron and neural functioning in three pri...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283653ef8

    authors: Murray-Kolb LE

    更新日期:2013-11-01 00:00:00

  • The low FODMAP diet: fundamental therapy in the management of irritable bowel syndrome.

    abstract:PURPOSE OF REVIEW:The low FODMAP diet is now recognized as first-line therapy for treatment of irritable bowel syndrome (IBS) symptoms including abdominal pain, gas, bloating, diarrhea and or constipation. This information must be disseminated for application to clinical practice. RECENT FINDINGS:There are many people...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000398

    authors: Ireton-Jones C

    更新日期:2017-09-01 00:00:00

  • Clogbusting: time for a concerted approach to catheter occlusions?

    abstract:PURPOSE OF REVIEW:Occlusions of central venous catheters in service are frequent, but the random nature of the problem has resulted in a piecemeal approach to solving it. The purpose of this review is to examine what is known from past and recent publications and to recommend strategies for future investigations. RECE...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000165006.39449.1f

    authors: Hardy G,Ball P

    更新日期:2005-05-01 00:00:00

  • Nutrients and dyspepsia: paradigms and reality.

    abstract:PURPOSE OF REVIEW:Dyspepsia is a common disorder that presents as persistent or recurrent abdominal pain or discomfort in the upper abdomen and originates from organic or functional causes. Heterogeneous disorders, physiopathological, psychosomatic, sociocultural, demographic and genetic components have a great impact ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000179165.33323.18

    authors: de Baptista GA

    更新日期:2005-09-01 00:00:00

  • Nuclear factor kappa B signaling in catabolic disorders.

    abstract::The nuclear factor kappa B family of inducible transcription factors regulates the expression of many genes. Nuclear factor kappa B has been implicated in autoimmune and inflammatory diseases, infection, cell survival, and cell transformation with subsequent promotion of cancer. In this review, we summarize features o...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200205000-00004

    authors: Holmes-McNary M

    更新日期:2002-05-01 00:00:00

  • Non-nutritive sweeteners, energy balance, and glucose homeostasis.

    abstract:PURPOSE OF REVIEW:To review the recent work on potential mechanisms underlying a paradoxical positive association between the consumption of non-nutritive sweeteners (NNS) and weight gain. RECENT FINDINGS:Several potential mechanisms, not mutually exclusive, are hypothesized. First, by dissociating sweetness from calo...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283468e7e

    authors: Pepino MY,Bourne C

    更新日期:2011-07-01 00:00:00

  • Bedside ultrasound measurement of skeletal muscle.

    abstract:PURPOSE OF REVIEW:Skeletal muscle and lean body mass may be vital to prognosis and functional recovery in chronic and acute illness, particularly in conditions in which muscle atrophy is prevalent. Ultrasound provides a precise and expedient method to measure muscle mass and changes in skeletal muscle at the bedside. ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000088

    authors: Mourtzakis M,Wischmeyer P

    更新日期:2014-09-01 00:00:00

  • Clinical efficacy of perioperative nutrition support.

    abstract::Despite a large number of published randomized prospective controlled clinical trials the indications for perioperative parenteral and enteral nutrition support remain controversial. This article reviews the reports of several recently published consensus conference reports and prospective randomized controlled trials...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199801000-00009

    authors: Satyanarayana R,Klein S

    更新日期:1998-01-01 00:00:00

  • Bed rest and myopathies.

    abstract:PURPOSE OF REVIEW:The loss of skeletal muscle with injury or critical illness can be dramatic. This review emphasizes the importance of skeletal muscle as a metabolic reserve. Changes in protein metabolism with bed rest alone and during physiological stress are discussed. Nutritional and hormonal interventions that ame...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000232901.59168.e9

    authors: Ferrando AA,Paddon-Jones D,Wolfe RR

    更新日期:2006-07-01 00:00:00

  • Fighting obesity by targeting factors regulating beige adipocytes.

    abstract:PURPOSE OF REVIEW:The current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity. RECENT FINDINGS:We outline recent studies revealing unrecognized mechanisms controlling beige adipocyte p...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000509

    authors: McQueen AE,Koliwad SK,Wang JC

    更新日期:2018-11-01 00:00:00

  • Maximizing muscle protein anabolism: the role of protein quality.

    abstract:PURPOSE OF REVIEW:Muscle protein synthesis (MPS) and muscle protein breakdown are simultaneous ongoing processes. Here, we examine evidence for how protein quality can affect exercise-induced muscle protein anabolism or protein balance (MPS minus muscle protein breakdown). Evidence is highlighted showing differences in...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32831cef75

    authors: Tang JE,Phillips SM

    更新日期:2009-01-01 00:00:00

  • Plant sterols and blood lipid levels.

    abstract::Plant sterols have recently been recommended by the National Cholesterol Education Panel for use with the more traditional approaches of limiting saturated fat and cholesterol intakes, maintaining a healthy body weight and engaging in regular exercise, as a non-pharmacological approach to reduce low-density lipoprotei...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200203000-00005

    authors: Lichtenstein AH

    更新日期:2002-03-01 00:00:00

  • Vitamin E: absorption, plasma transport and cell uptake.

    abstract:PURPOSE OF REVIEW:Large-scale clinical trials have failed to demonstrate a benefit for vitamin E supplementation in cardiovascular prevention. This contrasts with previous epidemiological studies indicating that individuals with high vitamin E status benefit from protection against chronic illnesses, including cardiova...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200503000-00005

    authors: Hacquebard M,Carpentier YA

    更新日期:2005-03-01 00:00:00

  • Parenteral nutrition in critical illness: total, supplemental or never?

    abstract:PURPOSE OF REVIEW:The current review summarizes recent evolutions in knowledge and discusses the concept of whom and when parenteral nutrition should be considered in critically ill patients as a total form of nutrition, in a supplemental form, or never. RECENT FINDINGS:Recent developments in our understanding of the ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000719

    authors: Ridley EJ

    更新日期:2020-12-10 00:00:00

  • Taurine and skeletal muscle function.

    abstract:PURPOSE OF REVIEW:To discuss the recent work examining the importance of taurine in skeletal muscle and outline the discrepancy that exists between research findings in rodent vs. human skeletal muscle. RECENT FINDINGS:There is clear evidence that a normal taurine level is important for the normal functioning of skele...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000135

    authors: Spriet LL,Whitfield J

    更新日期:2015-01-01 00:00:00

  • Muscular mitochondrial dysfunction and type 2 diabetes mellitus.

    abstract:PURPOSE OF REVIEW:Muscular mitochondrial dysfunction, leading to the accumulation of fat in skeletal muscle, has been proposed to be involved in the development of type 2 diabetes mellitus. Here, we review human studies that investigated various aspects of mitochondrial function in relation to muscular insulin sensitiv...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3282f0eca9

    authors: Schrauwen-Hinderling VB,Roden M,Kooi ME,Hesselink MK,Schrauwen P

    更新日期:2007-11-01 00:00:00

  • Lipid metabolism in critical illness.

    abstract:PURPOSE OF REVIEW:This article describes recent findings regarding lipid metabolism in critical illness as well as in lipid therapy. RECENT FINDINGS:In critical illness, in the presence of a decrease in lipid absorption, adipose tissue lipolysis raises triglyceride levels. High-density lipoprotein and low-density lipo...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000253

    authors: Green P,Theilla M,Singer P

    更新日期:2016-03-01 00:00:00

  • Respiratory function and the obesity paradox.

    abstract:PURPOSE OF REVIEW:Obese individuals have impaired respiratory function relative to their normal-weight counterparts. Despite these negative effects, obesity is paradoxically associated with better survival in individuals with chronic obstructive pulmonary disease (COPD). The purpose of this review is to describe this '...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32833e3453

    authors: Guenette JA,Jensen D,O'Donnell DE

    更新日期:2010-11-01 00:00:00

  • Assessment of status.

    abstract::Laboratory methods for the measurement of micronutrients are usually based upon determinations in the peripheral blood. Most are relatively insensitive, but can screen for impending acute deficiency or toxicity. The metabolic responses to disease, injury and infection may alter the laboratory findings independently of...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199811000-00003

    authors: Fell GS,Talwar D

    更新日期:1998-11-01 00:00:00

  • Prehabilitation: metabolic considerations.

    abstract:PURPOSE OF REVIEW:The major components of ERAS attenuate the inflammatory response and modulate metabolism in direction of sparing body protein and preserving function. However, these perioperative interventions might have limited effectiveness on postoperative outcomes if preoperative risk factors are not addressed an...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000663

    authors: Chabot K,Gillis C,Carli F

    更新日期:2020-07-01 00:00:00

  • Nutrition support in patients with multiple organ failure.

    abstract::The problem with any attempt to feed patients in multiple organ failure is that, because of an ongoing inflammatory process, the conventional techniques of supplying energy and protein do not maintain lean tissue mass. In addition, the conventional markers of nutritional status, both anthropometric (body mass and comp...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199803000-00012

    authors: Campbell IT

    更新日期:1998-03-01 00:00:00

  • Ethical and legal considerations in the provision of nutritional support to the perioperative patient.

    abstract::Despite the extensive current literature on ethics, very few publications have specifically addressed the ethical issues surrounding the provision of nutrition to perioperative patients. Four publications are particularly relevant and highly recommended [1-4]. This review is an attempt to draw attention to those ethic...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200001000-00005

    authors: MacFie J

    更新日期:2000-01-01 00:00:00

  • Improving dietary patterns in patients with nonalcoholic fatty liver disease.

    abstract:PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) is the liver epidemic of our time. Diet strongly influences its development and should be a component of any treatment plan. It is crucial to standardize diet recommendations in an evidence-based manner. RECENT FINDINGS:Calorie restriction per se seems benefic...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283566614

    authors: Carvalhana S,Machado MV,Cortez-Pinto H

    更新日期:2012-09-01 00:00:00

  • Categorizing and qualifying nutritional lipidomic data: defining brutto, medio, genio, and infinio lipid species within macrolipidomics and microlipidomics.

    abstract:PURPOSE OF REVIEW:Lipidomic profiling of biological samples is increasing in nutritional research applications. 'Lipidomic analyses' however can be quite variable in specific methods and the type of information about the specific lipids that is revealed. The lack of defined and simple terminology to describe aspects of...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000495

    authors: Aristizabal Henao JJ,Bradley RM,Duncan RE,Stark KD

    更新日期:2018-09-01 00:00:00

  • Fast digestive proteins and sarcopenia of aging.

    abstract:PURPOSE OF REVIEW:The speed of dietary protein digestion influences postprandial amino acid availability which is crucial for improving altered anabolic response of skeletal muscle one feature of sarcopenia during aging. RECENT FINDINGS:By analogy with carbohydrate and in reference to their absorption rate, dietary pr...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000427

    authors: Boirie Y,Guillet C

    更新日期:2018-01-01 00:00:00

  • The interaction between adipokines, diet and exercise on muscle insulin sensitivity.

    abstract:PURPOSE OF REVIEW:High-fat diets lead to obesity and increase the risk of developing insulin resistance and type 2 diabetes. Adipose tissue and skeletal muscle act as endocrine organs, and produce various cytokines that can potentially alter peripheral insulin sensitivity. The purpose of the present review is to briefl...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e328338236e

    authors: Stefanyk LE,Dyck DJ

    更新日期:2010-05-01 00:00:00