Categorizing and qualifying nutritional lipidomic data: defining brutto, medio, genio, and infinio lipid species within macrolipidomics and microlipidomics.

Abstract:

PURPOSE OF REVIEW:Lipidomic profiling of biological samples is increasing in nutritional research applications. 'Lipidomic analyses' however can be quite variable in specific methods and the type of information about the specific lipids that is revealed. The lack of defined and simple terminology to describe aspects of lipidomics presents a challenge in the use of lipidomics across interdisciplinary research groups. RECENT FINDINGS:We propose the use of macrolipidomics and microlipidomics to define lipidomic strategies based on analytical outcomes. Macrolipidomics involves the global characterization of the most abundant lipids in a system, whereas microlipidomics examines low abundant lipids with potent bioactivity that typically require specialized analyses. We also propose that in addition to the term 'brutto', the terms 'medio, genio, and infinio' be used to indicate when information about the lipid molecule increases from isobars/isomers to regio-isomers with carbon-carbon double bond information. SUMMARY:The use of these terms will help establish a common language around the field of lipidomics and improve communication and uptake in the field of clinical nutrition. Macrolipidomic and microlipidomic terms quickly convey the general purpose of the approach. Brutto, medio, genio, and infino quickly convey the nature of the lipid identification.

authors

Aristizabal Henao JJ,Bradley RM,Duncan RE,Stark KD

doi

10.1097/MCO.0000000000000495

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

352-359

issue

5

eissn

1363-1950

issn

1473-6519

journal_volume

21

pub_type

杂志文章,评审
  • The low FODMAP diet: fundamental therapy in the management of irritable bowel syndrome.

    abstract:PURPOSE OF REVIEW:The low FODMAP diet is now recognized as first-line therapy for treatment of irritable bowel syndrome (IBS) symptoms including abdominal pain, gas, bloating, diarrhea and or constipation. This information must be disseminated for application to clinical practice. RECENT FINDINGS:There are many people...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000398

    authors: Ireton-Jones C

    更新日期:2017-09-01 00:00:00

  • Assessment of muscle mass in critically ill patients: role of the sarcopenia index and images studies.

    abstract:PURPOSE OF REVIEW:Sarcopenia is a progressive generalized decline in skeletal muscle mass, strength, and function. This condition is highly prevalent in critically ill patients and is associated with poor outcomes in the ICU. In this review, we describe the use, evidence, and limitations of the most common validated im...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000673

    authors: Lopez-Ruiz A,Kashani K

    更新日期:2020-09-01 00:00:00

  • Are prospective cohort studies an appropriate tool to answer clinical nutrition questions?

    abstract:PURPOSE OF REVIEW:Randomized controlled trials can be difficult to conduct in critically ill patients and may not always be the most appropriate type of study. Cohort studies can provide valuable information in large complete populations of patients without strict exclusion criteria and without the need for informed co...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32835d803e

    authors: Vincent JL,Preiser JC

    更新日期:2013-03-01 00:00:00

  • Nutrients and dyspepsia: paradigms and reality.

    abstract:PURPOSE OF REVIEW:Dyspepsia is a common disorder that presents as persistent or recurrent abdominal pain or discomfort in the upper abdomen and originates from organic or functional causes. Heterogeneous disorders, physiopathological, psychosomatic, sociocultural, demographic and genetic components have a great impact ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000179165.33323.18

    authors: de Baptista GA

    更新日期:2005-09-01 00:00:00

  • What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?

    abstract::Studies of many different rodent models of muscle wasting have indicated that accelerated proteolysis via the ubiquitin-proteasome pathway is the principal cause of muscle atrophy induced by fasting, cancer cachexia, metabolic acidosis, denervation, disuse, diabetes, sepsis, burns, hyperthyroidism and excess glucocort...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200105000-00003

    authors: Jagoe RT,Goldberg AL

    更新日期:2001-05-01 00:00:00

  • Effects of vitamin K on calcium and bone metabolism.

    abstract::The K vitamins, a group of napthoquinones, are required for the carboxylation of a limited number of proteins including the bone matrix protein osteocalcin. Vitamin K1 (phylloquinone) and vitamin K2 (menaquinones), differ regarding food source (green vegetables and fermented products, respectively), bioavailability an...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200111000-00003

    authors: Zittermann A

    更新日期:2001-11-01 00:00:00

  • The acute and long-term effects of dietary fatty acids on vascular function in health and disease.

    abstract:PURPOSE OF REVIEW:Vascular function is recognized as an early and integrative marker of cardiovascular disease. While there is consistent evidence that the quantity of dietary fat has significant effects on vascular function, the differential effects of individual fatty acids is less clear. This review summarizes recen...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32835c5f29

    authors: Lovegrove JA,Griffin BA

    更新日期:2013-03-01 00:00:00

  • MicroRNA in myogenesis and muscle atrophy.

    abstract:PURPOSE OF REVIEW:To understand the impact of microRNA on myogenesis and muscle wasting in order to provide valuable information for clinical investigation. RECENT FINDINGS:Muscle wasting increases the risk of morbidity/mortality in primary muscle diseases, secondary muscle disorders and elderly population. Muscle mas...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32835f81b9

    authors: Wang XH

    更新日期:2013-05-01 00:00:00

  • Subjective and objective nutritional assessment methods: what do they really assess?

    abstract:PURPOSE OF REVIEW:Objective and subjective methods are used to assess nutritional status. They are used as diagnostic, prognostic and response tools. It is still controversial which of them is more suitable for each situation and what they are really assessing. The most recent findings about these methods will be discu...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3282fba5d7

    authors: Barbosa-Silva MC

    更新日期:2008-05-01 00:00:00

  • Berries, their micronutrients and bone health.

    abstract:PURPOSE OF REVIEW:The design and the development of functional foods is a key issue for bone health and a scientific challenge as well. As most studies have focused on calcium, and have paid less attention to other nutrients, our knowledge of the influence of nutrition on bone health remains limited. It has been well a...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000324

    authors: Davicco MJ,Wittrant Y,Coxam V

    更新日期:2016-11-01 00:00:00

  • Amino acid metabolism in liver disease.

    abstract::The impairment of transsulphuration during methionine degradation in hepatic failure can be counteracted by treatment with S-adenosylmethionine. Regarding the pathogenesis of hepatic encephalopathy, no convincing evidence exists for tryptophan, glutamine or glutamate being involved. Portal-systemic shunting-induced hy...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199901000-00009

    authors: Holm E,Sedlaczek O,Grips E

    更新日期:1999-01-01 00:00:00

  • Dietary nitrate as modulator of physical performance and cardiovascular health.

    abstract:PURPOSE OF REVIEW:Early interventional trials reported improvements in cardiac and exercise outcomes with inorganic nitrate ingestion. The current review aims to provide a brief update of recent evidence regarding ergogenic and cardiovascular effects of dietary nitrate and practical recommendations. RECENT FINDINGS:Re...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000414

    authors: Kerley CP

    更新日期:2017-11-01 00:00:00

  • Selenium and glutamine supplements: where are we heading? A critical care perspective.

    abstract:PURPOSE OF REVIEW:There is considerable interest in glutamine and selenium in critical care as both offer the potential to enhance host defences, through different but complimentary mechanisms and may reduce subsequent infections and mortality. The SIGNET trial (randomized controlled factorial trial) is the largest, cr...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32833617cd

    authors: Andrews PJ

    更新日期:2010-03-01 00:00:00

  • The Geriatric Nutritional Risk Index.

    abstract:PURPOSE OF REVIEW:A new nutrition-related risk assessment tool, the Geriatric Nutritional Risk Index (GNRI), has been recently proposed. The aim of this review is to summarize current evidences on the use of this tool with particular focus on the rationales of its application in elderly healthcare. RECENT FINDINGS:Str...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283186f59

    authors: Cereda E,Pedrolli C

    更新日期:2009-01-01 00:00:00

  • Fiber, prebiotics, and diarrhea: what, why, when and how.

    abstract:PURPOSE OF REVIEW:Dietary fiber and prebiotics have been the focus of research and discussion for decades, but there are still pending concepts and definitions, in particular when addressing their use in the prevention and treatment of diarrhea. The purpose of this review is to present the latest advances in the unders...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000311

    authors: Generoso SV,Lages PC,Correia MITD

    更新日期:2016-09-01 00:00:00

  • Neural systems controlling food intake and energy balance in the modern world.

    abstract:PURPOSE OF REVIEW:Obesity continues to increase around the globe, and creates a major health problem because of its comorbidities such as diabetes and cardiovascular disease. Considering that the major cause of most human obesities is the modern lifestyle in a rapidly changing environment, this suggests that the battle...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200311000-00002

    authors: Berthoud HR

    更新日期:2003-11-01 00:00:00

  • HIV infection, body composition changes and related metabolic complications: contributing factors and evolving management strategies.

    abstract:PURPOSE OF REVIEW:Metabolic toxicities in HIV patients are common and contribute to clinical status and long-term sequelae. Body fat mass alterations, of multifactorial causes, continue to occur, despite use of antiretroviral drugs associated with fewer metabolic side-effects. The role of HIV itself in the development ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283457a8f

    authors: Falutz J

    更新日期:2011-05-01 00:00:00

  • Dietary fibers reduce obesity-related disorders: mechanisms of action.

    abstract:PURPOSE OF REVIEW:Dietary fibers decrease risk of cardiovascular disease and obesity, but the most important mechanisms for fiber's protective properties are debated. The purpose of the review is to summarize the recent human studies that examine mechanisms how dietary fiber decreases risk of obesity-related disorders....

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000696

    authors: Dayib M,Larson J,Slavin J

    更新日期:2020-11-01 00:00:00

  • Nutrition in alcoholic steatohepatitis: more of the same or something new?

    abstract:PURPOSE OF REVIEW:To describe the evidences for and against the different nutritional and nonnutritional therapeutic approaches for severe alcoholic steatohepatitis, based on data from randomized controlled trials, in order to answer the question posed in the title: 'more of the same or something new?'. RECENT FINDING...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32830b5d1e

    authors: Cabré E

    更新日期:2008-09-01 00:00:00

  • Clinical efficacy of perioperative nutrition support.

    abstract::Despite a large number of published randomized prospective controlled clinical trials the indications for perioperative parenteral and enteral nutrition support remain controversial. This article reviews the reports of several recently published consensus conference reports and prospective randomized controlled trials...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199801000-00009

    authors: Satyanarayana R,Klein S

    更新日期:1998-01-01 00:00:00

  • Lipid transporters: membrane transport systems for cholesterol and fatty acids.

    abstract::Lipophilic molecules can passively diffuse across cell membranes, a process that is driven by the concentration gradient, by availability of acceptors to facilitate desorption from the bilayer, and by cellular metabolism. However, evidence has accumulated that supports the existence of specialized, protein-facilitated...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200007000-00003

    authors: Abumrad NA,Sfeir Z,Connelly MA,Coburn C

    更新日期:2000-07-01 00:00:00

  • Prevention of metabolic diseases: fruits (including fruit sugars) vs. vegetables.

    abstract:PURPOSE OF REVIEW:To discuss recent evidence from observational and intervention studies on the relationship between fruit and vegetable (F&V) consumption and metabolic disease. RECENT FINDINGS:Observational studies have consistently demonstrated a modest inverse association between the intake of fruit and leafy green...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000378

    authors: Kuzma JN,Schmidt KA,Kratz M

    更新日期:2017-07-01 00:00:00

  • The role of amino acid profiles in diabetes risk assessment.

    abstract:PURPOSE OF REVIEW:The concentrations of plasma-free amino acids, such as branched-chain amino acids and aromatic amino acids, are associated with visceral obesity, insulin resistance, and the future development of diabetes and cardiovascular diseases. This review discusses recent progress in the early assessment of the...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000305

    authors: Nagao K,Yamakado M

    更新日期:2016-09-01 00:00:00

  • Nutrition support in critically ill septic patients.

    abstract:PURPOSE OF REVIEW:Infection and sepsis remain major challenges in the critically ill. How nutritional therapy can effect real clinical outcomes is not easily apparent from the clinical data. Despite reducing infectious incidence, many studies show little difference in meaningful clinical outcomes. RECENT FINDINGS:Conf...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200303000-00009

    authors: Griffiths RD

    更新日期:2003-03-01 00:00:00

  • Severe acute malnutrition.

    abstract:PURPOSE OF REVIEW:The mortality and morbidity associated with severe acute malnutrition (SAM) remain high. A summary of recent studies that are of interest to clinicians treating children with SAM is provided. RECENT FINDINGS:Three important themes emerged in 2015: the use of anthropometry in the diagnosis of SAM and ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000269

    authors: Nel ED

    更新日期:2016-05-01 00:00:00

  • Nutrient interaction for optimal protein anabolism in resistance exercise.

    abstract:PURPOSE OF REVIEW:The rapid muscle loss that accompanies varying diseased states (cachexia) is due to an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown In the current review, we will discuss and summarize recent evidence in order to provide practical recommendations on exercise and nutrie...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e3283516850

    authors: Breen L,Phillips SM

    更新日期:2012-05-01 00:00:00

  • Dietary supplement intake among the elderly: hazards and benefits.

    abstract:PURPOSE OF REVIEW:A large percentage of older adults do not receive recommended amounts of many nutrients from food alone. Accordingly, the routine use of dietary supplements has become common among older persons. Although supplement use provides potential benefits by increasing nutrient intakes, there are potential dr...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000512

    authors: Walrand S

    更新日期:2018-11-01 00:00:00

  • Preoperative nutritional support at home in head and neck cancer patients: from nutritional benefits to the prevention of the alcohol withdrawal syndrome.

    abstract:PURPOSE OF REVIEW:Preoperative nutritional support in severely malnourished patients decreases complications after major surgery. This review summarizes previous studies on head and neck cancer patients undergoing surgery, and offers recommendations on preoperative nutritional support based on the literature and our ex...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200207000-00013

    authors: Bertrand PC,Piquet MA,Bordier I,Monnier P,Roulet M

    更新日期:2002-07-01 00:00:00

  • Advances in separation science relating to clinical nutrition.

    abstract::Advances in separation science are leading to more sensitive and more specific analysis of the complex mixtures of metabolites, vitamins and nutrients found in biofluids. Recent developments include capillary electrokinetic separations such as capillary electrophoresis, and the linking of separation methods to new for...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199809000-00012

    authors: Perrett D

    更新日期:1998-09-01 00:00:00

  • Some interactions between gastrointestinal function and fluid and electrolyte homeostasis.

    abstract:PURPOSE OF REVIEW:The gastrointestinal tract plays an important role in the maintenance of fluid and electrolyte balance, and its diseases cause disturbances in that balance. Conversely, fluid and electrolyte disorders may disturb gastrointestinal function. The purpose of this review is to highlight some recent literat...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200503000-00015

    authors: Macafee DA,Allison SP,Lobo DN

    更新日期:2005-03-01 00:00:00