Are prospective cohort studies an appropriate tool to answer clinical nutrition questions?

abstract：PURPOSE OF REVIEW:With the increasing incidence of obesity today, related complications such as diabetes, insulin resistance and hepatic steatosis are also becoming major concerns. Since these conditions share a common factor, aberrations in lipid metabolism, understanding the molecular changes that lead to abnormal li...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Sampath H,Ntambi JM

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Sarcopenia is a progressive generalized decline in skeletal muscle mass, strength, and function. This condition is highly prevalent in critically ill patients and is associated with poor outcomes in the ICU. In this review, we describe the use, evidence, and limitations of the most common validated im...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Lopez-Ruiz A,Kashani K

更新日期：2020-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight the recent evicence for optimal protein intake and protein supplementation in older adults. A special focus has been placed on the effects on muscle protein synthesis, strength and overall performance in this population. RECENT FINDINGS:Although for older adults, some additional evidence...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Bauer JM,Diekmann R

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Epigenetics has emerged in recent years as one of the most important biological mechanisms linking exposures across the life course to long-term health. This article reviews recent developments in our understanding of the metabolic and genetic determinants of epigenetic variation in human populations....

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Haggarty P

更新日期：2015-07-01 00:00:00

abstract：PURPOSE OF REVIEW:L-Arginine is the precursor for nitric oxide synthesis. In the brain, nitric oxide acts as a neurotransmitter; in the immune system, nitric oxide acts as a mediator of host defense; in the cardiovascular system, nitric oxide mediates the protective effects of the intact endothelium, acting as an endog...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Böger RH

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The diagnosis of aspiration and its origin in patients on enteral tube feeding is challenging to the physician and provides an important means to prevent pneumonia. This review examines the most recent studies and developments in the field with an approach to the technical aspects of diagnostic method...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Gomes GF,Campos AC,Pisani JC,Macedo ED,Vieira MC

更新日期：2004-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Products of infection, ischemia, and injury stimulate the innate immune system to release proinflammatory cytokines, which act locally to activate specific cellular immune responses and initiate recovery. In pathological cases, however, cytokines are released systemically, resulting in progressive tis...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Friedman SG,Czura CJ,Tracey KJ

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:There is considerable interest in glutamine and selenium in critical care as both offer the potential to enhance host defences, through different but complimentary mechanisms and may reduce subsequent infections and mortality. The SIGNET trial (randomized controlled factorial trial) is the largest, cr...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Andrews PJ

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Metabolic toxicities in HIV patients are common and contribute to clinical status and long-term sequelae. Body fat mass alterations, of multifactorial causes, continue to occur, despite use of antiretroviral drugs associated with fewer metabolic side-effects. The role of HIV itself in the development ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Falutz J

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Large-scale clinical trials have failed to demonstrate a benefit for vitamin E supplementation in cardiovascular prevention. This contrasts with previous epidemiological studies indicating that individuals with high vitamin E status benefit from protection against chronic illnesses, including cardiova...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Hacquebard M,Carpentier YA

更新日期：2005-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiovascular disease is exceptionally prevalent in patients with diabetes mellitus, which is an emerging pandemic. Unfortunately, the pathogenesis of diabetic myocardial disease is still poorly understood. RECENT FINDINGS:Evidence has emerged that perturbed cardiac energy metabolism (excessive depe...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Finck BN

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this study is to highlight recent research findings that advance our understanding of the relation between iron status and neural functioning. RECENT FINDINGS:Recent findings have helped to answer questions pertaining to the interrelationship of iron and neural functioning in three pri...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Murray-Kolb LE

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This article provides an overview of the most recent molecular and clinical outcomes of studies that investigate the effect of weight loss and calorie restriction on carbohydrate metabolism, obtained either by dieting or bariatric surgery. It will focus on aspects of carbohydrate metabolism related to...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Manco M,Mingrone G

更新日期：2005-07-01 00:00:00

abstract：:Critical illness and severe injury induce a number of neuroendocrine changes that initially enhance survival. However, for skeletal muscle, the hormonal environment is such that accelerated catabolism predominates. The prevailing hypercortisolemia is exacerbated by a resistance to or decreased production of anabolic h...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Ferrando AA

更新日期：1999-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Vitamin K is an enzyme cofactor for the carboxylation of vitamin K-dependent proteins. Functions include coagulation and regulation of calcification. Different clinical conditions may alter vitamin K requirements by affecting vitamin K status and vitamin K-dependent proteins carboxylation that are rev...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Harshman SG,Saltzman E,Booth SL

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Skeletal muscle is gaining increased attention as an endocrine organ. Recently, novel myokines and new effects of already established myokines have been identified. The objective of this review is to give an update on the recent advances in the field. RECENT FINDINGS:Several hundred putative myokines...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Karstoft K,Pedersen BK

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Occlusions of central venous catheters in service are frequent, but the random nature of the problem has resulted in a piecemeal approach to solving it. The purpose of this review is to examine what is known from past and recent publications and to recommend strategies for future investigations. RECE...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Hardy G,Ball P

更新日期：2005-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes the relationship between nutritional therapies and the intestinal microbiome of critically ill patients. RECENT FINDINGS:The intestinal microbiome of the critically ill displays a near complete loss of health-promoting microbiota with overgrowth of virulent healthcare-associated...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Krezalek MA,Yeh A,Alverdy JC,Morowitz M

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The main aim of this review is to summarize current knowledge of tumor protein p53-inducible nuclear protein 2 (TP53INP2) function and its role in skeletal muscle proteostasis. RECENT FINDINGS:Autophagy is directly involved in the regulation of skeletal muscle mass. Thus, excessive autophagy is assoc...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Sala D,Zorzano A

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The major components of ERAS attenuate the inflammatory response and modulate metabolism in direction of sparing body protein and preserving function. However, these perioperative interventions might have limited effectiveness on postoperative outcomes if preoperative risk factors are not addressed an...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Chabot K,Gillis C,Carli F

更新日期：2020-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Skeletal muscle metabolic energy, needed to maintain contractile activity, is mainly obtained from glucose and long-chain fatty acids. Recent studies have revealed a remarkable parallel between the regulation of uptake of glucose and fatty acids by muscle, in that each is mediated by sarcolemmal trans...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Glatz JF,Bonen A,Luiken JJ

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an objective and comprehensive review of the recent literature addressing the effects of sex on protein metabolism. We also evaluate whether these differences can be attributed to physiology or methodology. Because of the developmental changes in hormonal milieu and body composition that oc...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Markofski MM,Volpi E

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Postoperative complications in gastrointestinal elective surgery have been described as low. In certain circumstances, however, such as those including high-risk patients, the incidence is higher. In such situations, bacteremia and infectious complications may be caused by translocation of either gast...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Correia MI,Nicoli JR

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article is intended to briefly overview available methodological approaches for the study of regional metabolism in man in vivo, and to summarize recent advances in this field of research. RECENT FINDINGS:Several methods have been developed and currently allow for the qualitative and quantitativ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Magkos F,Sidossis LS

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss recent evidence from observational and intervention studies on the relationship between fruit and vegetable (F&V) consumption and metabolic disease. RECENT FINDINGS:Observational studies have consistently demonstrated a modest inverse association between the intake of fruit and leafy green...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Kuzma JN,Schmidt KA,Kratz M

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this study was to highlight recent evidence on protein requirement and physical activity recommendations in older adults and their interrelationship. RECENT FINDINGS:Higher protein intake in older adults is beneficial for better physical function, reduced fracture risk, healthy ageing and ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Yeung SSY,Chan RSM,Woo J

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Oxidative stress plays a central role in the transition from simple steatosis to nonalcoholic steatohepatitis (NASH). An effective therapeutic strategy is to target reduction in oxidative stress in NASH patients. The aim of this review is to discuss the role of oxidative stress in NASH and biological ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Pacana T,Sanyal AJ

更新日期：2012-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Until relatively recently, the only significant source of lactoferrin in the diet was human lactoferrin, provided in breast milk. Today, however, bovine lactoferrin, isolated by dairy technology, as well as recombinant human lactoferrin are commercially available and can be added to foods and clinical...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Lönnerdal B

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The objective of this review has been to analyse and compare the causes, incidence, severity and treatment of gastrointestinal complications in critically ill children and adults. RECENT FINDINGS:The incidence of gastrointestinal complications in critically ill patients published in the literature is...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： López-Herce J

更新日期：2009-03-01 00:00:00

abstract：:Studies of many different rodent models of muscle wasting have indicated that accelerated proteolysis via the ubiquitin-proteasome pathway is the principal cause of muscle atrophy induced by fasting, cancer cachexia, metabolic acidosis, denervation, disuse, diabetes, sepsis, burns, hyperthyroidism and excess glucocort...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Jagoe RT,Goldberg AL

更新日期：2001-05-01 00:00:00