The role of the peroxisome proliferator-activated receptor alpha pathway in pathological remodeling of the diabetic heart.

abstract：PURPOSE OF REVIEW:Investigations into the regulation of muscle protein synthesis (MPS) are a cornerstone of understanding the control of muscle mass. Rates of MPS are finely tuned according to levels of activity, nutrient availability and health status. For instance, rates of MPS are positively regulated by exercise an...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Phillips BE,Hill DS,Atherton PJ

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular endothelial cells control vascular smooth muscle tone via the release of nitric oxide. Following adverse circulatory conditions, namely trauma and hemorrhage, endothelial cell dysfunction occurs, leading to a decrease in the release of endothelium-derived nitric oxide, which contributes to fu...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Loehe F,Bruns CJ,Nitsch SM,Angele MK

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, the latest evidence on the influence of dietary protein and plasma amino acids in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is discussed. RECENT FINDINGS:Increasing protein consumption during weight loss and maintenance may help reduce liver fat content. Conversely,...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Tricò D,Biancalana E,Solini A

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The data indicating that alcohol is an important factor increasing the risk to develop gastrointestinal cancer are consolidating. The purpose of this review is to summarize current evidence. RECENT FINDINGS:Acetaldehyde is the first metabolite of ethanol metabolism and has direct carcinogenic and mut...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Haas SL,Ye W,Löhr JM

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The review summarizes current knowledge and recent findings about how to practically apply medication in patients with dysphagia and how swallowing function may be positively or negatively affected by drugs. RECENT FINDINGS:Oropharyngeal dysphagia is a major health problem in older persons and was re...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Wirth R,Dziewas R

更新日期：2019-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Skeletal muscle metabolic energy, needed to maintain contractile activity, is mainly obtained from glucose and long-chain fatty acids. Recent studies have revealed a remarkable parallel between the regulation of uptake of glucose and fatty acids by muscle, in that each is mediated by sarcolemmal trans...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Glatz JF,Bonen A,Luiken JJ

更新日期：2002-07-01 00:00:00

abstract：:The nuclear factor kappa B family of inducible transcription factors regulates the expression of many genes. Nuclear factor kappa B has been implicated in autoimmune and inflammatory diseases, infection, cell survival, and cell transformation with subsequent promotion of cancer. In this review, we summarize features o...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Holmes-McNary M

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review methods to measure the content and distribution of body fat or adipose tissue in humans are examined. The review particularly emphasizes methods to characterize regional fat distribution and ectopic fat (fat contained within other tissues) including specific applications and implication...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Goodpaster BH

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Muscle protein synthesis (MPS) and muscle protein breakdown are simultaneous ongoing processes. Here, we examine evidence for how protein quality can affect exercise-induced muscle protein anabolism or protein balance (MPS minus muscle protein breakdown). Evidence is highlighted showing differences in...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Tang JE,Phillips SM

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide clinical investigators with an understanding of factors to consider when wishing to add cytokine and inflammatory marker measurements to their studies. RECENT FINDINGS:Inflammation involves complex and coordinated responses of the immune system to tissue damage. In the absence of tools to ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Zhou X,Fragala MS,McElhaney JE,Kuchel GA

更新日期：2010-09-01 00:00:00

abstract：:Antioxidant nutrients are important for limiting damaging oxidative reactions in cells, which may predispose to the development of major clinical conditions such as heart disease and cancer. There is great interest in the possibility that the antioxidant potential of plant-derived phenolic compounds, such as flavonoid...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Duthie G,Crozier A

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The gastrointestinal tract plays an important role in the maintenance of fluid and electrolyte balance, and its diseases cause disturbances in that balance. Conversely, fluid and electrolyte disorders may disturb gastrointestinal function. The purpose of this review is to highlight some recent literat...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Macafee DA,Allison SP,Lobo DN

更新日期：2005-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Metabolic toxicities in HIV patients are common and contribute to clinical status and long-term sequelae. Body fat mass alterations, of multifactorial causes, continue to occur, despite use of antiretroviral drugs associated with fewer metabolic side-effects. The role of HIV itself in the development ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Falutz J

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To understand the impact of microRNA on myogenesis and muscle wasting in order to provide valuable information for clinical investigation. RECENT FINDINGS:Muscle wasting increases the risk of morbidity/mortality in primary muscle diseases, secondary muscle disorders and elderly population. Muscle mas...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Wang XH

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to highlight recent methodological advances that have helped us to understand the role of intramuscular triglycerides in human health as well as prevention and treatment of disease. In addition to both invasive (muscle biopsy) and noninvasive methods, techniques to assess...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Dubé J,Goodpaster BH

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:A fundamental advance in our understanding of endocrine control of energy balance and body weight came with the discovery of the adipocyte-derived hormone leptin. The leptin pathway appeared to be the long-sought peripheral signal pathway from the adipose tissue to the brain involved in the regulation...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Hukshorn CJ,Saris WH

更新日期：2004-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the recent work on potential mechanisms underlying a paradoxical positive association between the consumption of non-nutritive sweeteners (NNS) and weight gain. RECENT FINDINGS:Several potential mechanisms, not mutually exclusive, are hypothesized. First, by dissociating sweetness from calo...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Pepino MY,Bourne C

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Here, we discuss recent work focused on the role of activating transcription factor 4 (ATF4) in skeletal muscle atrophy. RECENT FINDINGS:Muscle atrophy involves and requires widespread changes in skeletal muscle gene expression; however, the transcriptional regulatory proteins responsible for those c...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Adams CM,Ebert SM,Dyle MC

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) is the liver epidemic of our time. Diet strongly influences its development and should be a component of any treatment plan. It is crucial to standardize diet recommendations in an evidence-based manner. RECENT FINDINGS:Calorie restriction per se seems benefic...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Carvalhana S,Machado MV,Cortez-Pinto H

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Improving our understanding of factors driving fat gain in young children should increase our ability to manage the rising problem of obesity. Accordingly, studies associating timing of adiposity rebound with later obesity are reviewed. RECENT FINDINGS:Investigations in many countries have confirmed ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Taylor RW,Grant AM,Goulding A,Williams SM

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Glutamine and arginine are conditionally essential amino acids because depletion occurs in stressed conditions. Intravenous glutamine supplementation reduces morbidity and mortality in critically ill patients fed parenterally. In surgical patients, arginine-enriched diets have beneficial effects, but ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Coëffier M,Déchelotte P

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The increase in obesity in developed societies drives interest in the interplay of energy intake, metabolic energy expenditure, and body energy stores. A better understanding of energy management in physically active and undernourished humans should help guide strategies to manage obesity safely and e...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Hoyt RW,Friedl KE

更新日期：2006-11-01 00:00:00

abstract：:Advances in separation science are leading to more sensitive and more specific analysis of the complex mixtures of metabolites, vitamins and nutrients found in biofluids. Recent developments include capillary electrokinetic separations such as capillary electrophoresis, and the linking of separation methods to new for...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Perrett D

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Growth hormone is a powerful anabolic hormone necessary for normal growth, but its importance in maintaining the cellular and protein mass in adult life is still unclear. However, it is viewed as a drug capable of combating the tissue loss and some metabolic derangements of aging. Growth hormone exces...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Battezzati A,Bertoli S

更新日期：2005-01-01 00:00:00

abstract：:The liver plays a central role in the control of glucose production. It is also involved in the regulation of insulin secretion and sensitivity through neural pathways. This review will address recent developments in the mechanisms by which hepatic metabolism affects glucose homeostasis in health and disease. Oral glu...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Tappy L,Minehira K

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Intradialytic nutritional support has been used for more than 30 years both in critically ill patients with acute renal failure and during maintenance hemodialysis. Present knowledge allows better estimation of its metabolic and nutritional efficacy, as well its effect on patient outcome. RECENT FIND...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Cano NJ,Leverve XM

更新日期：2008-03-01 00:00:00

abstract：:The intracellular signalling pathways controlling muscle protein synthesis and proteolysis are potential targets for anabolic/anti-catabolic therapy. In this review, we consider both the potentiation of the effect of anabolic hormones and suppression of the catabolic action of cytokines. Potential candidates, in parti...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Palmer RM,Thompson MG

更新日期：1999-05-01 00:00:00

abstract：:Crude measurements of nutritional status, such as body weight, are inadequate to assess the severity and consequence of malnutrition among inflammatory bowel disease patients. Functional deficiency resulting in osteopenia and muscle weakness have been demonstrated in these patients when compared to controls. Manipulat...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Burke A,Lichtenstein GR,Rombeau JL

更新日期：1998-09-01 00:00:00

abstract：:Laboratory methods for the measurement of micronutrients are usually based upon determinations in the peripheral blood. Most are relatively insensitive, but can screen for impending acute deficiency or toxicity. The metabolic responses to disease, injury and infection may alter the laboratory findings independently of...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Fell GS,Talwar D

更新日期：1998-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To analyze current evidence for the posology and pharmacokinetics of selenium supplementation in the critically ill. RECENT FINDINGS:Antioxidants and especially high-dose parenteral selenium may be associated with a significant reduction in mortality among critically ill patients with systemic inflam...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Manzanares W,Hardy G

更新日期：2009-05-01 00:00:00