Abstract:
PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) is the liver epidemic of our time. Diet strongly influences its development and should be a component of any treatment plan. It is crucial to standardize diet recommendations in an evidence-based manner. RECENT FINDINGS:Calorie restriction per se seems beneficial regardless of macronutrients composition. However, fat consumption, mainly cholesterol and saturated fatty acids are particularly steatogenic. There is increasing evidence that fructose, mainly consumed as soft drinks, is highly deleterious to the liver. Controversial results regarding modest alcohol consumption, suggest that although alcohol should not be advised, it should not be strictly forbidden. Recent studies suggest beneficial effects of coffee and tea in NAFLD. SUMMARY:Patients with NAFLD should have an individualized diet recommendation, in order to lose at least 7% of their weight if overweight, reducing caloric intake, mainly at cost of cholesterol and saturated fatty acids. Simple sugars should be avoided, and soft drinks discouraged.
journal_name
Curr Opin Clin Nutr Metab Carejournal_title
Current opinion in clinical nutrition and metabolic careauthors
Carvalhana S,Machado MV,Cortez-Pinto Hdoi
10.1097/MCO.0b013e3283566614subject
Has Abstractpub_date
2012-09-01 00:00:00pages
468-73issue
5eissn
1363-1950issn
1473-6519pii
00075197-201209000-00012journal_volume
15pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:To review the recent work on potential mechanisms underlying a paradoxical positive association between the consumption of non-nutritive sweeteners (NNS) and weight gain. RECENT FINDINGS:Several potential mechanisms, not mutually exclusive, are hypothesized. First, by dissociating sweetness from calo...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e3283468e7e
更新日期:2011-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of the present review is to evaluate the most recent evidence for a role of antioxidant nutrients in the prevention or delay in progression of age-related macular degeneration (AMD), a major cause of visual impairment and blindness in the aging population. RECENT FINDINGS:Recent human stu...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32833308ff
更新日期:2010-01-01 00:00:00
abstract:PURPOSE OF REVIEW:This article is intended to briefly overview available methodological approaches for the study of regional metabolism in man in vivo, and to summarize recent advances in this field of research. RECENT FINDINGS:Several methods have been developed and currently allow for the qualitative and quantitativ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000170756.71114.78
更新日期:2005-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The concentrations of plasma-free amino acids, such as branched-chain amino acids and aromatic amino acids, are associated with visceral obesity, insulin resistance, and the future development of diabetes and cardiovascular diseases. This review discusses recent progress in the early assessment of the...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章
doi:10.1097/MCO.0000000000000305
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The Scored Patient-Generated Subjective Global Assessment (PG-SGA) is used internationally as the reference method for proactive risk assessment (screening), assessment, monitoring and triaging for interventions in patients with cancer. This review aims to explain the rationale behind and data support...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000389
更新日期:2017-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The data indicating that alcohol is an important factor increasing the risk to develop gastrointestinal cancer are consolidating. The purpose of this review is to summarize current evidence. RECENT FINDINGS:Acetaldehyde is the first metabolite of ethanol metabolism and has direct carcinogenic and mut...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e3283566699
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The loss of skeletal muscle with injury or critical illness can be dramatic. This review emphasizes the importance of skeletal muscle as a metabolic reserve. Changes in protein metabolism with bed rest alone and during physiological stress are discussed. Nutritional and hormonal interventions that ame...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000232901.59168.e9
更新日期:2006-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Postoperative complications in gastrointestinal elective surgery have been described as low. In certain circumstances, however, such as those including high-risk patients, the incidence is higher. In such situations, bacteremia and infectious complications may be caused by translocation of either gast...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000241674.55417.c9
更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:There has been growing evidence that lifestyle factors may affect the health and lifespan of an individual by affecting telomere length. The purpose of this review was to highlight the importance of telomeres in human health and aging and to summarize possible lifestyle factors that may affect health ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32834121b1
更新日期:2011-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steato hepatitis have an increasing prevalence among liver diseases. Overweight and obesity are frequently associated conditions in patients with fatty liver. Skeletal muscle mass depletion may also coexist with chronic liver disease even in ob...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000558
更新日期:2019-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Malnutrition and polypharmacy increase with age and polymorbidity and their relationship is based on a number of mechanisms. The occurrence of malnutrition in both in-patients and out-patients and its dependence on polymorbidity and age are well known, but the interrelation of polypharmacy and malnutr...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32835b612e
更新日期:2013-01-01 00:00:00
abstract::Essentially, there have not been any outstanding recent developments in nutritional assessment techniques. However, it would appear that the acceptance that there is no absolute gold standard for nutritional assessment has led to the development of disease specific and clinically relevant subjective global type-assess...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-199805000-00007
更新日期:1998-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Dietary fiber and prebiotics have been the focus of research and discussion for decades, but there are still pending concepts and definitions, in particular when addressing their use in the prevention and treatment of diarrhea. The purpose of this review is to present the latest advances in the unders...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章
doi:10.1097/MCO.0000000000000311
更新日期:2016-09-01 00:00:00
abstract::Crude measurements of nutritional status, such as body weight, are inadequate to assess the severity and consequence of malnutrition among inflammatory bowel disease patients. Functional deficiency resulting in osteopenia and muscle weakness have been demonstrated in these patients when compared to controls. Manipulat...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-199809000-00002
更新日期:1998-09-01 00:00:00
abstract::The majority of the resting energy expenditure can be explained by the energy needs of a few highly metabolic organs, making up a small percentage of the body by weight. The relationship of the specific size, individual metabolism, and proportional contribution to the actual body weight and total energy expenditure fo...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200103000-00011
更新日期:2001-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss transcriptional mechanisms regulating hepatic lipid metabolism. RECENT FINDINGS:Humans who are obese or have diabetes (NIDDM) or metabolic syndrome (MetS) have low blood and tissue levels of C20-22 polyunsaturated fatty acids (PUFAs). Although the impact of low C20-22 PUFAs on disease prog...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328342991c
更新日期:2011-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Investigations into the regulation of muscle protein synthesis (MPS) are a cornerstone of understanding the control of muscle mass. Rates of MPS are finely tuned according to levels of activity, nutrient availability and health status. For instance, rates of MPS are positively regulated by exercise an...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32834d19bc
更新日期:2012-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Cardiovascular disease is exceptionally prevalent in patients with diabetes mellitus, which is an emerging pandemic. Unfortunately, the pathogenesis of diabetic myocardial disease is still poorly understood. RECENT FINDINGS:Evidence has emerged that perturbed cardiac energy metabolism (excessive depe...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000134371.70815.32
更新日期:2004-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent clinical trials have furthered our understanding of the role of probiotic and synbiotic therapy across a variety of diverse diseases including antibiotic-associated diarrhea, Clostridium difficile associated diarrhea, acute pancreatitis, ventilator-associated pneumonia, and sepsis among others....
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32834fcea8
更新日期:2012-03-01 00:00:00
abstract:PURPOSE OF REVIEW:A compromised autophagy is associated with the onset of obesity, type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular and neurodegenerative diseases. Our aim is to review the potential role of ghrelin, a gut hormone involved in energy homeostasis, in the regulation of autophagy. RECENT F...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000390
更新日期:2017-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review describes the relationship between nutritional therapies and the intestinal microbiome of critically ill patients. RECENT FINDINGS:The intestinal microbiome of the critically ill displays a near complete loss of health-promoting microbiota with overgrowth of virulent healthcare-associated...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000348
更新日期:2017-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this study is to highlight recent research findings that advance our understanding of the relation between iron status and neural functioning. RECENT FINDINGS:Recent findings have helped to answer questions pertaining to the interrelationship of iron and neural functioning in three pri...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e3283653ef8
更新日期:2013-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The role of calorie restriction in humans is controversial. Recently, new data in monkeys and humans have provided new insights into the potential role of calorie restriction in longevity. RECENT FINDINGS:A study in rhesus monkeys showed a reduction in aging-associated mortality. A number of controll...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e3283331384
更新日期:2010-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Autophagy is an evolutionarily conserved cellular programme for the turnover of organelles, proteins, and other macromolecules, involving the lysosomal degradation pathway. Emerging evidence suggests that autophagy can play a central role in human metabolism as well as impact diverse cellular processe...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000068
更新日期:2014-07-01 00:00:00
abstract:PURPOSE OF REVIEW:In this review, the latest evidence on the influence of dietary protein and plasma amino acids in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is discussed. RECENT FINDINGS:Increasing protein consumption during weight loss and maintenance may help reduce liver fat content. Conversely,...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章
doi:10.1097/MCO.0000000000000706
更新日期:2021-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Overweight and obesity represent a significant health burden during pregnancy, placing women and their infants at increased risk of adverse health outcomes. Although there is considerable observational literature describing the effect of gestational weight gain in pregnancy, research efforts have focu...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000170
更新日期:2015-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize the literature concerning the relationship between meal patterns and childhood obesity. Literature searches of MEDLINE and the Cochrane Library were performed in October 2009 for studies published in the last 18-24 months. RECENT FINDINGS:Available data indicate that not only meal compos...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32833681a2
更新日期:2010-05-01 00:00:00
abstract:PURPOSE OF REVIEW:There is considerable interest in glutamine and selenium in critical care as both offer the potential to enhance host defences, through different but complimentary mechanisms and may reduce subsequent infections and mortality. The SIGNET trial (randomized controlled factorial trial) is the largest, cr...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32833617cd
更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize recent advances in our understanding of mammalian erythritol metabolism and its use as a predictive biomarker of cardiometabolic disease risk. RECENT FINDINGS:Elevated serum erythritol predicts future central adiposity gain and type 2 diabetes mellitus in healthy adults. Erythritol is a ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章
doi:10.1097/MCO.0000000000000665
更新日期:2020-09-01 00:00:00
abstract::This review examines recent advances in the dietary modulation of gene expression in the gastrointestinal tract. We have chosen to concentrate on individual genes and examine what is known about their regulation, attempting to link different studies together. ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-199907000-00009
更新日期:1999-07-01 00:00:00