Vitamin K: dietary intake and requirements in different clinical conditions.

Abstract:

PURPOSE OF REVIEW:Vitamin K is an enzyme cofactor for the carboxylation of vitamin K-dependent proteins. Functions include coagulation and regulation of calcification. Different clinical conditions may alter vitamin K requirements by affecting vitamin K status and vitamin K-dependent proteins carboxylation that are reviewed here. RECENT FINDINGS:Vitamin K consumption greater than the current usual daily requirement to maintain health is indicated for prevention of vitamin K-deficient bleeding in infants and for rescue of over-anticoagulation in patients on vitamin K-dependent oral anticoagulants. Additional vitamin K intake may be required in malabsorptive conditions such as cystic fibrosis and following bariatric surgery. Carboxylation of vitamin K-dependent proteins occurs in multiple extrahepatic tissues and has been implicated in soft tissue calcification and insulin resistance, although the exact mechanisms have yet to be determined. Contribution of colonic flora to vitamin K requirements remains controversial. SUMMARY:With the increased incidence of vitamin K-deficient bleeding and weight-loss surgical procedures, healthcare professionals need to monitor vitamin K status in certain patient populations. Future research on the roles of vitamin K in extrahepatic tissues as they pertain to chronic disease will provide insight into the therapeutic potential of vitamin K and lead to the development of recommendations for specific clinical populations.

authors

Harshman SG,Saltzman E,Booth SL

doi

10.1097/MCO.0000000000000112

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

531-8

issue

6

eissn

1363-1950

issn

1473-6519

journal_volume

17

pub_type

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