Abstract:
PURPOSE OF REVIEW:Vitamin K is an enzyme cofactor for the carboxylation of vitamin K-dependent proteins. Functions include coagulation and regulation of calcification. Different clinical conditions may alter vitamin K requirements by affecting vitamin K status and vitamin K-dependent proteins carboxylation that are reviewed here. RECENT FINDINGS:Vitamin K consumption greater than the current usual daily requirement to maintain health is indicated for prevention of vitamin K-deficient bleeding in infants and for rescue of over-anticoagulation in patients on vitamin K-dependent oral anticoagulants. Additional vitamin K intake may be required in malabsorptive conditions such as cystic fibrosis and following bariatric surgery. Carboxylation of vitamin K-dependent proteins occurs in multiple extrahepatic tissues and has been implicated in soft tissue calcification and insulin resistance, although the exact mechanisms have yet to be determined. Contribution of colonic flora to vitamin K requirements remains controversial. SUMMARY:With the increased incidence of vitamin K-deficient bleeding and weight-loss surgical procedures, healthcare professionals need to monitor vitamin K status in certain patient populations. Future research on the roles of vitamin K in extrahepatic tissues as they pertain to chronic disease will provide insight into the therapeutic potential of vitamin K and lead to the development of recommendations for specific clinical populations.
journal_name
Curr Opin Clin Nutr Metab Carejournal_title
Current opinion in clinical nutrition and metabolic careauthors
Harshman SG,Saltzman E,Booth SLdoi
10.1097/MCO.0000000000000112subject
Has Abstractpub_date
2014-11-01 00:00:00pages
531-8issue
6eissn
1363-1950issn
1473-6519journal_volume
17pub_type
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32830a49db
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abstract:PURPOSE OF REVIEW:This article reviews recent epidemiologic and intervention studies addressing the impact of hyperglycemia on morbidity and mortality in critically ill patients. It also discusses a growing body of literature examining why elevated blood glucose occurs in hospitalized patients without previously recogn...
journal_title:Current opinion in clinical nutrition and metabolic care
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doi:10.1097/MCO.0b013e3281a3bf0a
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abstract:PURPOSE OF REVIEW:Overweight and obesity represent a significant health burden during pregnancy, placing women and their infants at increased risk of adverse health outcomes. Although there is considerable observational literature describing the effect of gestational weight gain in pregnancy, research efforts have focu...
journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200107000-00005
更新日期:2001-07-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200403000-00013
更新日期:2004-03-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章
doi:10.1097/MCO.0000000000000721
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journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
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更新日期:2006-09-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000362
更新日期:2017-05-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32830b5d1e
更新日期:2008-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Objective and subjective methods are used to assess nutritional status. They are used as diagnostic, prognostic and response tools. It is still controversial which of them is more suitable for each situation and what they are really assessing. The most recent findings about these methods will be discu...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e3282fba5d7
更新日期:2008-05-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000232901.59168.e9
更新日期:2006-07-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200111000-00013
更新日期:2001-11-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200005000-00011
更新日期:2000-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Sarcopenia is a progressive generalized decline in skeletal muscle mass, strength, and function. This condition is highly prevalent in critically ill patients and is associated with poor outcomes in the ICU. In this review, we describe the use, evidence, and limitations of the most common validated im...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章
doi:10.1097/MCO.0000000000000673
更新日期:2020-09-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000111
更新日期:2014-11-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-199907000-00009
更新日期:1999-07-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:2017-11-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328328d13e
更新日期:2009-05-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e3283653ef8
更新日期:2013-11-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200209000-00005
更新日期:2002-09-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/01.mco.0000172585.09762.8e
更新日期:2005-07-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32835b612e
更新日期:2013-01-01 00:00:00
abstract::Critical illness and severe injury induce a number of neuroendocrine changes that initially enhance survival. However, for skeletal muscle, the hormonal environment is such that accelerated catabolism predominates. The prevailing hypercortisolemia is exacerbated by a resistance to or decreased production of anabolic h...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:1999-03-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328011bb1b
更新日期:2007-01-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200203000-00005
更新日期:2002-03-01 00:00:00