Abstract:
PURPOSE OF REVIEW:To characterize methods evaluating and to summarize studies linking various serum 25-hydroxyvitamin D [25(OH)D] concentrations with health status. RECENT FINDINGS:Elucidation of the cell-biologic mechanism of vitamin D action, and numerous clinical trials and observational studies relating vitamin D status to health and disease. CONCLUSION:The distinction between deficiency and insufficiency is not useful or necessary. Serum 25(OH)D values below 120 nmol/l (48 ng/ml) are associated with preventable disease and are therefore indicative of deficiency. The upper limit of the normal range can be set at 225 nmol/l (90 ng/ml), although toxicity is rare below 500 nmol/l (200 ng/ml).
journal_name
Curr Opin Clin Nutr Metab Carejournal_title
Current opinion in clinical nutrition and metabolic careauthors
Heaney RPdoi
10.1097/MCO.0b013e328348ed85subject
Has Abstractpub_date
2011-09-01 00:00:00pages
440-4issue
5eissn
1363-1950issn
1473-6519pii
00075197-201109000-00006journal_volume
14pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:This review describes some of the advances made over the past year in NMR-based metabolomics for the elucidation of known and unknown compounds, including new ways of how to combine this information with high-resolution mass spectrometry. RECENT FINDINGS:A new method allows the back-calculation of ma...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000206
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Trehalose is a disaccharide with manifold industrial, commercial and biomedical uses. In the decade following its initial definition as an autophagy-inducing agent, significant advances have been realized in regard to the applicable clinical and preclinical contexts in which trehalose can be deployed....
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000568
更新日期:2019-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steato hepatitis have an increasing prevalence among liver diseases. Overweight and obesity are frequently associated conditions in patients with fatty liver. Skeletal muscle mass depletion may also coexist with chronic liver disease even in ob...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000558
更新日期:2019-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To highlight recent research that has contributed to an improved understanding of, or resulted in, important changes in the approach to feeding HIV-exposed infants. RECENT FINDINGS:The administration of antiretroviral therapy to a HIV-positive pregnant woman and its continued use during breast-feedin...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328337321a
更新日期:2010-05-01 00:00:00
abstract::The nuclear factor kappa B family of inducible transcription factors regulates the expression of many genes. Nuclear factor kappa B has been implicated in autoimmune and inflammatory diseases, infection, cell survival, and cell transformation with subsequent promotion of cancer. In this review, we summarize features o...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200205000-00004
更新日期:2002-05-01 00:00:00
abstract::Studies of many different rodent models of muscle wasting have indicated that accelerated proteolysis via the ubiquitin-proteasome pathway is the principal cause of muscle atrophy induced by fasting, cancer cachexia, metabolic acidosis, denervation, disuse, diabetes, sepsis, burns, hyperthyroidism and excess glucocort...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200105000-00003
更新日期:2001-05-01 00:00:00
abstract::Acute and chronic diseases are frequently characterized by alterations in energy metabolism that influence nutritional requirements and clinical care. Knowledge of the effect of disease on daily energy expenditure and its components is fundamental to understanding the impact of the disease process on energy balance. T...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200109000-00009
更新日期:2001-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Skeletal muscle and lean body mass may be vital to prognosis and functional recovery in chronic and acute illness, particularly in conditions in which muscle atrophy is prevalent. Ultrasound provides a precise and expedient method to measure muscle mass and changes in skeletal muscle at the bedside. ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000088
更新日期:2014-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Leucine does not only serve as a substrate for protein synthesis but is also recognized as a potent signal nutrient that regulates protein metabolism. Accordingly, leucine supplementation has been suggested to develop muscle mass or prevent protein loss in several conditions characterized by muscle pr...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328336f6b8
更新日期:2010-05-01 00:00:00
abstract::The K vitamins, a group of napthoquinones, are required for the carboxylation of a limited number of proteins including the bone matrix protein osteocalcin. Vitamin K1 (phylloquinone) and vitamin K2 (menaquinones), differ regarding food source (green vegetables and fermented products, respectively), bioavailability an...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200111000-00003
更新日期:2001-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Size at birth is critical in determining life expectancy with both small and large neonates at risk of shortened life spans. This review examines the hormonal and nutritional drivers of intrauterine growth with emphasis on the role of foetal hormones as nutritional signals in utero. RECENT FINDINGS:N...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32835e3643
更新日期:2013-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this overview is to highlight the multiple ways in which oxidative stress could be exacerbating muscle wasting. Understanding these interactions in vivo will assist in identifying opportunities for more targeted therapies to reduce skeletal muscle wasting. RECENT FINDINGS:There are many ex...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328302f3fe
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this study is to highlight recent research findings that advance our understanding of the relation between iron status and neural functioning. RECENT FINDINGS:Recent findings have helped to answer questions pertaining to the interrelationship of iron and neural functioning in three pri...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e3283653ef8
更新日期:2013-11-01 00:00:00
abstract::Crude measurements of nutritional status, such as body weight, are inadequate to assess the severity and consequence of malnutrition among inflammatory bowel disease patients. Functional deficiency resulting in osteopenia and muscle weakness have been demonstrated in these patients when compared to controls. Manipulat...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-199809000-00002
更新日期:1998-09-01 00:00:00
abstract::Milk is the only biomaterial that evolved under the Darwinian selective pressure to nourish growing mammals. The purpose of this article is to review the scientific research that is using new techniques of integrating biological sequence, structure and function, to understand the innovative biology underlying the prod...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200211000-00007
更新日期:2002-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Both dietary and nondietary factors contribute to iron deficiency, the most common nutritional deficiency worldwide. Identifying dietary factors associated with iron deficiency is challenging due to the number of components in food affecting iron absorption. This review describes recent advances in di...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328364f382
更新日期:2013-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss recent evidence from observational and intervention studies on the relationship between fruit and vegetable (F&V) consumption and metabolic disease. RECENT FINDINGS:Observational studies have consistently demonstrated a modest inverse association between the intake of fruit and leafy green...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000378
更新日期:2017-07-01 00:00:00
abstract:PURPOSE OF REVIEW:New evidence has recently supported the notion that brown adipose tissue (BAT) is present in adult humans and can play a prominent role in the regulation of body weight and metabolism. This has renewed the efforts to understand the physiologic mechanisms by which BAT is activated, which in turn could ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000063
更新日期:2014-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Early interventional trials reported improvements in cardiac and exercise outcomes with inorganic nitrate ingestion. The current review aims to provide a brief update of recent evidence regarding ergogenic and cardiovascular effects of dietary nitrate and practical recommendations. RECENT FINDINGS:Re...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000414
更新日期:2017-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The data indicating that alcohol is an important factor increasing the risk to develop gastrointestinal cancer are consolidating. The purpose of this review is to summarize current evidence. RECENT FINDINGS:Acetaldehyde is the first metabolite of ethanol metabolism and has direct carcinogenic and mut...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e3283566699
更新日期:2012-09-01 00:00:00
abstract::Food products have variously been reported as causing, perpetuating or treating irritable bowel syndrome. The evidence for this is reviewed with regard to recent studies investigating symptom reporting, mono- and disaccharide malabsorption and probiotics. The development of objective measures remains an urgent priorit...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200111000-00013
更新日期:2001-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Randomized controlled trials can be difficult to conduct in critically ill patients and may not always be the most appropriate type of study. Cohort studies can provide valuable information in large complete populations of patients without strict exclusion criteria and without the need for informed co...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32835d803e
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews recent epidemiologic and intervention studies addressing the impact of hyperglycemia on morbidity and mortality in critically ill patients. It also discusses a growing body of literature examining why elevated blood glucose occurs in hospitalized patients without previously recogn...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e3281a3bf0a
更新日期:2007-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The rapid muscle loss that accompanies varying diseased states (cachexia) is due to an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown In the current review, we will discuss and summarize recent evidence in order to provide practical recommendations on exercise and nutrie...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e3283516850
更新日期:2012-05-01 00:00:00
abstract::Arginine is a non-essential amino acid in mammals as judged from nitrogen balance study. Citrulline is synthesized from glutamate in the small intestine, whilst kidneys and some other tissues convert citrulline to arginine. Ornithine transcarbamylase and carbamylphosphate synthetase are expressed in liver and small in...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-199807000-00004
更新日期:1998-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide clinical investigators with an understanding of factors to consider when wishing to add cytokine and inflammatory marker measurements to their studies. RECENT FINDINGS:Inflammation involves complex and coordinated responses of the immune system to tissue damage. In the absence of tools to ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32833cf3bc
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The pathogenesis of coronary heart disease is of multifactorial origin. Probably, not all risk factors are satisfactorily understood. This article outlines beneficial vitamin D effects on cardiac function and the vasculature. In addition, human data associating serum vitamin D metabolite levels or ora...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328312c33f
更新日期:2008-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Glutamine and arginine are conditionally essential amino acids because depletion occurs in stressed conditions. Intravenous glutamine supplementation reduces morbidity and mortality in critically ill patients fed parenterally. In surgical patients, arginine-enriched diets have beneficial effects, but ...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328333c27f
更新日期:2010-01-01 00:00:00
abstract::Catabolism of fat-free mass affects both the quality of life and survival of patients. Because of variations in fluid status during acute illness, changes in body weight are difficult to evaluate and interpret during treatment. Nutritional assessment should therefore evaluate fat-free and fat mass changes during metab...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200007000-00013
更新日期:2000-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent literature suggests dietary glutamine supplementation may lower blood glucose in patients with type 1 diabetes (T1D), who have no residual insulin secretion. The mechanisms and potential relevance to the care of T1D remain unclear. RECENT FINDINGS:Glutamine is involved in multiple pathways inc...
journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000530
更新日期:2019-01-01 00:00:00