Abstract:
:Mitochondria play a key role as major regulators of cellular energy homeostasis, but in the context of mitochondrial dysfunction, mitochondria may generate reactive oxidative species and induce cellular apoptosis. Indeed, altered mitochondrial status has been linked to the pathogenesis of several metabolic disorders and specially disorders related to insulin resistance, such as obesity, type 2 diabetes, and other comorbidities comprising the metabolic syndrome. In the present review, we summarize information from various mitochondrial proteomic studies of insulin-sensitive tissues under different metabolic states. To that end, we first focus our attention on the pancreas, as mitochondrial malfunction has been shown to contribute to beta cell failure and impaired insulin release. Furthermore, proteomic studies of mitochondria obtained from liver, muscle, and adipose tissue are summarized, as these tissues constitute the primary insulin target metabolic tissues. Since recent advances in proteomic techniques have exposed the importance of PTMs in the development of metabolic disease, we also present information on specific PTMs that may directly affect mitochondria during the pathogenesis of metabolic disease. Specifically, mitochondrial protein acetylation, phosphorylation, and other PTMs related to oxidative damage, such as nitrosylation and carbonylation, are discussed.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Peinado JR,Diaz-Ruiz A,Frühbeck G,Malagon MMdoi
10.1002/pmic.201300376subject
Has Abstractpub_date
2014-03-01 00:00:00pages
452-66issue
4-5eissn
1615-9853issn
1615-9861journal_volume
14pub_type
杂志文章,评审相关文献
PROTEOMICS文献大全abstract::The gut epithelium formed between an organism and the environment plays an essential role in host-microbe interactions, yet remains one of the least characterized mammalian tissues. Especially the membrane proteins, which are critical to bacterial adhesion, are understudied, because these proteins are low in abundance...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201500024
更新日期:2015-07-01 00:00:00
abstract::Here, we describe the Interactorium, a tool in which a Virtual Cell is used as the context for the seamless visualisation of the yeast protein interaction network, protein complexes and protein 3-D structures. The tool has been designed to display very complex networks of up to 40 000 proteins or 6000 multiprotein com...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200900260
更新日期:2009-12-01 00:00:00
abstract::Seed oil bodies (OBs) are intracellular particles storing lipids as food or biofuel reserves in oleaginous plants. Since Brassica napus OBs could be easily contaminated with protein bodies and/or myrosin cells, they must be purified step by step using floatation technique in order to remove non-specifically trapped pr...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200800449
更新日期:2009-06-01 00:00:00
abstract::Most proteins in all organisms undergo crucial N-terminal modifications involving N-terminal methionine excision, N-alpha-acetylation or N-myristoylation (N-Myr), or S-palmitoylation. We investigated the occurrence of these poorly annotated but essential modifications in proteomes, focusing on eukaryotes. Experimental...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200701191
更新日期:2008-07-01 00:00:00
abstract::Most cancers consist of heterogeneous populations of cells with substantial differences in tumorigenicity. Cells that possess self-renewal and tumor-initiating properties are often called cancer stem cells (CSCs). Since CSCs underlie tumor recurrence and metastasis and are resistant to current anti-cancer therapies, n...
journal_title:Proteomics
pub_type: 杂志文章,评审
doi:10.1002/pmic.201500472
更新日期:2016-12-01 00:00:00
abstract::Data-independent acquisition (DIA) offers several advantages over data-dependent acquisition (DDA) schemes for characterizing complex protein digests analyzed by LC-MS/MS. In contrast to the sequential detection, selection, and analysis of individual ions during DDA, DIA systematically parallelizes the fragmentation o...
journal_title:Proteomics
pub_type: 杂志文章,评审
doi:10.1002/pmic.201400323
更新日期:2015-03-01 00:00:00
abstract::Toxoplasma gondii infects a wide range of hosts worldwide, including humans and domesticated animals causing toxoplasmosis disease. Recently, exosomes, small extracellular vesicles (EV) that contain nucleic acids, proteins, and lipids derived from their original cells were linked with disease protection. The effect of...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201600477
更新日期:2017-08-01 00:00:00
abstract::The array of biomolecules generated by a functioning ecosystem represents both a potential resource for sustainable harvest and a potential indicator of ecosystem health and function. The cupped leaves of the carnivorous pitcher plant, Sarracenia purpurea, harbor a dynamic food web of aquatic invertebrates in a fully ...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201000256
更新日期:2011-06-01 00:00:00
abstract::The tuber of potato (Solanum tuberosum) is commonly used as a model for underground storage organs. In this study, changes in the proteome were followed from tuberization, through tuber development and storage into the sprouting phase. Data interrogation using principal component analysis was able to clearly discrimin...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200600383
更新日期:2006-11-01 00:00:00
abstract::As one of the most important post-translational modifications, the discovery, isolation, and identification of glycoproteins are becoming increasingly important. In this study, a Con A-magnetic particle conjugate-based method was utilized to selectively isolate the glycoproteins and their glycomes from the healthy don...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201200259
更新日期:2013-05-01 00:00:00
abstract::Microglia, as the resident brain immune cells, can exhibit a broad range of activation phenotypes, which have been implicated in a multitude of central nervous system disorders. Current widely studied microglial cell lines are mainly derived from neonatal rodent brain that can limit their relevance to homeostatic func...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201800469
更新日期:2019-06-01 00:00:00
abstract::Brucella melitensis is a facultative intracellular bacterial pathogen that causes brucellosis, a zoonotic disease primarily infecting sheep and goats, characterized by undulant fever, arthritic pain and other neurological disorders in humans. A comprehensive proteomic study of strain 16M was conducted to identify and ...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/1615-9861(200208)2:8<1047::AID-PROT1047>3.
更新日期:2002-08-01 00:00:00
abstract::This study was undertaken to identify growth hormone (GH) responsive proteins and protein expression patterns by short-term recombinant human growth hormone (rhGH) therapy in patients with idiopathic short stature (ISS) using proteomic analysis. Seventeen children (14 males and three females) with ISS were included. T...
journal_title:Proteomics
pub_type: 临床试验,杂志文章
doi:10.1002/pmic.201200131
更新日期:2013-04-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are multipotent cells, which have the capability to differentiate into various mesenchymal tissues such as bone, cartilage, fat, tendon, muscle, and marrow stroma. However, they lose the capability of multi-lineage differentiation after several passages. It is known that basic fibroblast ...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200900165
更新日期:2009-09-01 00:00:00
abstract::Advanced glycation endproduct (AGE) formation is an important mechanism for protein deterioration during diabetic complications and ageing. The effects on AGE formation following dihydroxyacetone (DHA) stress were studied in two model organisms, the yeast Saccharomyces cerevisiae and the nematode Caenorhabditis elegan...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200700165
更新日期:2007-10-01 00:00:00
abstract::Nitric oxide (NO) is a universal signaling molecule and plays a negative role in the metamorphosis of many biphasic organisms. Recently, the NO/cGMP (cyclic guanosine monophosphate) signaling pathway was reported to repress larval settlement in the barnacle Amphibalanus amphitrite. To understand the underlying molecul...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201500112
更新日期:2015-11-01 00:00:00
abstract::Post-translational methylation of the epsilon-amino group of lysine residues regulates a number of protein functions. Calmodulin, a key modulator of intracellular calcium signaling, is methylated on lysine 115 in many species. Although the amino acid sequence of calmodulin is highly conserved in eukaryotes, it has bee...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200700343
更新日期:2007-08-01 00:00:00
abstract::We present here the first proteomics analysis of uveal melanoma (UM) cells. These cells represent a good model for the identification of polypeptide markers, which could be developed as diagnostic tools. UM is the most common primary intraocular tumour in adults. In contrast to other cancers, the survival rate of pati...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200500030
更新日期:2005-12-01 00:00:00
abstract::The ZNF198-fibroblast growth factor receptor-1 (FGFR1) fusion kinase is a constitutively activated tyrosine kinase associated with a specific atypical myeloproliferative disease. The chimeric protein localizes to the cytoplasm, unlike the wild type FGFR1 receptor kinase, and presumably inappropriately phosphorylates s...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200800852
更新日期:2009-08-01 00:00:00
abstract::Metabolite flux to UDP-GlcNAc and Golgi N-glycan biosynthesis regulates surface residency of glycoprotein receptors and transporters, and thus sensitivities of cells to extracellular cues. Salvage of GlcNAc increases UDP-GlcNAc and branching of N-glycans progressively, but displays an optimum for cell proliferation an...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200800208
更新日期:2008-08-01 00:00:00
abstract::Panax ginseng is an important herb that has clear effects on the treatment of diverse diseases. Until now, the natural peptide constitution of this herb remains unclear. Here, we conduct an extensive characterization of Ginseng peptidome using MS-based data mining and sequencing. The screen on the charge states of pre...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201600183
更新日期:2016-11-01 00:00:00
abstract::Integral membrane proteins (IMPs) perform crucial cellular functions and are the primary targets for most pharmaceutical agents. However, the hydrophobic nature of their membrane-embedded domains and their intimate association with lipids make them difficult to handle. Numerous proteomic platforms that include LC sepa...
journal_title:Proteomics
pub_type: 杂志文章,评审
doi:10.1002/pmic.200800210
更新日期:2008-10-01 00:00:00
abstract::We have developed a proteome database (DB), BiomarkerDigger (http://biomarkerdigger.org) that automates data analysis, searching, and metadata-gathering function. The metadata-gathering function searches proteome DBs for protein-protein interaction, Gene Ontology, protein domain, Online Mendelian Inheritance in Man, a...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200800593
更新日期:2009-07-01 00:00:00
abstract::FBXO25 is one of the 68 human F-box proteins that serve as specificity factors for a family of ubiquitin ligases composed of s-phase-kinase associated protein 1, really interesting new gene-box 1, Cullin 1, and F-box protein (SCF1) that are involved in targeting proteins for destruction across the ubiquitin proteasome...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200900419
更新日期:2010-08-01 00:00:00
abstract::In this work, we first immobilized tin(IV) ion on polydopamine-coated magnetic graphene (magG@PDA) to synthesize Sn4+ -immobilized magG@PDA (magG@PDA-Sn4+ ) and successfully applied the material to highly selective enrichment of phosphopeptides. The material gathered the advantages of large surface area of graphene, s...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201600187
更新日期:2016-11-01 00:00:00
abstract::Lipid particles (LP) of all types of cells are a depot of neutral lipids. The present investigation deals with the isolation of LP from the yeast Yarrowia lipolytica and the characterization of their lipid and protein composition. Properties of LP varied depending on the carbon source. LP from glucose-grown cells reve...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200500339
更新日期:2006-03-01 00:00:00
abstract::Most of the energy that is introduced into the oceans by photosynthetic primary producers is in the form of organic matter that then sustains the rest of the food web, from micro to macro-organisms. However, it is the interactions between phototrophs and heterotrophs that are vital to maintaining the nutrient balance ...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201400562
更新日期:2015-10-01 00:00:00
abstract::The main goal of many proteomics experiments is an accurate and rapid quantification and identification of regulated proteins in complex biological samples. The bottleneck in quantitative proteomics remains the availability of efficient software to evaluate and quantify the tremendous amount of mass spectral data acqu...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200900174
更新日期:2010-01-01 00:00:00
abstract::Lumbar spinal stenosis (LSS) is a syndromic degenerative spinal disease and is characterized by spinal canal narrowing with subsequent neural compression causing gait disturbances. Although LSS is a major age-related musculoskeletal disease that causes large decreases in the daily living activities of the elderly, its...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201400442
更新日期:2015-05-01 00:00:00
abstract::Myostatin plays a major role in muscle growth and development and animals with disruption of this gene display marked increases in muscle mass. Little is known about muscle physiological adaptations in relation to this muscle hypertrophy. To provide a more comprehensive view, we analyzed bovine muscles from control, h...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200400925
更新日期:2005-02-01 00:00:00