Abstract:
:Most cancers consist of heterogeneous populations of cells with substantial differences in tumorigenicity. Cells that possess self-renewal and tumor-initiating properties are often called cancer stem cells (CSCs). Since CSCs underlie tumor recurrence and metastasis and are resistant to current anti-cancer therapies, novel therapeutic strategies to efficiently target this subset of cells are needed. Aberrant glycosylation is one of the hallmarks of cancer. Many cancer-associated glycans have been reported to be involved in tumor progression and metastasis, and are used as tumor markers. Over the past several years, we have identified characteristic glycans on CSCs by utilizing recent advances in glycoproteomic technologies. In this review, we would like to summarize a series of our recent studies and discuss possible applications of glycomarkers for CSCs.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Sawanobori A,Moriwaki K,Takamatsu S,Kamada Y,Miyoshi Edoi
10.1002/pmic.201500472subject
Has Abstractpub_date
2016-12-01 00:00:00pages
3073-3080issue
24eissn
1615-9853issn
1615-9861journal_volume
16pub_type
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