Abstract:
:Toxoplasma gondii infects a wide range of hosts worldwide, including humans and domesticated animals causing toxoplasmosis disease. Recently, exosomes, small extracellular vesicles (EV) that contain nucleic acids, proteins, and lipids derived from their original cells were linked with disease protection. The effect of EVs derived from T. gondii on the immune response and its relevance in a physiological context is unknown. Here we disclose the first proteomic profiling of T. gondii EVs compared to EVs isolated from a human foreskin fibroblast infected cell line cultured in a vesicle-free medium. Our results reveal a broad range of canonical exosomes proteins. Data are available via ProteomeXchange with the identifier PXD004895.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Wowk PF,Zardo ML,Miot HT,Goldenberg S,Carvalho PC,Mörking PAdoi
10.1002/pmic.201600477subject
Has Abstractpub_date
2017-08-01 00:00:00issue
15-16eissn
1615-9853issn
1615-9861journal_volume
17pub_type
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