New therapeutic patents used for the treatment of leprosy: a review.

Abstract:

:Leprosy is a granulomatous disease, infectious and transmissible, which affects the skin and peripheral nerves, having Mycobacterium leprae as causative agent. The manifestation of this disease causes cutaneous lesions, peripheral neuropathies and, in more extreme cases, may generate deformities and disabilities in affected individuals. Patents were identified using the descriptor 'leprosy' and code A61K of the international patent classification, which indicates only products that meet human needs. The analysis was made using the WIPO, ESPACENET and USPTO databases, until the month of September 2016. Through this review, we found a variety of in vitro, pre-clinical and clinical studies relating to the treatment of leprosy with different types of compounds and forms of administration. New treatment proposals should include pain reduction capabilities, prevention or limitation of the appearance of cutaneous lesions, as well as prevention of the progression of the disease to more severe stages that may lead to loss of function or potentiate the individual's immune response to the M. leprae bacillus in order to prevent bacterial spread. We concluded that any patents developed with natural products were not found in the treatment of leprosy. All the deposited products were synthetic origin, mostly tested in humans and of varied forms of administration.

journal_name

Epidemiol Infect

authors

Gomes Lima Santos N,Perez Pereira Ramos K,Shanmugam S,Oliveira de Carvalho F,Garcez Barreto Teixeira L,Ramos Silva É,de Vasconcelos Cerqueira-Braz J,Santos Nunes P,Antunes de Souza Araújo A

doi

10.1017/S0950268818002145

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1746-1749

issue

14

eissn

0950-2688

issn

1469-4409

pii

S0950268818002145

journal_volume

146

pub_type

杂志文章,评审
  • Changing epidemiology of cholera due to Vibrio cholerae O1 and O139 Bengal in Dhaka, Bangladesh.

    abstract::At the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B) Dhaka we studied the trends in cholera for the period January 1992 to May 1995. Vibrio cholerae O139 Bengal emerged as a second aetiologic agent of cholera in Dhaka in January 1993. In 1993, the majority of cholera cases was due to V. c...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800052572

    authors: Faruque AS,Fuchs GJ,Albert MJ

    更新日期:1996-06-01 00:00:00

  • Use of antibiotics and risk factors for carriage of Streptococcus pneumoniae: a longitudinal household study in the United Kingdom.

    abstract::This study aimed to identify risk factors and assess the impact of coincidental antibiotic therapy on carriage of Streptococcus pneumoniae. Index children from birth to 3 years and their households were recruited from primary health-care registers in four UK general practices. Nasopharyngeal swabs were taken monthly f...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268808001143

    authors: Pebody RG,Morgan O,Choi Y,George R,Hussain M,Andrews N

    更新日期:2009-04-01 00:00:00

  • Rotavirus detection by dot blot hybridization assay using a non-radioactive synthetic oligodeoxynucleotide probe.

    abstract::A synthetic oligodeoxynucleotide of 40 nucleotides corresponding to nucleotides 33-72 of the gene coding for the viral protein VP7 of rotavirus, was used as a nucleic acid probe to develop a non-radioactive hybridization method for rotavirus detection. The probe was labelled at the 3' end with biotin-7-dATP. The sensi...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800049621

    authors: Fernández J,Sandino A,Yudelevich A,Avendaño LF,Venegas A,Hinrichsen V,Spencer E

    更新日期:1992-02-01 00:00:00

  • High intensities of population movement were associated with high incidence of COVID-19 during the pandemic.

    abstract::Increased population movements and increased mobility made it possible for severe acute respiratory syndrome coronavirus 2, which is mainly spread by respiratory droplets, to spread faster and more easily. This study tracked and analysed the development of the coronavirus 2019 (COVID-19) outbreak in the top 100 cities...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268820001703

    authors: Yang H,Chen D,Jiang Q,Yuan Z

    更新日期:2020-08-03 00:00:00

  • A community outbreak of haemolytic-uraemic syndrome in children occurring in a large area of northern Italy over a period of several months.

    abstract::From March to October 1993, 15 cases of haemolytic-uraemic syndrome (HUS) in children were detected in a large area of northern Italy, where only 8 cases had occurred in the previous 5 years. Analysis of stool and serum specimens obtained from 14 cases showed evidence of Verotoxin-producing Escherichia coli (VTEC) inf...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800051645

    authors: Tozzi AE,Niccolini A,Caprioli A,Luzzi I,Montini G,Zacchello G,Gianviti A,Principato F,Rizzoni G

    更新日期:1994-10-01 00:00:00

  • Diphtheria outbreak in Maranhão, Brazil: microbiological, clinical and epidemiological aspects.

    abstract::We describe microbiological, clinical and epidemiological aspects of a diphtheria outbreak that occurred in Maranhão, Brazil. The majority of the 27 confirmed cases occurred in partially (n = 16) or completely (n = 10) immunized children (n = 26). Clinical signs and characteristic symptoms of diphtheria such as cervic...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268814001241

    authors: Santos LS,Sant'anna LO,Ramos JN,Ladeira EM,Stavracakis-Peixoto R,Borges LL,Santos CS,Napoleão F,Camello TC,Pereira GA,Hirata R,Vieira VV,Cosme LM,Sabbadini PS,Mattos-Guaraldi AL

    更新日期:2015-03-01 00:00:00

  • Molecular typing of Acinetobacter baumannii-Acinetobacter calcoaceticus complex isolates from endemic and epidemic nosocomial infections.

    abstract::Ribotype, biotype and resistance phenotype were used to characterize 37 Acinetobacter baumannii-A. calcoaceticus complex isolates responsible for nosocomial infections in Buenos Aires. Nineteen isolates were recovered from endemic infections at 2 hospitals and 18 represent an intensive care unit outbreak that occurred...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800051979

    authors: Ratto P,Sordelli DO,Abeleira E,Torrero M,Catalano M

    更新日期:1995-02-01 00:00:00

  • Genotyping of hepatitis C virus isolates from Basque Country, Spain.

    abstract::The genotype of HCV was determined in 161 chronic HCV-infected patients. The patients were classified into three groups on the basis of the origin of the HCV infection: 50 patients had a history of intravenous drug use (IVDU) but no HIV infection; 41 patients had received blood transfusions, and 70 patients had no kno...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800059227

    authors: Cilla G,García-Bengoechea M,Perez-Trallero E,Montalvo I,Vicente D,Arenas JI

    更新日期:1996-12-01 00:00:00

  • Association between meteorological factors and reported cases of hand, foot, and mouth disease from 2000 to 2015 in Japan.

    abstract::The purpose of this study was to clarify the association between hand, foot, and mouth disease (HFMD) epidemics and meteorological conditions. We used HFMD surveillance data of all 47 prefectures in Japan from January 2000 to December 2015. Spectral analysis was performed using the maximum entropy method (MEM) for tem...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268817001820

    authors: Sumi A,Toyoda S,Kanou K,Fujimoto T,Mise K,Kohei Y,Koyama A,Kobayashi N

    更新日期:2017-10-01 00:00:00

  • Predicting arboviral disease emergence using Bayesian networks: a case study of dengue virus in Western Australia.

    abstract::A Bayesian Belief Network (BBN) for assessing the potential risk of dengue virus emergence and distribution in Western Australia (WA) is presented and used to identify possible hotspots of dengue outbreaks in summer and winter. The model assesses the probabilities of two kinds of events which must take place before an...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268816002090

    authors: Ho SH,Speldewinde P,Cook A

    更新日期:2017-01-01 00:00:00

  • A school outbreak of pandemic (H1N1) 2009 infection: assessment of secondary household transmission and the protective role of oseltamivir.

    abstract::In mid-June 2009, an outbreak of pandemic (H1N1) 2009 (pH1N1) infection occurred in a secondary school in Hong Kong. We carried out an epidemiological investigation to delineate the characteristics of the outbreak, gauge the extent of secondary household transmission, and assess the protective role of oseltamivir in h...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268810001445

    authors: Leung YH,Li MP,Chuang SK

    更新日期:2011-01-01 00:00:00

  • Applications of machine learning techniques to predict filariasis using socio-economic factors.

    abstract::Filariasis is one of the major public health concerns in India. Approximately 600 million people spread across 250 districts of India are at risk of filariasis. To predict this disease, a pilot scale study was carried out in 30 villages of Karimnagar district of Telangana from 2004 to 2007 to collect epidemiological a...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268819001481

    authors: Kondeti PK,Ravi K,Mutheneni SR,Kadiri MR,Kumaraswamy S,Vadlamani R,Upadhyayula SM

    更新日期:2019-09-02 00:00:00

  • Testing the accuracy ratio of the Spatio-Temporal Epidemiological Modeler (STEM) through Ebola haemorrhagic fever outbreaks.

    abstract::Mathematical modelling is an important tool for understanding the dynamics of the spread of infectious diseases, which could be the result of a natural outbreak or of the intentional release of pathogenic biological agents. Decision makers and policymakers responsible for strategies to contain disease, prevent epidemi...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268815002939

    authors: Baldassi F,D'Amico F,Carestia M,Cenciarelli O,Mancinelli S,Gilardi F,Malizia A,DI Giovanni D,Soave PM,Bellecci C,Gaudio P,Palombi L

    更新日期:2016-05-01 00:00:00

  • The transmission of nosocomial pathogens in an intensive care unit: a space-time clustering and structural equation modelling approach.

    abstract::We investigated the incidence of cases of nosocomial pathogens and risk factors in an intensive treatment unit ward to determine if the number of cases is dependent on location of patients and the colonization/infection history of the ward. A clustering approach method was developed to investigate the patterns of spre...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S095026880999094X

    authors: Rushton SP,Shirley MD,Sheridan EA,Lanyon CV,O'Donnell AG

    更新日期:2010-06-01 00:00:00

  • Is driving a car a risk for Legionnaires' disease?

    abstract::Legionnaires' disease (LD) is a major cause of severe community-acquired pneumonia but the source and mode of transmission are not always apparent, especially in sporadic cases. We hypothesized that LD can be acquired from the air-conditioning systems of motor cars. Swabs were taken from the evaporator compartments of...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268809002568

    authors: Sakamoto R,Ohno A,Nakahara T,Satomura K,Iwanaga S,Kouyama Y,Kura F,Noami M,Kusaka K,Funato T,Takeda M,Matsubayashi K,Okumiya K,Kato N,Yamaguchi K

    更新日期:2009-11-01 00:00:00

  • Full-genome sequence analysis of an uncommon norovirus genotype, GII.21, from South Korea.

    abstract::Noroviruses (NoVs) are major causal agents of acute gastroenteritis in humans. NoV GII.4 is the predominant genotype globally. However, uncommon and minor types of NoVs are consistently detected and some have been shown to dominate over GII.4. Therefore, the prevalence of dominant and uncommon NoVs makes the identific...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268817001273

    authors: Lee JW,Lee SG,Cho HG,Park YJ,Yun JW,Park CJ,Paik SY

    更新日期:2017-08-01 00:00:00

  • Seroprevalence of SARS coronavirus antibody in household contacts.

    abstract::Between March and July 2003, 671 cases of severe acute respiratory syndrome (SARS) were diagnosed in Taiwan with a total of 84 fatalities. After the epidemic, a serological survey was conducted involving the asymptomatic household contacts. Household contacts of 13 index patients were enrolled in the study. Contact hi...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268805004541

    authors: Lee CC,Chen SY,Chang IJ,Tsai PC,Lu TC,Wu PL,Chen WJ,Huang LM,Chang SC

    更新日期:2005-12-01 00:00:00

  • Study of colonization resistance for Enterobacteriaceae in man by experimental contamination and biotyping as well as the possible role of antibodies in the clearance of these bacteria from the intestines.

    abstract::The colonization resistance (CR) of the digestive tract was determined in 10 healthy volunteers by oral contamination with a neomycin resistant Escherichia coli (NR-E. coli) strain and measurement of the faecal concentration of this strain during 14 days after the contamination. This 'gold standard' was compared with ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800049311

    authors: Apperloo-Renkema HZ,van der Waaij D

    更新日期:1991-12-01 00:00:00

  • Contribution of acute-phase reaction proteins to the diagnosis and treatment of 2019 novel coronavirus disease (COVID-19).

    abstract::The emergence of 2019 novel coronavirus disease (COVID-19) is currently a global concern. In this study, our goal was to explore the changing expression levels of acute-phase reaction proteins (APRPs) in the serum of COVID-19 patients and to elucidate the immunological characteristics of COVID-19. In the study design,...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S095026882000165X

    authors: Li L,Chen C

    更新日期:2020-07-27 00:00:00

  • Surveillance for outbreaks of influenza-like illness in the institutionalized elderly.

    abstract::Respiratory outbreaks are common in aged-care facilities (ACFs), are both underreported and frequently identified late, and are often associated with considerable burden of illness and death. There is emerging evidence that active surveillance coupled with early and systematic intervention can reduce this burden. Acti...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268809991440

    authors: Rosewell A,Chiu C,Lindley R,Dwyer DE,Moffatt CR,Shineberg C,Clarke E,Booy R,MacIntyre CR

    更新日期:2010-08-01 00:00:00

  • Legionellosis linked with a hotel car park--how many were infected?

    abstract::An outbreak of legionellosis associated with a hotel in Sydney, Australia, and the subsequent epidemiological and environmental investigations are described. Four cases of Legionnaires' disease were notified to the Public Health Unit. A cross-sectional study of 184 people who attended a seminar at the hotel was carrie...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800052420

    authors: Bell JC,Jorm LR,Williamson M,Shaw NH,Kazandjian DL,Chiew R,Capon AG

    更新日期:1996-04-01 00:00:00

  • Large-scale Lassa fever outbreaks in Nigeria: quantifying the association between disease reproduction number and local rainfall.

    abstract::Lassa fever (LF) is increasingly recognised as an important rodent-borne viral haemorrhagic fever presenting a severe public health threat to sub-Saharan West Africa. In 2017-18, LF caused an unprecedented epidemic in Nigeria and the situation was worsening in 2018-19. This work aims to study the epidemiological featu...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268819002267

    authors: Zhao S,Musa SS,Fu H,He D,Qin J

    更新日期:2020-01-10 00:00:00

  • Estimation of the effect of neutropenia on rates of clinical bacteraemia in HIV-infected patients.

    abstract::A retrospective cohort study was conducted to quantitate the relationship between neutropenia and rates of clinical bacteraemia among adults with HIV infection receiving medical care at one institution between 1991-5. The primary exposure, absolute neutrophil count (ANC), was summarized as mean ANC within a given week...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s095026889700842x

    authors: Caperna J,Barber RE,Toerner JG,Mathews WC

    更新日期:1998-02-01 00:00:00

  • A meta-analysis of the association between obesity and COVID-19.

    abstract::Owing to limited data, we conducted a meta-analysis to re-evaluate the relationship between obesity and coronavirus-2019 (COVID-19). Literature published between 1 January 2020 and 22 August 2020 was comprehensively analysed, and RevMan3.5 was used for data analysis. A total of 50 studies, including data on 18 260 378...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章,meta分析

    doi:10.1017/S0950268820003027

    authors: Yang J,Ma Z,Lei Y

    更新日期:2020-12-22 00:00:00

  • Outbreak of gastroenteritis caused by Yersinia pestis in Afghanistan.

    abstract::Plague, which is most often caused by the bite of Yersinia pestis-infected fleas, is a rapidly progressing, serious disease that can be fatal without prompt antibiotic treatment. In late December 2007, an outbreak of acute gastroenteritis occurred in Nimroz Province of southern Afghanistan. Of the 83 probable cases of...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268810001792

    authors: Leslie T,Whitehouse CA,Yingst S,Baldwin C,Kakar F,Mofleh J,Hami AS,Mustafa L,Omar F,Ayazi E,Rossi C,Noormal B,Ziar N,Kakar R

    更新日期:2011-05-01 00:00:00

  • Age-specific vaccine effectiveness of seasonal 2010/2011 and pandemic influenza A(H1N1) 2009 vaccines in preventing influenza in the United Kingdom.

    abstract::An analysis was undertaken to measure age-specific vaccine effectiveness (VE) of 2010/11 trivalent seasonal influenza vaccine (TIV) and monovalent 2009 pandemic influenza vaccine (PIV) administered in 2009/2010. The test-negative case-control study design was employed based on patients consulting primary care. Overall...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268812001148

    authors: Pebody RG,Andrews N,Fleming DM,McMenamin J,Cottrell S,Smyth B,Durnall H,Robertson C,Carman W,Ellis J,Sebastian-Pillai P,Zambon M,Kearns C,Moore C,Thomas DR,Watson JM

    更新日期:2013-03-01 00:00:00

  • Molecular characterization of capsular polysaccharides and surface protein genes in relation to genetic similarity of group B streptococci isolated from Polish pregnant women.

    abstract::Serotyping, subtyping and genotyping are important tools for epidemiological studies of group B streptococci (GBS). We investigated the genotype distribution of 353 GBS isolates originating from vaginal or rectal carriage to identify capsular serotypes and subtypes based on the surface protein genes of the alpha-like ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268811000616

    authors: Brzychczy-Włoch M,Gosiewski T,Bodaszewska-Lubas M,Adamski P,Heczko PB

    更新日期:2012-02-01 00:00:00

  • Epidemiological investigations on the potential transmissibility of a rare disease: the case of atypical scrapie in Great Britain.

    abstract::Multiple cases of atypical scrapie in the same holding and co-existence with classical scrapie have been reported in Great Britain. A two-stage simulation tool was developed by combining a sampling algorithm and a hierarchical Bayesian model to simulate the number of positive cases of atypical scrapie from: (i) random...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268816000303

    authors: Ortiz-Peláez A,Arnold ME,Vidal-Diez A

    更新日期:2016-07-01 00:00:00

  • The role of temperature in reported chickenpox cases from 2000 to 2011 in Japan.

    abstract::Annual periodicities of reported chickenpox cases have been observed in several countries. Of these, Japan has reported a two-peaked, bimodal annual cycle of reported chickenpox cases. This study investigated the possible underlying association of the bimodal cycle observed in the surveillance data of reported chicken...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S095026881400363X

    authors: Harigane K,Sumi A,Mise K,Kobayashi N

    更新日期:2015-09-01 00:00:00

  • Faecal contamination of water and fingertip-rinses as a method for evaluating the effect of low-cost water supply and sanitation activities on faeco-oral disease transmission. I. A case study in rural north-east Thailand.

    abstract::Most villagers in north-east Thailand carry water to their homes and store it in separate containers depending on its subsequent use. In one village, information on water use was collated with the bacteriological quality of stored water, water sources and fingertip-rinses. Stored water quality was a function of water-...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800047956

    authors: Pinfold JV

    更新日期:1990-10-01 00:00:00