Abstract:
:We describe microbiological, clinical and epidemiological aspects of a diphtheria outbreak that occurred in Maranhão, Brazil. The majority of the 27 confirmed cases occurred in partially (n = 16) or completely (n = 10) immunized children (n = 26). Clinical signs and characteristic symptoms of diphtheria such as cervical lymphadenopathy and pseudomembrane formation were absent in 48% and 7% of the cases, respectively. Complications such as paralysis of lower limbs were observed. Three cases resulted in death, two of them in completely immunized children. Microbiological analysis identified the isolates as Corynebacterium diphtheriae biovar intermedius with a predominant PFGE type. Most of them were toxigenic and some showed a decrease in penicillin G susceptibility. In conclusion, diphtheria remains endemic in Brazil. Health professionals need to be aware of the possibility of atypical cases of C. diphtheriae infection, including pharyngitis without pseudomembrane formation.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Santos LS,Sant'anna LO,Ramos JN,Ladeira EM,Stavracakis-Peixoto R,Borges LL,Santos CS,Napoleão F,Camello TC,Pereira GA,Hirata R,Vieira VV,Cosme LM,Sabbadini PS,Mattos-Guaraldi ALdoi
10.1017/S0950268814001241subject
Has Abstractpub_date
2015-03-01 00:00:00pages
791-8issue
4eissn
0950-2688issn
1469-4409pii
S0950268814001241journal_volume
143pub_type
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