Abstract:
:An analysis was undertaken to measure age-specific vaccine effectiveness (VE) of 2010/11 trivalent seasonal influenza vaccine (TIV) and monovalent 2009 pandemic influenza vaccine (PIV) administered in 2009/2010. The test-negative case-control study design was employed based on patients consulting primary care. Overall TIV effectiveness, adjusted for age and month, against confirmed influenza A(H1N1)pdm 2009 infection was 56% (95% CI 42-66); age-specific adjusted VE was 87% (95% CI 45-97) in <5-year-olds and 84% (95% CI 27-97) in 5- to 14-year-olds. Adjusted VE for PIV was only 28% (95% CI -6 to 51) overall and 72% (95% CI 15-91) in <5-year-olds. For confirmed influenza B infection, TIV effectiveness was 57% (95% CI 42-68) and in 5- to 14-year-olds 75% (95% CI 32-91). TIV provided moderate protection against the main circulating strains in 2010/2011, with higher protection in children. PIV administered during the previous season provided residual protection after 1 year, particularly in the <5 years age group.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Pebody RG,Andrews N,Fleming DM,McMenamin J,Cottrell S,Smyth B,Durnall H,Robertson C,Carman W,Ellis J,Sebastian-Pillai P,Zambon M,Kearns C,Moore C,Thomas DR,Watson JMdoi
10.1017/S0950268812001148subject
Has Abstractpub_date
2013-03-01 00:00:00pages
620-30issue
3eissn
0950-2688issn
1469-4409pii
S0950268812001148journal_volume
141pub_type
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