Clinical and imaging progression over 10 years in a patient with primary progressive apraxia of speech and autopsy-confirmed corticobasal degeneration.

Abstract:

:Primary progressive apraxia of speech (PPAOS) is a neurodegenerative disorder in which AOS is the sole presenting complaint. We report clinical and neuroimaging data spanning 10 years from disease onset-to-death in a 49 year-old male PPAOS patient, DY, who died with corticobasal degeneration. He presented with AOS with normal neuroimaging. Abnormalities in the caudate nucleus, supplementary motor area, cingulate, insula, and Broca's area were observed after five years, with involvement of motor cortex and development of agrammatism, Parkinsonism, and dysarthria three years later. Cognitive impairment and temporoparietal atrophy were late features. This data provides important insight into disease progression of corticobasal degeneration when presenting as PPAOS.

journal_name

Neurocase

journal_title

Neurocase

authors

Tetzloff KA,Duffy JR,Strand EA,Machulda MM,Boland SM,Utianski RL,Botha H,Senjem ML,Schwarz CG,Josephs KA,Whitwell JL

doi

10.1080/13554794.2018.1477963

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

111-120

issue

2

eissn

1355-4794

issn

1465-3656

journal_volume

24

pub_type

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