Abstract:
:A 57-year-old man suffered severe amnesia and disorientation, accompanied by content-specific confabulation, due to an alcoholic Wernicke-Korsakoff syndrome. For months, he was deeply concerned about a single obligation that he thought he had to respond to, but which he had already assumed 20 years previously. This monothematic, prospective confabulation was associated with failures of reality filtering as previously documented in behaviorally spontaneous confabulation and disorientation: the patient failed to suppress the interference of currently irrelevant memories and to abandon anticipations that were no longer valid (impaired extinction capacity). Magnetic resonance imaging showed damage to the mamillary bodies and the dorsomedial thalamic nucleus. Positron emission tomography (FDG-PET) showed extended orbitofrontal hypometabolism. We suggest that isolated prospective confabulation shares the core feature (acts and thoughts based on currently irrelevant memory), mechanism (failure of reality filtering), and anatomical basis (orbitofrontal dysfunction) with behaviorally spontaneous confabulations.
journal_name
Neurocasejournal_title
Neurocaseauthors
Schnider A,Nahum L,Pignat JM,Leemann B,Lövblad KO,Wissmeyer M,Ptak Rdoi
10.1080/13554794.2011.654221subject
Has Abstractpub_date
2013-01-01 00:00:00pages
90-104issue
1eissn
1355-4794issn
1465-3656journal_volume
19pub_type
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