Effect of propranolol on verbal problem solving in autism spectrum disorder.

Abstract:

:The noradrenergic system modulates performance on tasks dependent on semantic and associative network flexibility (NF) in individuals without neurodevelopmental diagnoses in experiments using a beta-adrenergic antagonist, propranolol. Some studies suggest drugs decreasing noradrenergic activity are beneficial in ASD. In individuals without neurodevelopmental diagnoses, propranolol is beneficial only for difficult NF-dependent problems. However, in populations with altered noradrenergic regulation, propranolol also benefits performance for simple problems. Due to decreased flexibility of access to networks in ASD, we wished to examine the effect of propranolol on NF in ASD. ASD subjects benefited from propranolol on simple anagrams, whereas control subjects were impaired by propranolol. Further study will be necessary to confirm this finding in a larger sample and to compare clinical response with cognitive response to propranolol.

journal_name

Neurocase

journal_title

Neurocase

authors

Beversdorf DQ,Carpenter AL,Miller RF,Cios JS,Hillier A

doi

10.1080/13554790802368661

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

378-83

issue

4

eissn

1355-4794

issn

1465-3656

pii

902118822

journal_volume

14

pub_type

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