Abstract:
:The noradrenergic system modulates performance on tasks dependent on semantic and associative network flexibility (NF) in individuals without neurodevelopmental diagnoses in experiments using a beta-adrenergic antagonist, propranolol. Some studies suggest drugs decreasing noradrenergic activity are beneficial in ASD. In individuals without neurodevelopmental diagnoses, propranolol is beneficial only for difficult NF-dependent problems. However, in populations with altered noradrenergic regulation, propranolol also benefits performance for simple problems. Due to decreased flexibility of access to networks in ASD, we wished to examine the effect of propranolol on NF in ASD. ASD subjects benefited from propranolol on simple anagrams, whereas control subjects were impaired by propranolol. Further study will be necessary to confirm this finding in a larger sample and to compare clinical response with cognitive response to propranolol.
journal_name
Neurocasejournal_title
Neurocaseauthors
Beversdorf DQ,Carpenter AL,Miller RF,Cios JS,Hillier Adoi
10.1080/13554790802368661subject
Has Abstractpub_date
2008-01-01 00:00:00pages
378-83issue
4eissn
1355-4794issn
1465-3656pii
902118822journal_volume
14pub_type
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