FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment.

Abstract:

:The accurate prediction, at a pre-dementia stage of Alzheimer's disease (AD), of the subsequent clinical evolution of patients would be a major breakthrough from both therapeutic and research standpoints. Amnestic mild cognitive impairment (MCI) is presently the most common reference to address the pre-dementia stage of AD. However, previous longitudinal studies on patients with MCI assessing neuropsychological and PET markers of future conversion to AD are sparse and yield discrepant findings, while a comprehensive comparison of the relative accuracy of these two categories of measure is still lacking. In the present study, we assessed the global cognitive decline as measured by the Mattis scale in 18 patients with amnestic MCI over an 18-month follow-up period, studying which subtest of this scale showed significant deterioration over time. Using baseline measurements from neuropsychological evaluation of memory and PET, we then assessed significant markers of global cognitive change, that is, percent annual change in the Mattis scale total score, and searched for the best predictor of this global cognitive decline. Altogether, our results revealed significant decline over the 18-month follow-up period in the total score and the verbal initiation and memory-recall subscores of the Mattis scale. The percent annual change in the total Mattis score significantly correlated with age and baseline performances in delayed episodic memory recall as well as semantic autobiographical and category word fluencies. Regarding functional imaging, significant correlations were also found with baseline PET values in the right temporo-parietal and medial frontal areas. Age and right temporo-parietal PET values were the most significant predictors of subsequent global cognitive decline, and the only ones to survive stepwise regression analyses. Our findings are consistent with previous works showing predominant delayed recall and semantic memory impairment at a pre-dementia stage of AD, as well as early metabolic defects in the temporo-parietal associative cortex. However, they suggest that only the latter predictor is specifically and accurately associated with subsequent cognitive decline in patients with MCI within 18 months of first assessment.

journal_name

Neurocase

journal_title

Neurocase

authors

Chételat G,Eustache F,Viader F,De La Sayette V,Pélerin A,Mézenge F,Hannequin D,Dupuy B,Baron JC,Desgranges B

doi

10.1080/13554790490896938

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

14-25

issue

1

eissn

1355-4794

issn

1465-3656

pii

NN64281XH520736R

journal_volume

11

pub_type

杂志文章
  • Pure alexia with intact perception of complex visual stimuli: a case study.

    abstract::After a stroke involving the left occipitotemporal cortex our patient shows a word-length effect and has problems to identify letters or numbers in strings of symbols. But he is normal in identifying isolated letters and in non-verbally categorizing even complex images such as faces or natural scenes. His cortical les...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2019.1634739

    authors: Spang KM,Grimsen C,Brunner F,Fahle MW

    更新日期:2019-10-01 00:00:00

  • Asymptomatic motor cortex displacement due to a giant arachnoid cyst.

    abstract::Cerebral lesions are held to induce plastic changes of the brain. Less well established, however, is how much space-occupying brain lesions may only displace functional representations. In a 66-year-old man we show, by means of functional magnetic resonance imaging and transcranial magnetic stimulation, a profound dis...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554790701849910

    authors: Nickel J,Jörgens S,Bussfeld P,Seitz RJ

    更新日期:2007-10-01 00:00:00

  • Complete, bilateral hippocampal ischemia: a case series.

    abstract::Acute and complete ischemia of the hippocampi represents a rare cause of amnesia. This paper describes the features of four such cases presenting to a single tertiary care center over a 3-year period. Interestingly, in three instances, toxicology screening was positive for opioids at the time of presentation, while in...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2016.1213299

    authors: Small JE,Butler PM,Zabar Y,Barash JA

    更新日期:2016-10-01 00:00:00

  • Dementia with Lewy bodies presenting as Logopenic variant primary progressive Aphasia.

    abstract::We report a patient presenting with clinical features of logopenic variant primary progressive aphasia (lvPPA) who was later diagnosed with probable dementia with Lewy bodies. LvPPA is a neurodegenerative disease that is characterized by anomia, word-finding difficulty, impaired comprehension, and phonological errors....

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2020.1795204

    authors: Boes S,Botha H,Machulda M,Lowe V,Graff-Radford J,Whitwell JL,Utianski RL,Duffy JR,Josephs KA

    更新日期:2020-10-01 00:00:00

  • Synaesthesia for finger counting and dice patterns: a case of higher synaesthesia?

    abstract::Synaesthesia is often triggered by numbers, although it is conceivable that different aspects of numerical representation are responsible for different variants of synaesthesia. For individuals with "higher synaesthesia" it is assumed that number meaning (or numerosity) is responsible for the elicitation of synaesthet...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554790701300518

    authors: Ward J,Sagiv N

    更新日期:2007-04-01 00:00:00

  • Atypical association of semantic dementia, corticobasal syndrome, and 4R tauopathy.

    abstract::A 57-year-old male with no family history was diagnosed with semantic dementia. He also showed some unusual cognitive features such as episodic memory and executive dysfunctions, spatial disorientation, and dyscalculia. Rapidly progressive cognitive and physical decline occurred. About 1.5 years later, he developed cl...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2013.841953

    authors: Clerc MT,Deprez M,Leuba G,Lhermitte B,Lopez U,von Gunten A

    更新日期:2015-02-01 00:00:00

  • Degree of abnormality is associated with rate of change in measures of beta-amyloid, glucose metabolism and cognition in an autopsy-verified Alzheimer's disease case.

    abstract::The degree of abnormality and rate of change in cognitive functions, positron emission tomography Pittsburg compound B (PET PIB), and fluorodeoxyglucose (FDG) measures were studied for 8 years in an autopsy-confirmed Alzheimer's disease (AD) patient, who died 61 years old (Mini-Mental State Examination (MMSE) score 7)...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2014.979835

    authors: Almkvist O,Kadir A,Nordberg A

    更新日期:2015-01-01 00:00:00

  • The role of the thalamus in recovery from tactile extinction and crossed tactile extinction.

    abstract::A 68-year-old man had a cerebral infarction affecting the right parietal lobe, right insula, and the left prefrontal region. On admission, left hand tactile extinction was noted when the hands were placed both in anatomical and crossed positions, but was noted only in crossed positions from day 20 and later. Five mont...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2012.732082

    authors: Asada T,Takeda K,Okiyama R,Isozaki E,Fukuyama H

    更新日期:2014-01-01 00:00:00

  • Isolated, relative aproverbia without focal lesion.

    abstract::We have seen a patient with a profound, isolated, and quite selective deficit in proverb interpretation-aproverbia. The patient presented to us after an anoxic brain injury with aproverbia. Interestingly, the aproverbia appeared to be premorbid to the presenting event. Furthermore, the patient had no brain lesion that...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2016.1139728

    authors: Brown C,Smith-Benjamin S,Patira R,Altschuler EL

    更新日期:2016-06-01 00:00:00

  • Cognitive neuropsychological analysis of differential reading and spelling disorder mechanisms in a patient with aphasia.

    abstract::The purpose of this study was to determine if differential reading and spelling mechanisms were involved in a Japanese patient with aphasia. In our case, the patient scored low on all of the administered reading tasks, suggesting that both the reading lexical and non-lexical routes were impaired. In contrast, his writ...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2015.1137950

    authors: Hashimoto K,Uno A

    更新日期:2016-06-01 00:00:00

  • Anxiety as the only manifestation of focal non-convulsive status epilepticus: case report and review of the literature.

    abstract::Psychiatric disorders represent common comorbidities in epileptic patients. Sometimes anxiety is part of the ictal semiology, especially during seizures arising from/involving frontal or temporal lobes. We describe a patient with focal epilepsy and recurrent hyperkinetic seizures who also presented prolonged episodes ...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2020.1741647

    authors: Albini M,Morano A,Fattouch J,Fanella M,Avorio F,Basili LM,Cerulli Irelli E,Manfredi M,Giallonardo AT,Di Bonaventura C

    更新日期:2020-04-01 00:00:00

  • How loss of meaning with preservation of phonological word form affects immediate serial recall performance: a linguistic account.

    abstract::We present HP, a patient who following the occurrence of herpes simplex encephalitis, lost the ability to understand a subset of words while others remained preserved. Of particular interest is the fact that the meaningless items retained their lexical status. HP's immediate serial recall of meaningless words was thus...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1076/neur.8.3.255.16196

    authors: Caza N,Belleville S,Gilbert B

    更新日期:2002-01-01 00:00:00

  • Acute and long-term VNS effects on pain perception in a case of treatment-resistant depression.

    abstract::Vagus Nerve Stimulation (VNS) is approved by the FDA for treatment of both epilepsy and depression. Recent work has shown that VNS acutely affects pain perception in humans, actually increasing pain sensitivity momentarily while the device is firing. It is unclear how this acutely increased sensitivity might change ov...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554790600788094

    authors: Borckardt JJ,Anderson B,Andrew Kozel F,Nahas Z,Richard Smith A,Jackson Thomas K,Kose S,George MS

    更新日期:2006-08-01 00:00:00

  • Clinical and imaging progression over 10 years in a patient with primary progressive apraxia of speech and autopsy-confirmed corticobasal degeneration.

    abstract::Primary progressive apraxia of speech (PPAOS) is a neurodegenerative disorder in which AOS is the sole presenting complaint. We report clinical and neuroimaging data spanning 10 years from disease onset-to-death in a 49 year-old male PPAOS patient, DY, who died with corticobasal degeneration. He presented with AOS wit...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2018.1477963

    authors: Tetzloff KA,Duffy JR,Strand EA,Machulda MM,Boland SM,Utianski RL,Botha H,Senjem ML,Schwarz CG,Josephs KA,Whitwell JL

    更新日期:2018-04-01 00:00:00

  • Measuring the hemodynamic response in chronic hypoperfusion.

    abstract::Although structural brain scans help assess brain injury in stroke, they cannot identify regions that are functionally disabled due to disrupted perfusion. Perfusion and functional MRI have the potential for determining the functional consequences of stroke. Here we examine the effectiveness of functional MRI to measu...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554790600598816

    authors: Fridriksson J,Rorden C,Morgan PS,Morrow KL,Baylis GC

    更新日期:2006-06-01 00:00:00

  • Improved verbal learning in the semantic variant of primary progressive aphasia when using semantic cues.

    abstract::The semantic variant of primary progressive aphasia (PPA-S) is characterized by impairments in confrontation naming and single word comprehension. Although episodic memory may be relatively spared, there can be impairment in verbal learning tasks. We report a patient with PPA-S and impaired verbal learning who was tes...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2014.894081

    authors: Milano NJ,Williamson JB,Heilman KM

    更新日期:2015-01-01 00:00:00

  • Left hemispatial neglect with a splenial lesion.

    abstract::With injury of the anterior two-thirds of the corpus callosum, each hemisphere's attentional bias to contralateral hemispace becomes manifest with each hand deviating ipsilaterally during line bisection tasks. Patients with infarctions in the right posterior cerebral artery distribution with occipital and splenial dam...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2018.1539501

    authors: Kesayan T,Gasoyan H,Heilman KM

    更新日期:2018-08-01 00:00:00

  • Differential diagnosis between schizophrenia and autism in adulthood: a case report.

    abstract::The clinical distinction between autism spectrum disorders (ASD), also called pervasive developmental disorders (PDD), and schizophrenia is often difficult to make. Here we describe a case of an adult patient presenting with a diagnosis of schizophrenia based on a history of functional deterioration and presumed perse...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2012.713492

    authors: Crivelli B,Rocca P

    更新日期:2013-01-01 00:00:00

  • A case of prosopometamorphopsia caused by infarction of the splenium of the corpus callosum and major forceps.

    abstract::An adult female complained of enlargement of right eyes in other people. Diffusion-weighted imaging detected an abnormal high-intensity area in the region from the splenium of the corpus callosum to the major forceps on the right side. The patient reported that right eyes appeared larger in size, which suggested proso...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2020.1797819

    authors: Ogawa K,Akimoto T,Takahashi K,Hara M,Morita A,Kamei S,Nakajima H,Fujishiro M,Suzuki Y,Soma M,Shikata E,Futamura A,Kawamura M

    更新日期:2020-10-01 00:00:00

  • From progressive nonfluent aphasia to corticobasal syndrome: a case report of corticobasal degeneration.

    abstract::In a previous report, we presented longitudinal clinical, cognitive and anatomical data of a right-handed woman, whose clinical picture evolved from progressive nonfluent aphasia with apraxia of speech to corticobasal syndrome (CBS) in the last stage of the disease. The patient died at age 57 and pathological examinat...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554790600977218

    authors: Sánchez-Valle R,Forman MS,Miller BL,Gorno-Tempini ML

    更新日期:2006-12-01 00:00:00

  • Effect of propranolol on naming in chronic Broca's aphasia with anomia.

    abstract::Previous research suggests that the noradrenergic system modulates flexibility of access to the lexical-semantic network, with propranolol benefiting normal subjects in lexical-semantic problem solving tasks. Patients with Broca's aphasia with anomia have impaired ability to access appropriate verbal output for a give...

    journal_title:Neurocase

    pub_type: 临床试验,杂志文章

    doi:10.1080/13554790701595471

    authors: Beversdorf DQ,Sharma UK,Phillips NN,Notestine MA,Slivka AP,Friedman NM,Schneider SL,Nagaraja HN,Hillier A

    更新日期:2007-08-01 00:00:00

  • Distinguishing logopenic from semantic & nonfluent variant primary progressive aphasia: Patterns of linguistic and behavioral correlations.

    abstract::While language characteristics of logopenic variant primary progressive aphasia (lvPPA) are well-defined, behavioral characteristics are less understood. We investigated correlations between language and behavioral scores across three variants of primary progressive aphasia (PPA) and found language performance and beh...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2019.1625929

    authors: Keator LM,Wright AE,Saxena S,Kim K,Demsky C,Sebastian R,Sheppard SM,Breining B,Hillis AE,Tippett DC

    更新日期:2019-01-01 00:00:00

  • Preserved cognition and functional independence after a large right posterior cerebral artery infarct: longitudinal clinical and neuropathological findings.

    abstract::BVR was 77 years old when he sustained a large posterior cerebral artery territory infarct. Medical, cognitive and functional data collected on four occasions over 10 years initially revealed circumscribed neurological signs, no functional or cognitive deficits. BVR became significantly impaired only after two other s...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554790500502918

    authors: Piguet O,Bennett HP,Waite LM,Kril JJ,Creasey H,Anthony Broe G,Halliday GM

    更新日期:2006-04-01 00:00:00

  • Visual and tactile size distortion in a patient with right neglect.

    abstract::One typical feature of the neglect syndrome in patients with right hemisphere damage is that they bisect horizontal lines to the right of centre. It has been argued that to a large extent these bisection errors can be attributed to a perceptual change whereby the patient experiences the left half of a line as shorter ...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1076/neur.7.5.391.16246

    authors: Pritchard CL,Dijkerman HC,McIntosh RD,Milner AD

    更新日期:2001-01-01 00:00:00

  • Cognition and functional performance in daily activities before and after pontine and extrapontine myelinolysis: a case study.

    abstract::Central pontine and extrapontine myelinolysis (CPEM) is a rare neurological condition usually due to rapid correction of hyponatremia. CPEM is mainly characterized by motor deficits (typically quadraparesis or extrapyramidal features) but neurobehavioral symptoms were also reported in the literature. However, very few...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2011.633528

    authors: Arciero S,Kempf C,Bernard F,Gosselin N

    更新日期:2012-01-01 00:00:00

  • Exaggerated color perception in a patient with visual form agnosia.

    abstract::Previous studies on visual form agnosic patients have shown that their color perception is relatively preserved when monochromatic figures are used. However, it is unclear whether their color perception remains normal when figures are composed of two parts in different colors. The results showed that patient X.F. had ...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554790701851569

    authors: Yang J,Wu M,Shen Z

    更新日期:2007-10-01 00:00:00

  • Influence of motor disorders on the visual perception of human movements in a case of peripheral dysgraphia.

    abstract::We report the case of a 71 year-old female patient (DC) with a left parietal lesion resulting in a peripheral dysgraphia essentially characterized by difficulties in letter sequences writing. The aim of our experiments was to analyze the influence of motor difficulties on the visual perception of both writing and reac...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554790490495113

    authors: Chary C,Méary D,Orliaguet JP,David D,Moreaud O,Kandel S

    更新日期:2004-06-01 00:00:00

  • Effects of mental rotation on acalculia: differences in the direction of mental rotation account for the differing characteristics of acalculia induced by right and left hemispheric brain injury.

    abstract::We observed a 59-year-old right-handed man with an infarction in his right-middle cerebral artery that included the parietal lobe, who abnormally manipulated mental images in the horizontal direction, resulting in calculation disturbances. Three years later, the patient suffered an infarction in the left parietal lobe...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2012.741254

    authors: Asada T,Takayama Y,Oita J,Fukuyama H

    更新日期:2014-04-01 00:00:00

  • Effects of self-esteem on electrophysiological correlates of easy and difficult math.

    abstract::The current study investigated the effects of easy versus difficult math on event-related potentials as a function of self-esteem in 28 undergraduate students. First, it was found that participants responded much more rapidly to an easy task. Second, the amplitude of P2 (150-300 ms) was more positive amplified in low ...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554794.2012.701636

    authors: Yang J,Zhao R,Zhang Q,Pruessner JC

    更新日期:2013-01-01 00:00:00

  • A slice of pi : an exploratory neuroimaging study of digit encoding and retrieval in a superior memorist.

    abstract::Subject PI demonstrated superior memory using a variant of a Method of Loci (MOL) technique to recite the first digits of the mathematical constant pi to more than 2(16) decimal places. We report preliminary behavioral, functional magnetic resonance imaging (fMRI), and brain volumetric data from PI. fMRI data collecte...

    journal_title:Neurocase

    pub_type: 杂志文章

    doi:10.1080/13554790902776896

    authors: Raz A,Packard MG,Alexander GM,Buhle JT,Zhu H,Yu S,Peterson BS

    更新日期:2009-10-01 00:00:00