Abstract:
:The degree of abnormality and rate of change in cognitive functions, positron emission tomography Pittsburg compound B (PET PIB), and fluorodeoxyglucose (FDG) measures were studied for 8 years in an autopsy-confirmed Alzheimer's disease (AD) patient, who died 61 years old (Mini-Mental State Examination (MMSE) score 7). At first encounter with medical care, the patient was very mildly demented (MMSE score 27). She had four cognitive assessments and two examinations with PET PIB and FDG in 23 bilateral brain regions. The onset of cognitive decline was retrospectively estimated to have started in the early forties. The degree of impairment was inversely related to the rate of decline. A similar relationship was seen between the rate of change and the level of abnormality in both PIB and FDG. To conclude, rate of change in cognition, PIB, and FDG was associated with the degree of abnormality.
journal_name
Neurocasejournal_title
Neurocaseauthors
Almkvist O,Kadir A,Nordberg Adoi
10.1080/13554794.2014.979835subject
Has Abstractpub_date
2015-01-01 00:00:00pages
738-47issue
6eissn
1355-4794issn
1465-3656journal_volume
21pub_type
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