Abstract:
:Neurophysiological and functional brain imaging studies suggest the importance of dorsolateral area 9/46 for modality-independent working memory. However, the behavioural manifestations following isolated damage to this area have not been clearly outlined. Here, we describe the dramatic derangement of pragmatic memory after circumscribed lesion of the right area 9/46. A 52 year-old woman had suffered a traumatic brain injury 13 years ago and sought help for what she thought was a severe memory disorder. She regularly missed appointments and had gradually lost all her friends. She had tried different strategies to compensate for her memory problem, such as writing notes on her wrist or using electronic organizers. Intelligence, attention, verbal long-term memory, and executive functions were normal. Furthermore, experimental exploration demonstrated intact time estimation, attribution of memories to ongoing reality, and anticipation of outcomes. However, she failed to rehearse and manipulate information in working memory (n-back task), confirming the findings of functional imaging studies that the mid-dorsolateral prefrontal cortex is involved in mental manipulation of information. This case exemplifies that an isolated lesion of the right area 9/46 may induce severe failure to schedule actions and memory retrieval, a disorder leading to severely disorganised behaviour and disability.
journal_name
Neurocasejournal_title
Neurocaseauthors
Ptak R,Schnider Adoi
10.1080/13554790490960495subject
Has Abstractpub_date
2004-02-01 00:00:00pages
52-9issue
1eissn
1355-4794issn
1465-3656pii
MEC9FRNANHYQGF9Yjournal_volume
10pub_type
杂志文章相关文献
NEUROCASE文献大全abstract::Metamemory is a multifaceted concept, which deals with an individual's knowledge and control of his or her own memory system. The ability to monitor memory performance accurately was examined in 16 patients with Alzheimer's disease (AD), 6 patients with frontotemporal lobe dementia (FTD) and 16 elderly subjects. Parti...
journal_title:Neurocase
pub_type: 临床试验,杂志文章
doi:10.1076/neur.9.6.482.29376
更新日期:2003-12-01 00:00:00
abstract::The concreteness effect occurs in both normal and language-disordered populations. Research suggests that abstract and concrete concepts elicit differing neural activation patterns in healthy young adults, but this is undocumented in persons with aphasia (PWA). Three PWA and three age-matched controls were scanned usi...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2013.770881
更新日期:2014-08-01 00:00:00
abstract::Both prosody and sentence structure (e.g., canonical versus non-canonical) affect sentence comprehension. However, few previous studies have examined a possible interaction between prosody and sentence structure. In adult controls we found a significant interaction: typical sentence prosody, versus list prosody, facil...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2019.1630447
更新日期:2019-01-01 00:00:00
abstract::We characterized the effect of virtual visual feedback (VVF) on supernumerary phantom limb pain (SPLP) in a patient with high cervical cord injury. The subject was a 22-year-old man diagnosed with complete spinal cord injury (level C2) approximately 5 years ago. We applied the ABA'B' single-case design and set phases ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2015.1011664
更新日期:2015-01-01 00:00:00
abstract::We present HP, a patient who following the occurrence of herpes simplex encephalitis, lost the ability to understand a subset of words while others remained preserved. Of particular interest is the fact that the meaningless items retained their lexical status. HP's immediate serial recall of meaningless words was thus...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1076/neur.8.3.255.16196
更新日期:2002-01-01 00:00:00
abstract::Neglect dyslexia is a reading disorder often associated with right-sided brain lesions. In reading single words, errors are mostly substitutions or omissions of letters that occupy the left-sided positions. Typically, these errors have been thought to depend on a single mechanism. Conversely, we propose that they are ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2010.498382
更新日期:2011-01-01 00:00:00
abstract::We observed a 59-year-old right-handed man with an infarction in his right-middle cerebral artery that included the parietal lobe, who abnormally manipulated mental images in the horizontal direction, resulting in calculation disturbances. Three years later, the patient suffered an infarction in the left parietal lobe...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2012.741254
更新日期:2014-04-01 00:00:00
abstract::Subject GSI presents with a graphemic buffer deficit following a massive left fronto-parietal lesion. His errors involved essentially only consonants (98.2%). However, he always spelled correctly the first consonant in a string, and produced steadily increasing numbers of errors on the following consonants, while alwa...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554790409609942
更新日期:2004-04-01 00:00:00
abstract::This case study describes the neurocognitive presentation of a child with identified genetic abnormalities of trisomy 6 and monosomy 21 who was evaluated as part of a standard medical protocol for cochlear implantation following diagnosis of profound sensorineural hearing loss. This child received neurocognitive testi...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554790802631910
更新日期:2009-01-01 00:00:00
abstract::In this paper, we adopt a neurodevelopmental stance to examining frontal variant frontotemporal dementia (fv-FTD) by using experimental procedures from the literature on the growth of social behaviour in children to examine the deficits in social reasoning which may underpin behavioural disturbance in fv-FTD. We prese...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1093/neucas/7.2.123
更新日期:2001-01-01 00:00:00
abstract::Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for Parkinson's disease, but can lead to adverse effects including psychiatric disturbance. Little is known about the risk factors and treatment options for such effects. Here, we describe a patient who reproducibly developed stimu...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2011.568502
更新日期:2012-01-01 00:00:00
abstract::We assessed visuospatial abilities in PCA. Sequential display of two simple geometric figures enhanced detection and discrimination relative to simultaneous display (Exps 1 & 2). Comparing edges of a single object enhanced discrimination relative to comparing edges of two separate objects, consistent with object-based...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2020.1729385
更新日期:2020-04-01 00:00:00
abstract::Primary progressive apraxia of speech (PPAOS) is a neurodegenerative disorder in which AOS is the sole presenting complaint. We report clinical and neuroimaging data spanning 10 years from disease onset-to-death in a 49 year-old male PPAOS patient, DY, who died with corticobasal degeneration. He presented with AOS wit...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2018.1477963
更新日期:2018-04-01 00:00:00
abstract::A 62-year-old male presented with progressive isolated writing and spelling difficulties. Neurological, neuropsychological, speech, and language evaluations identified only minimal additional abnormalities. The presenting characteristics did not meet criteria for any particular variant of primary progressive aphasia; ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2018.1454963
更新日期:2018-04-01 00:00:00
abstract::A 57-year-old male with no family history was diagnosed with semantic dementia. He also showed some unusual cognitive features such as episodic memory and executive dysfunctions, spatial disorientation, and dyscalculia. Rapidly progressive cognitive and physical decline occurred. About 1.5 years later, he developed cl...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2013.841953
更新日期:2015-02-01 00:00:00
abstract::Patients with memory disorders have severely restricted learning and memory. For instance, patients with anterograde amnesia can learn motor procedures and retain some restricted ability to learn new words and factual information. However, such learning is inflexible and frequently inaccessible to conscious awareness....
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554790903405701
更新日期:2010-06-01 00:00:00
abstract:UNLABELLED:Neuropathologic change underlying primary progressive aphasia (PPA) most commonly includes one of the frontotemporal lobar degenerations, such as FTLD-tau or FTLD-ubiquitin. The next most frequent etiology of PPA is Alzheimer's disease (AD). We describe 5 subjects with clinical diagnoses of semantic dementia...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554790903193174
更新日期:2010-02-01 00:00:00
abstract::The accurate prediction, at a pre-dementia stage of Alzheimer's disease (AD), of the subsequent clinical evolution of patients would be a major breakthrough from both therapeutic and research standpoints. Amnestic mild cognitive impairment (MCI) is presently the most common reference to address the pre-dementia stage ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554790490896938
更新日期:2005-02-01 00:00:00
abstract::Chediak-Higashi syndrome (CHS) is a rare autosomal disorder characterized by immunodeficiency, albinism, and progressive neurologic abnormalities. While survivors of the childhood-onset disease are known to exhibit learning disabilities and neuropsychiatric disorders followed by middle-age dementia, we lack detailed d...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2020.1856384
更新日期:2020-12-09 00:00:00
abstract::Subject PI demonstrated superior memory using a variant of a Method of Loci (MOL) technique to recite the first digits of the mathematical constant pi to more than 2(16) decimal places. We report preliminary behavioral, functional magnetic resonance imaging (fMRI), and brain volumetric data from PI. fMRI data collecte...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554790902776896
更新日期:2009-10-01 00:00:00
abstract::With injury of the anterior two-thirds of the corpus callosum, each hemisphere's attentional bias to contralateral hemispace becomes manifest with each hand deviating ipsilaterally during line bisection tasks. Patients with infarctions in the right posterior cerebral artery distribution with occipital and splenial dam...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2018.1539501
更新日期:2018-08-01 00:00:00
abstract::The degree of abnormality and rate of change in cognitive functions, positron emission tomography Pittsburg compound B (PET PIB), and fluorodeoxyglucose (FDG) measures were studied for 8 years in an autopsy-confirmed Alzheimer's disease (AD) patient, who died 61 years old (Mini-Mental State Examination (MMSE) score 7)...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2014.979835
更新日期:2015-01-01 00:00:00
abstract::A 54-year-old art teacher, experienced a right putaminal hemorrhage, and thereafter suffered severe left hemiplegia and unilateral spatial neglect, and was transferred to the rehabilitation department of the University Hospital 1 month after the onset. Although the unilateral spatial neglect was improving, the patient...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2011.588175
更新日期:2012-06-01 00:00:00
abstract::A current debate in the literature is whether all declarative memories and associated memory processes rely on the same neural substrate. Here, we show that H.C., a developmental amnesic person with selective bilateral hippocampal volume loss, has a mild deficit in personal episodic memory, and a more pronounced defic...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2010.532138
更新日期:2011-10-01 00:00:00
abstract::Previous research suggests that the noradrenergic system modulates flexibility of access to the lexical-semantic network, with propranolol benefiting normal subjects in lexical-semantic problem solving tasks. Patients with Broca's aphasia with anomia have impaired ability to access appropriate verbal output for a give...
journal_title:Neurocase
pub_type: 临床试验,杂志文章
doi:10.1080/13554790701595471
更新日期:2007-08-01 00:00:00
abstract::The brain's primary motor and primary somatosensory cortices are generally viewed as functionally distinct entities. Here we show by means of magnetoencephalography with a phantom-limb patient, that movement of the phantom hand leads to a change in the response of the primary somatosensory cortex to tactile stimulatio...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2013.873060
更新日期:2015-02-01 00:00:00
abstract::The clinical distinction between autism spectrum disorders (ASD), also called pervasive developmental disorders (PDD), and schizophrenia is often difficult to make. Here we describe a case of an adult patient presenting with a diagnosis of schizophrenia based on a history of functional deterioration and presumed perse...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554794.2012.713492
更新日期:2013-01-01 00:00:00
abstract::BVR was 77 years old when he sustained a large posterior cerebral artery territory infarct. Medical, cognitive and functional data collected on four occasions over 10 years initially revealed circumscribed neurological signs, no functional or cognitive deficits. BVR became significantly impaired only after two other s...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554790500502918
更新日期:2006-04-01 00:00:00
abstract::Cerebral lesions are held to induce plastic changes of the brain. Less well established, however, is how much space-occupying brain lesions may only displace functional representations. In a 66-year-old man we show, by means of functional magnetic resonance imaging and transcranial magnetic stimulation, a profound dis...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554790701849910
更新日期:2007-10-01 00:00:00
abstract::A 51-year-old right-handed man developed hypersexuality after a second right temporal lobectomy to treat epilepsy. His hypersexuality started with increased marital intercourse and masturbation but he later downloaded child pornography. Hyperphagia and distractibility, other features of the Kluver-Bucy syndrome, also ...
journal_title:Neurocase
pub_type: 杂志文章
doi:10.1080/13554790903329182
更新日期:2010-04-01 00:00:00