Pharmacological treatment of deep brain stimulation-induced hypomania leads to clinical remission while preserving motor benefits.

Abstract:

:Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for Parkinson's disease, but can lead to adverse effects including psychiatric disturbance. Little is known about the risk factors and treatment options for such effects. Here, we describe a patient who reproducibly developed stimulation-induced hypomania when using ventrally located electrodes and responded well to pharmacological intervention while leaving the stimulation parameters unchanged to preserve motor benefits. In spite of clinical remission, [¹⁵O]-positron-emission-tomography (PET) demonstrated activation patterns similar to those reported during mania. This case, therefore, highlights an important treatment option of adverse effects of DBS, but also points toward the need for investigations of its risk factors and their underlying neurobiological mechanisms.

journal_name

Neurocase

journal_title

Neurocase

authors

Schilbach L,Weiss PH,Kuhn J,Timmermann L,Klosterkötter J,Huff W

doi

10.1080/13554794.2011.568502

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

152-9

issue

2

eissn

1355-4794

issn

1465-3656

journal_volume

18

pub_type

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