Abstract:
:In a previous report, we presented longitudinal clinical, cognitive and anatomical data of a right-handed woman, whose clinical picture evolved from progressive nonfluent aphasia with apraxia of speech to corticobasal syndrome (CBS) in the last stage of the disease. The patient died at age 57 and pathological examination revealed severe atrophy in the left frontal operculum and left premotor area. On histological examination, there was diffuse tau-positive pathology in gray and white cortical hemispheric gray and white matter, basal ganglia and substantia nigra, compatible with corticobasal degeneration (CBD). This case demonstrates the clinical overlap between frontotemporal lobar degeneration and CBD. In this case, early motor speech impairment predicted earlier and more accurately than CBS the presence of underlying tau-pathology and CBD.
journal_name
Neurocasejournal_title
Neurocaseauthors
Sánchez-Valle R,Forman MS,Miller BL,Gorno-Tempini MLdoi
10.1080/13554790600977218subject
Has Abstractpub_date
2006-12-01 00:00:00pages
355-9issue
6eissn
1355-4794issn
1465-3656pii
X178126V04152538journal_volume
12pub_type
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