From progressive nonfluent aphasia to corticobasal syndrome: a case report of corticobasal degeneration.

Abstract:

:In a previous report, we presented longitudinal clinical, cognitive and anatomical data of a right-handed woman, whose clinical picture evolved from progressive nonfluent aphasia with apraxia of speech to corticobasal syndrome (CBS) in the last stage of the disease. The patient died at age 57 and pathological examination revealed severe atrophy in the left frontal operculum and left premotor area. On histological examination, there was diffuse tau-positive pathology in gray and white cortical hemispheric gray and white matter, basal ganglia and substantia nigra, compatible with corticobasal degeneration (CBD). This case demonstrates the clinical overlap between frontotemporal lobar degeneration and CBD. In this case, early motor speech impairment predicted earlier and more accurately than CBS the presence of underlying tau-pathology and CBD.

journal_name

Neurocase

journal_title

Neurocase

authors

Sánchez-Valle R,Forman MS,Miller BL,Gorno-Tempini ML

doi

10.1080/13554790600977218

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

355-9

issue

6

eissn

1355-4794

issn

1465-3656

pii

X178126V04152538

journal_volume

12

pub_type

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