Abstract:
:The purpose of this study was to determine whether myostatin alters glucose transporter-4 (GLUT4) expression in bovine skeletal muscles and myoblasts isolated from double-muscled (DM) and normal-muscled (NM) Japanese Shorthorn cattle. Plasma concentrations of glucose were lower in DM cattle than in NM cattle (P < 0.01). The expression of GLUT4 messenger RNA (mRNA) in the skeletal muscle ex vivo and in myoblasts at 72 h after differentiation in vitro was higher in DM cattle than in NM cattle (P < 0.01). In contrast, the NM and DM cattle did not differ with respect to skeletal muscle expression of GLUT1 and myocyte enhancer factor-2c (MEF2c), a transcription factor of GLUT4. In differentiated myoblasts, the expression of GLUT1, GLUT4, and MEF2c mRNAs was greater in DM cattle than in NM cattle (P < 0.01). In the presence and absence of insulin, glucose uptake in myoblasts was increased in DM cattle relative to that of NM cattle (P < 0.01). The addition of myostatin decreased the expression of GLUT4 and MEF2c mRNAs in DM myoblasts (P < 0.05). Results of the present study suggest that myostatin inhibits the expression of GLUT4 mRNA possibly via MEF2c and that the greater ability of the DM cattle to produce muscle relative to the NM cattle may be due to their greater sensitivity to insulin and greater use of glucose.
journal_name
Domest Anim Endocrinoljournal_title
Domestic animal endocrinologyauthors
Takahashi H,Sato K,Yamaguchi T,Miyake M,Watanabe H,Nagasawa Y,Kitagawa E,Terada S,Urakawa M,Rose MT,McMahon CD,Watanabe K,Ohwada S,Gotoh T,Aso Hdoi
10.1016/j.domaniend.2014.01.007subject
Has Abstractpub_date
2014-07-01 00:00:00pages
62-8eissn
0739-7240issn
1879-0054pii
S0739-7240(14)00008-3journal_volume
48pub_type
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2008.07.001
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章,随机对照试验
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2014.03.004
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
abstract::Remarkable diversity of size and health of offspring exists after normal pregnancies. When pregnancies are complicated by an extrinsic variable such as inappropriate maternal nutrition, birth weight and health of the neonate are substantially affected. The placenta is the organ through which respiratory gases, nutrien...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.domaniend.2004.06.006
更新日期:2004-10-01 00:00:00
abstract::Age-dependent interactions between environmental temperature and porcine growth hormone (pGH) treatment on the function of the somatotrophic axis were evaluated in the neonatal pig. At 3 d of age, 40 Landrace x Yorkshire x Duroc piglets received intraperitoneal implants containing either recombinant pGH (0.5 mg/d; n =...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/s0739-7240(99)00003-x
更新日期:1999-02-01 00:00:00
abstract::This study was performed to determine whether in dogs with pituitary-dependent hyperadrenocorticism (PDH) excessive release of adrenocorticotrophic hormone (ACTH) is accompanied by secretion of ACTH precursor molecules. In addition, we investigated whether the plasma ACTH precursor concentrations were correlated with ...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/s0739-7240(02)00128-5
更新日期:2002-06-01 00:00:00
abstract::The effects of increased postruminal supply of casein, corn starch, and soybean oil on plasma concentrations of the gastrointestinal hormones ghrelin and oxyntomodulin (OXM) were investigated. Four mid-lactation Holstein cows were used in a 4 x 4 Latin square. Treatments were continuous abomasal infusions (23 h/d) for...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2009.12.003
更新日期:2010-05-01 00:00:00