Abstract:
:The aim of this study was to determine the effects of growth hormone (GH) and insulin-like growth factor (IGF)-I on glycerol release and the regulation of IGF-I and IGF-II expression by GH in isolated rainbow trout adipocytes. Cells were also incubated with GH, tumor necrosis factor α (TNFα), or insulin to analyze the gene expression of peroxisome proliferator-activated receptors (PPARs) and lipid metabolism markers: hormone sensitive lipase, fatty acid synthase (FAS), and lipoprotein lipase. Complimentary in vivo experiments were performed by intraperitoneally administering insulin, TNFα, or lipopolysaccharide and subjecting the animals to fasting and refeeding periods. The results showed that IGF-I had an antilipolytic effect and GH had a lipolytic effect; the latter occurred independently of IGF modulation and in conjunction with a reduction in PPARα expression in adipocytes. The anabolic action of insulin was demonstrated through its upregulation of lipogenic genes such as lipoprotein lipase, FAS, and PPARγ, whereas GH, by contrast, inhibited FAS expression in adipose tissue. The gene transcription levels of PPARs changed differentially during fasting and refeeding, and the TNFα and/or lipopolysaccharide administration suggested that the regulation of PPARs helps maintain metabolic adipose tissue homeostasis in rainbow trout.
journal_name
Domest Anim Endocrinoljournal_title
Domestic animal endocrinologyauthors
Cruz-Garcia L,Sánchez-Gurmaches J,Monroy M,Gutiérrez J,Navarro Idoi
10.1016/j.domaniend.2014.11.002subject
Has Abstractpub_date
2015-04-01 00:00:00pages
86-95eissn
0739-7240issn
1879-0054pii
S0739-7240(14)00092-7journal_volume
51pub_type
杂志文章abstract::Twelve pregnant Brahman cows were randomly assigned to one of two treatment groups: 1) transported in a stock trailer for 24.2 km, unloaded at a second farm and penned for 1 hr, and then returned to the original farm (TRANS, n = 6); or 2) walked through the handling facilities (SHAM, n = 6). Treatments were repeated a...
journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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更新日期:1995-04-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Domestic animal endocrinology
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更新日期:2020-07-01 00:00:00
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更新日期:2001-04-01 00:00:00
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journal_title:Domestic animal endocrinology
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更新日期:2015-04-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2004.12.001
更新日期:2005-04-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/0739-7240(91)90064-q
更新日期:1991-04-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
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更新日期:1990-10-01 00:00:00
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2004.05.003
更新日期:2005-01-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-01-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章,评审
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更新日期:2000-08-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2013.04.003
更新日期:2013-07-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章,评审
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更新日期:2002-07-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2014.05.002
更新日期:2014-10-01 00:00:00
abstract::The effects of increased postruminal supply of casein, corn starch, and soybean oil on plasma concentrations of the gastrointestinal hormones ghrelin and oxyntomodulin (OXM) were investigated. Four mid-lactation Holstein cows were used in a 4 x 4 Latin square. Treatments were continuous abomasal infusions (23 h/d) for...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00