Abstract：
:Severe feed restriction decreases serum insulin-like growth factor I (IGF-I) concentration in animals, and this decrease is thought to be due to reduced IGF-I production in the liver. The objective of this study was to determine whether feed deprivation also increases degradation of serum IGF-I and serum levels of IGF binding protein 3 (IGFBP-3) and acid-labile subunit (ALS), which inhibit IGF-I degradation and increase IGF-I retention in the blood by forming a ternary complex with IGF-I, in cattle. Five steers had free access to pasture, and another five were deprived of feed for 60 h. Serum concentration of IGF-I and liver abundance of IGF-I mRNA at the end of the 60-h period were 50% and 80% lower, respectively, in feed-deprived steers than in fed steers. Less (125)I-labeled IGF-I remained intact after a 45-h incubation in sera of feed-deprived steers than in sera of fed steers, suggesting that serum IGF-I is more quickly degraded in feed-deprived animals. Serum levels of IGFBP-3 and ALS were decreased by 40% and 30%, respectively, in feed-deprived steers compared with fed steers. These decreases were associated with more than 50% reductions in IGFBP-3 and ALS mRNA in the liver, the major source of serum IGFBP-3 and ALS. Taken together, these results suggest that feed deprivation reduces serum concentration of IGF-I in cattle not only by decreasing IGF-I gene expression in the liver, but also by increasing IGF-I degradation and reducing IGF-I retention in the blood through decreasing IGFBP-3 and ALS production in the liver.
journal_name
Domest Anim Endocrinoljournal_title
Domestic animal endocrinologyauthors
Wu M,Wang A,Bernard GC,Hall JB,Beal WE,Michael Akers R,Boisclair YR,Jiang Hdoi
10.1016/j.domaniend.2008.07.003subject
Has Abstractpub_date
2008-11-01 00:00:00pages
343-51issue
4eissn
0739-7240issn
1879-0054pii
S0739-7240(08)00078-7journal_volume
35pub_type
杂志文章abstract：:The purpose of this study was to determine whether myostatin alters glucose transporter-4 (GLUT4) expression in bovine skeletal muscles and myoblasts isolated from double-muscled (DM) and normal-muscled (NM) Japanese Shorthorn cattle. Plasma concentrations of glucose were lower in DM cattle than in NM cattle (P < 0.01...
journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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更新日期：2007-02-01 00:00:00
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更新日期：2009-08-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/j.domaniend.2006.07.003
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/j.domaniend.2014.12.001
更新日期：2015-04-01 00:00:00
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/0739-7240(96)00013-6
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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更新日期：1987-07-01 00:00:00
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：2009-10-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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更新日期：1990-01-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：2007-05-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：2001-05-01 00:00:00
abstract：:A genome-wide association study had shown that lysine methyltransferase 2A (KMT2A), which encodes the histone 3 lysine 4 methyltransferase and reportedly can regulate gametogenesis, steroidogenesis, and development as well as other biological processes, is a potential candidate gene influencing litter size in the dair...
journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：2021-01-01 00:00:00
abstract：:Nutrition has long been known to have a profound influence on reproductive performance of female cattle, but the underlying mechanism remains poorly understood. Whilst early investigations focused on the modulation of nutrition on hypothalamic-pituitary axis, more recent studies have tested the hypothesis that metabol...
journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
doi：10.1016/s0739-7240(02)00159-5
更新日期：2002-07-01 00:00:00
