Abstract：
:The effect of endotoxin on follicular growth and on secretion of LH, estradiol-17beta, progesterone and cortisol during the proestrous phase in cattle was investigated. Holstein heifers were treated with PGF2alpha at 11-13 d after ovulation to induce luteolysis. At 42 hr after PGF2alpha treatment, heifers were administered either lipopolysaccharide (LPS; Escherichia coli, O111:B4, 5 microg/kg, n = 6) or saline (control; n = 6) by i.v. bolus injection. Ovarian structures were monitored daily by transrectal ultrasonography, and blood samples were collected at various times for hormonal analysis. The duration from PGF2alpha treatment to ovulation was significantly longer in the LPS group (8.0 +/- 1.3 d) than in the control group (4.2 +/- 0.2 d). LPS significantly reduced the pulse frequency of LH for 6 hr after the administration, and increased the mean concentration and pulse amplitude of LH from 3 to 6 hr after the administration. The plasma concentrations of progesterone and cortisol were transiently increased after LPS administration. The plasma concentration of estradiol-17beta was significantly decreased at 24 hr after LPS administration compared to that in the controls. Five of six LPS-treated heifers exhibited no preovulatory LH surge until 120 hr after PGF2alpha treatment and the remaining heifer exhibited the surge at 108 hr after PGF2alpha treatment, while the LH surge was observed at 54-78 hr after PGF2alpha treatment in control heifers. These results suggest that endotoxin disrupts progression of the proestrous phase of cattle, interrupting the preovulatory estradiol rise and thus delaying the LH surge and the subsequent ovulation.
journal_name
Domest Anim Endocrinoljournal_title
Domestic animal endocrinologyauthors
Suzuki C,Yoshioka K,Iwamura S,Hirose Hdoi
10.1016/s0739-7240(01)00098-4subject
Has Abstractpub_date
2001-05-01 00:00:00pages
267-78issue
4eissn
0739-7240issn
1879-0054pii
S0739-7240(01)00098-4journal_volume
20pub_type
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：2004-07-01 00:00:00
abstract：:This study examined the role of the adrenergic system in the regulation of growth hormone (GH) secretion in sheep. Intravenous infusion of noradrenaline (0.5 microgram/kg per min for 2 hr) totally suppressed plasma GH concentrations. Concomitant treatment of animals with the beta-adrenergic antagonist propranolol comp...
journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/0739-7240(94)90026-4
更新日期：1994-04-01 00:00:00
