Effect of stage of lactation and gestation on milking-induced hormone release in lactating dairy cows.


:Three experiments were conducted to better understand why milking-induced prolactin (PRL) release decreases as lactation advances. Experiment 1 compared the effects of milking, 2-min manual stimulation of the mammary gland (without milking), or injection of 1 IU of oxytocin (without milking) on hormonal release in early lactation cows, late-lactation and nongestating cows, and late-lactation and gestating cows (n = 6 per physiological status). Blood samples were collected from 20 min before the start of the treatments to 60 min after. During milking, PRL release (area under the curve above the baseline) was greater in the early lactation cows than in the late-lactation cows but was unaffected by gestation. Lactation stage and gestation did not affect PRL release by manual stimulation. Oxytocin did not induce a significant release of PRL or cortisol. Cortisol release was unaffected by physiological status and was similar for milking and mammary stimulation. Milking-induced β-endorphin release was not affected by physiological status. Experiment 2 compared the effects of milking, 2-min manual stimulation, or 10-min manual stimulation in cows in early (n = 6) and late (n = 6) lactation. Prolactin release was greater in the early lactation cows than in the late-lactation cows for all 3 treatments. A 10-min manual stimulation induced greater PRL release than a 2-min stimulation did. Cortisol release was greater in the early lactation cows but was similar among the 3 treatments. Experiment 3 compared the effects of a 5-min manual stimulation and the injection of domperidone (a dopamine antagonist) in cows in early (n = 6) and late (n = 6) lactation. Manually induced PRL release was greater in the early lactation cows than in the late-lactation cows. Prolactin release was greater with domperidone injection than with manual stimulation and was not affected by lactation stage. Thus, the reduction of milking-induced PRL release in late lactation is not a consequence of the lower sensitivity of the mammary gland to stimulation, a shorter milking time, the gestation stage, or the reduced capacity of the pituitary gland to secrete PRL.


Domest Anim Endocrinol


Lacasse P,Zhao X,Ollier S




Has Abstract


2019-01-01 00:00:00












  • Differences between primiparous and multiparous dairy cows in the inter-relationships between metabolic traits, milk yield and body condition score in the periparturient period.

    abstract::During the early postpartum period dairy cows mobilize fat and muscle to support lactation. This is associated with alterations in blood metabolite and hormone profiles which in turn influence milk yield and fertility. This study developed models to determine how metabolic traits, milk yield and body condition score w...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Wathes DC,Cheng Z,Bourne N,Taylor VJ,Coffey MP,Brotherstone S

    更新日期:2007-08-01 00:00:00

  • Regulation of lipid metabolism and peroxisome proliferator-activated receptors in rainbow trout adipose tissue by lipolytic and antilipolytic endocrine factors.

    abstract::The aim of this study was to determine the effects of growth hormone (GH) and insulin-like growth factor (IGF)-I on glycerol release and the regulation of IGF-I and IGF-II expression by GH in isolated rainbow trout adipocytes. Cells were also incubated with GH, tumor necrosis factor α (TNFα), or insulin to analyze the...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Cruz-Garcia L,Sánchez-Gurmaches J,Monroy M,Gutiérrez J,Navarro I

    更新日期:2015-04-01 00:00:00

  • Normal and disturbed milk ejection in dairy cows.

    abstract::More than 80% of the milk stored in the udder, i.e. the alveolar fraction, only available after milk ejection is induced by the release of oxytocin and myoepithelial contraction. Milk ejection is induced by tactile teat stimulation, either manually or by the milking machine. The time from the start of a tactile stimul...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章,评审


    authors: Bruckmaier RM

    更新日期:2005-08-01 00:00:00

  • Effects of post-weaning supplementation of immunomodulatory feed ingredient on body weight and cortisol concentrations in program-fed beef heifers.

    abstract::The objective of this study was to determine the effects of an immunomodulatory feed ingredient during post-weaning on growth and cortisol concentrations of beef heifers. Commercial Angus heifers (n = 72) from 2 AI sires were blocked (n = 9) by BW and randomly assigned to one of 2 pens per block. Each pen (4 heifers/p...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Danielo J,McCarty KJ,Tipton JE,Ricks RE,Long NM

    更新日期:2020-07-01 00:00:00

  • Relative prolactin-to-progesterone concentrations around farrowing influence colostrum yield in primiparous sows.

    abstract::In swine, colostrum production is induced by the drop of progesterone (P4) concentrations which leads to the prepartum peak of prolactin (PRL). PRL regulates mammary cell turnover and stimulates lacteal nutrient synthesis. P4 inhibits PRL secretion and downregulates the PRL receptor in the mammary gland. The aim of th...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Loisel F,Farmer C,van Hees H,Quesnel H

    更新日期:2015-10-01 00:00:00

  • C-terminal telopeptide of type I collagen, osteocalcin, alkaline phosphatase, and parathyroid hormone in healthy and hospitalized foals.

    abstract::Hypocalcemia is a common finding in critically ill equine patients. Parathyroid hormone (PTH) helps to maintain calcium homeostasis in hypocalcemic patients by promoting renal calcium reabsorption and bone resorption. Increased serum PTH concentrations have been reported in critically ill people and animals, including...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Kamr AM,Dembek KA,Gilsenan W,Bozorgmanesh R,Hassan HY,Rosol TJ,Toribio RE

    更新日期:2020-07-01 00:00:00

  • Effects of domperidone and thyrotropin-releasing hormone on secretion of luteinizing hormone and prolactin during the luteal phase and following induction of luteal regression in sheep.

    abstract::Effects of domperidone, a peripheral dopamine receptor antagonist, on secretion of LH and prolactin were studied during the luteal phase and following administration of PGF2 alpha. Since hyperprolactinemia has been reported to inhibit secretion of LH in ewes, effects of thyrotropin-releasing hormone (TRH) also were ex...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Deaver DR,Keisler DH,Dailey RA

    更新日期:1987-04-01 00:00:00

  • Poor maternal nutrition during gestation in sheep reduces circulating concentrations of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in offspring.

    abstract::To determine if poor maternal nutrition alters growth, body composition, circulating growth factors, and expression of genes involved in the development of muscle and adipose of offspring, 24 Dorset and Shropshire ewes were fed either 100% (control fed), 60% (restricted fed), or 126% (over fed) of National Research Co...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Hoffman ML,Rokosa MA,Zinn SA,Hoagland TA,Govoni KE

    更新日期:2014-10-01 00:00:00

  • Hyperthermic and endocrine effects of intravenous prostaglandin administration in the pig.

    abstract::Experimentally induced fever is accompanied by a variety of hormonal changes, and there is evidence to suggest that some of these responses may be mediated by prostaglandins. However, little is known about the endocrine effects of peripherally administered prostaglandins, especially in domesticated species. In this st...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Parrott RF,Vellucci SV,Forsling ML,Goode JA

    更新日期:1995-04-01 00:00:00

  • Characteristics, tissue-specific expression, and hormonal regulation of expression of tyrosine aminotransferase in the avian female reproductive tract.

    abstract::Tyrosine aminotransferase (TAT) catalyzes the transamination of tyrosine to p-hydroxyphenylpyruvate. Accumulation of tyrosine in the body due to a genetic mutation in the TAT gene causes tyrosomia type II in humans. The TAT gene is regarded as a model for studying steroid-inducible factors regulating a variety of biol...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Lim W,Song G

    更新日期:2016-10-01 00:00:00

  • Plasma levels of cortisol and corticosteroid-binding globulin (CBG) and hepatic CBG mRNA expression in pre- and postnatal pigs.

    abstract::The relationships among hepatic corticosteroid-binding globulin (CBG) mRNA expression and plasma concentrations of cortisol and CBG was evaluated in fetal pigs (n=7-14 per age) on days 50, 70, 80, 90, and 104 of gestation and postnatal pigs (n=8 per age) on days 1, 3, 10, 20, 30, and 40 following birth. In fetal pigs,...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Heo J,Kattesh HG,Roberts MP,Schneider JF

    更新日期:2003-10-01 00:00:00

  • Effect of nutrient intake during pregnancy on fetal and placental growth and vascular development.

    abstract::Remarkable diversity of size and health of offspring exists after normal pregnancies. When pregnancies are complicated by an extrinsic variable such as inappropriate maternal nutrition, birth weight and health of the neonate are substantially affected. The placenta is the organ through which respiratory gases, nutrien...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章,评审


    authors: Redmer DA,Wallace JM,Reynolds LP

    更新日期:2004-10-01 00:00:00

  • Hormone interactions confer specific proliferative and histomorphogenic responses in the porcine mammary gland.

    abstract::Mammary gland growth and morphogenesis are regulated by interactions between hormones as much as by their individual actions. The effect of these interactions on the mammary gland phenotype in species other than rodents is relatively undefined. We investigated the individual and combined effects of estrogen (E), proge...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Horigan KC,Trott JF,Barndollar AS,Scudder JM,Blauwiekel RM,Hovey RC

    更新日期:2009-08-01 00:00:00

  • In vitro supplementation of testosterone or prolactin affects spermatozoa freezability in small ruminants.

    abstract::In small ruminants, testosterone and prolactin plasma concentrations show circannual fluctuations as an adaptation mechanism to their seasonal breeding behavior. Sperm resistance to the freezing-thawing process shows seasonal fluctuation throughout the year, with lower sperm freezability at the beginning of the breedi...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Martínez-Fresneda L,O'Brien E,López Sebastián A,Velázquez R,Toledano-Díaz A,Tesfaye D,Schellander K,García-Vázquez FA,Santiago-Moreno J

    更新日期:2020-07-01 00:00:00

  • Genetically caused retarded growth in animals.

    abstract::Growth process of animals is regulated by a multitude of physiological pathways among which components of the somatotropic axis play a key role. A number of severe, simply inherited growth disturbances have been identified in humans, laboratory and farm animals. These disorders are controlled by defective alleles at m...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章,评审


    authors: Sellier P

    更新日期:2000-08-01 00:00:00

  • Milk production correlates negatively with plasma levels of pregnancy-associated glycoprotein (PAG) during the early fetal period in high producing dairy cows with live fetuses.

    abstract::This study was designed to establish possible factors affecting plasma pregnancy-associated glycoprotein (PAG) concentrations during early pregnancy in high producing dairy cows with live fetuses. Blood samples were obtained on days 35, 42, 49, 56 and 63 of gestation from 80 lactating cows in two herds carrying live f...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: López-Gatius F,Garbayo JM,Santolaria P,Yániz J,Ayad A,de Sousa NM,Beckers JF

    更新日期:2007-01-01 00:00:00

  • Mutations in growth hormone gene affect stability of protein structure leading to reduced growth, reproduction, and milk production in crossbred cattle-an insight.

    abstract::The GH has a multifaceted role in growth, reproduction, and milk production. Nonsynonymous mutations identified as L153V were observed from GH1 (L) to GH2 (V) with higher genotypic frequency for GH1 being 0.87. GH2 (V) allele was identified as a rare allele and the population followed Hardy-Weinberg equilibrium. LL ho...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Pal A,Pal A,Chakravarty AK

    更新日期:2020-04-01 00:00:00

  • Changes in vasotocin immunoreactivity of paraventricular nuclei and adrenal function of Japanese quail in relation to different phases of sexual development.

    abstract::In relevance to osmoregulatory and reproductive functions, activity of hypothalamic neurosecretory neurons may also vary seasonally. The current study was performed to determine annual changes in ir-AVT neurons of hypothalamus and adrenal gland function. We examined changes in ir-AVT neuron by immunohistochemical meth...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Singh S,Chaturvedi CM

    更新日期:2008-04-01 00:00:00

  • Proopiomelanocortin processing and prohormone convertase 1 level in dogs with pituitary corticotroph tumors.

    abstract::Preliminary data suggest that prohormone convertase 1 (PC1/3) protein expression and proopiomelanocortin (POMC) processing are altered in large corticotroph tumors. The aim of this study was to characterize the levels of ACTH precursors and PC1/3 protein in small and large corticotroph tumors of dogs with Cushing's di...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Benchekroun G,de Fornel-Thibaud P,Rosenberg D

    更新日期:2018-01-01 00:00:00

  • Plasma cortisol responses to remote adrenocorticotropic hormone (ACTH) infusion in free-ranging red deer (Cervus elaphus).

    abstract::A remote infusion and blood collection device (Dracpac) was used on free-ranging red deer stags to deliver i.v. a range of ACTH1-24 doses and collect blood for cortisol determination. In Experiment 1, conducted in September, saline and 1, 4, and 16 IU ACTH/100 kg bodyweight were infused (n = 5-7 per treatment). In Exp...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Ingram JR,Matthews LR,Carragher JF,Schaare PR

    更新日期:1997-01-01 00:00:00

  • Oxytocin-neurophysin I mRNA abundance in equine uterine endometrium.

    abstract::A positive-feedback loop between luteal oxytocin and uterine prostaglandin F2 alpha (PGF) is a major signal for luteolysis in ruminants. Likewise, uterine PGF causes luteolysis in mares, but the involvement of oxytocin in this process is unclear. We wanted: 1) to determine if the oxytocin-neurophysin I (OT-NP I) gene ...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Behrendt-Adam CY,Adams MH,Simpson KS,McDowell KJ

    更新日期:1999-04-01 00:00:00

  • Ovarian follicle populations and ovulation rates of Finnish Landrace cross ewes in different nutritional states and associated profiles of gonadotrophins, inhibin, growth hormone(GH) and insulin-like growth factor-I.

    abstract::Effects of ewe body condition and level of feed intake on ovarian follicle populations and ovulation rates were studied in three groups of 12 to 15 Finnish Landrace cross ewes. Ewes were fed to achieve target body condition scores of either 2.0 (low, LM) or 2.5 (moderate, MM) and then fed a complete pelleted ration fo...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Rhind SM,Schanbacher BD

    更新日期:1991-04-01 00:00:00

  • Effects of somatostatin immunoneutralization on growth and endocrine parameters in chickens.

    abstract::The effects of somatostatin immunoneutralization on growth rate, growth hormone (GH) secretion and circulating insulin-like growth factor I (IGF-I) concentrations were investigated in chickens through the use of passive and active immunization techniques. Intravenous bolus injection of goat-antisomatostatin stimulated...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Buonomo FC,Sabacky MJ,Della-Fera MA,Baile CA

    更新日期:1987-07-01 00:00:00

  • Adrenomedullin (AM) and adrenomedullin binding protein (AM-BP) in the bovine mammary gland and milk: Effects of stage of lactation and experimental intramammary E. coli infection.

    abstract::Adrenomedullin (AM) has been characterized as an endogenous tissue survival factor and modulator of many inflammatory processes. Because of the increased susceptibility of the mammary gland to infection during the time surrounding parturition in the cow, we investigated how milk and tissue content of AM and its bindin...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Elsasser TH,Capuco AV,Caperna TJ,Martínez A,Cuttitta F,Kahl S

    更新日期:2007-02-01 00:00:00

  • Effects of N-methyl-D, L-aspartate on secretion of growth hormone-releasing hormone from the boar hypothalamic-preoptic area and median eminence in vitro.

    abstract::N-methyl-D, L-aspartate (NMA) elicited secretion of growth hormone (GH)-releasing hormone from both the hypothalamic-preoptic area and the median eminence that were collected from boars. We suggest that the previously described increase in GH secretion that follows peripheral treatment of swine with NMA is attributabl...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Estienne MJ,McElwain KV,Barrett JB,Barb CR

    更新日期:1999-11-01 00:00:00

  • Determinants of attenuated LH-release associated with the first ovulation of the equine breeding season.

    abstract::An attenuated ovulatory rise in circulating concentrations of LH is characteristically associated with the first seasonal reproductive cycle of horse mares. Unlike ovulations (OV) of subsequent estrous cycles, the first OV of the breeding season (OV1) is not preceded by elevated concentrations of progesterone (PROG). ...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Silvia PJ,Fitzgerald BP

    更新日期:1991-04-01 00:00:00

  • The neuroendocrinology of reproductive behavior in Japanese quail.

    abstract::Sex steroid hormones such as testosterone have widespread effects on brain physiology and function but one of their best characterized effects arguably involves the activation of male sexual behavior. During the past 20 years we have investigated the testosterone control of male sexual behavior in an avian species, th...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章,评审


    authors: Balthazart J,Baillien M,Charlier TD,Cornil CA,Ball GF

    更新日期:2003-07-01 00:00:00

  • Role of luteal biosynthesis of prostaglandin F2α on function and structure of the corpus luteum during luteolysis in heifers.

    abstract::The role of endogenous prostaglandin F2α (PGF) in the induction of luteolysis by exogenous PGF was studied by simultaneous inhibition of endogenous PGF with flunixin meglumine (FM). Groups were controls (n = 8), PGF treated (n = 8), and FM + PGF treated (n = 9). Treatments were given 10 d postovulation at hours 0, 8, ...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Pinaffi FLV,Araujo ER,Ginther OJ

    更新日期:2018-04-01 00:00:00

  • Study of the hepatic growth hormone (GH) receptor at different ages in chickens selected for a good feed conversion (FC) and a fast weight gain (GL).

    abstract::The influence of genetic selection for improved feed conversion (FC) and fast growth (GL) in broiler chickens, on the hepatic growth hormone receptor was investigated as a function of age. Selection for improved feed conversion resulted in lean chickens, whereas selection for fast growth resulted in fat chickens. Grow...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章


    authors: Vanderpooten A,Janssens W,Buyse J,Leenstra F,Berghman L,Decuypere E,Kühn ER

    更新日期:1993-07-01 00:00:00

  • Role of tumor necrosis factor-alpha and nitric oxide in luteolysis in cattle.

    abstract::Although prostaglandin (PG) F2alpha is known to be a principal luteolytic factor, its action on the bovine corpus luteum (CL) is mediated by other intra-ovarian factors. Tumor necrosis factor-alpha (TNFalpha) and its specific receptors are present in the bovine CL with the highest expressions at luteolysis. TNFalpha i...

    journal_title:Domestic animal endocrinology

    pub_type: 杂志文章,评审


    authors: Skarzynski DJ,Jaroszewski JJ,Okuda K

    更新日期:2005-08-01 00:00:00