Abstract：
:Glucagon-like peptide-1 (GLP-1) is an intestinal hormone that induces glucose-dependent stimulation of insulin secretion while suppressing glucagon secretion. Glucagon-like peptide-1 also increases beta cell mass and satiation while decelerating gastric emptying. Liraglutide is a fatty-acid derivative of GLP-1 with a protracted pharmacokinetic profile that is used in people for treatment of type II diabetes mellitus and obesity. The aim of this study was to determine the pharmacokinetics and pharmacodynamics of liraglutide in healthy cats. Hyperglycemic clamps were performed on days 0 (HGC) and 14 (LgHGC) in 7 healthy cats. Liraglutide was administered subcutaneously (0.6 mg/cat) once daily on days 8 through 14. Compared with the HGC (mean ± standard deviation; 455.5 ± 115.8 ng/L), insulin concentrations during LgHGC were increased (760.8 ± 350.7 ng/L; P = 0.0022), glucagon concentrations decreased (0.66 ± 0.4 pmol/L during HGC vs 0.5 ± 0.4 pmol/L during LgHGC; P = 0.0089), and there was a trend toward an increased total glucose infused (median [range] = 1.61 (1.11-2.54) g/kg and 2.25 (1.64-3.10) g/kg, respectively; P = 0.087). Appetite reduction and decreased body weight (9% ± 3%; P = 0.006) were observed in all cats. Liraglutide has similar effects and pharmacokinetics profile in cats to those reported in people. With a half-life of approximately 12 h, once daily dosing might be feasible; however, significant effects on appetite and weight loss may necessitate dosage or dosing frequency reductions. Further investigation of liraglutide in diabetic cats and overweight cats is warranted.
journal_name
Domest Anim Endocrinoljournal_title
Domestic animal endocrinologyauthors
Hall MJ,Adin CA,Borin-Crivellenti S,Rudinsky AJ,Rajala-Schultz P,Lakritz J,Gilor Cdoi
10.1016/j.domaniend.2014.12.001subject
Has Abstractpub_date
2015-04-01 00:00:00pages
114-21eissn
0739-7240issn
1879-0054pii
S0739-7240(14)00109-Xjournal_volume
51pub_type
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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pub_type： 杂志文章,评审
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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abstract：:The ability of the neurohormone melatonin to ameliorate cryopreservation-induced damage to spermatozoa has been demonstrated in several domestic species. However, it is unclear how these protective effects are conferred, with improvements in sperm quality ambiguously attributed to the general antioxidant activity of m...
journal_title：Domestic animal endocrinology
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更新日期：2021-01-01 00:00:00
abstract：:The effects of estrogen and fasting on hepatic metabolism were studied by an arteriovenous difference technique in six multicatheterized ewes. In each experiment samples were collected during fed and 3- and 5-day fasted states before, and 10 to 17 days after the animals had been implanted with 550 mg of estradiol-17 b...
journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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abstract：:Four experiments were conducted to evaluate the accuracy and reliability of noninvasive evaluation of cortisol in saliva of dogs. In experiment 1, we measured the cortisol concentration in the filter paper on which 250-μL cortisol solutions had been quantitatively pipetted and in filter papers dipped in cortisol solut...
journal_title：Domestic animal endocrinology
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