Ontogeny of the hypothalamo-pituitary-adrenocortical axis in the chicken embryo: a review.

Abstract:

:The embryo of the domestic fowl (Gallus domesticus) tenders one distinctive advantage over general mammalian models for investigating the development of the hypothalamo-pituitary-adrenocortical (HPA) axis. This is the relative simplicity with which the embryonic endocrine environment can be influenced without confounding maternal influences. The ease of direct manipulation of the embryonic endocrine system has facilitated analysis of the development and function of the HPA axis in the chick embryo. As the chick embryo develops, functional activation of the adrenal gland is regulated at three different levels: the adrenal gland itself, the anterior pituitary, and the hypothalamus. The adrenal gland appears capable of independent secretion of glucocorticoids from day 8 until shortly after day 14 of embryonic development, at which point the pituitary influences adrenocortical activity. Around the same age, the hypothalamic level of control also begins. The information covered in this review will describe the major steps in the development of the HPA axis in the chicken embryo and show that the chicken has an emblematic HPA neuroendocrine axis.

journal_name

Domest Anim Endocrinol

authors

Jenkins SA,Porter TE

doi

10.1016/j.domaniend.2004.01.001

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

267-75

issue

4

eissn

0739-7240

issn

1879-0054

pii

S0739724004000116

journal_volume

26

pub_type

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