Abstract：
:Pituitary-dependent hyperadrenocorticism (PDH) in dogs is caused by a pituitary corticotroph adenoma. Although PDH is a common disorder in dogs, little is known about the underlying pathogenesis. In the pituitary glands of humans and mice, the pro-opiomelanocortin (POMC)-expressing cell lineages, the corticotrophs and melanotrophs, have a specific marker in common, the T-box transcription factor Tpit (Tbx19), which is obligate for POMC expression. Tpit also regulates the late differentiation of the corticotrophs and melanotrophs, and therefore may contribute to the pathogenesis of the corticotroph adenomas. The aim of this study was to perform an expression and mutation analysis of Tpit in the normal canine pituitary and in corticotroph adenomas. The distribution of the Tpit protein in the pituitary gland was studied with immunohistochemistry and the expression of the gene with RT-PCR. The coding region of Tpit cDNA from 14 dogs with PDH was screened for mutations. Tpit was expressed in corticotroph and melanotroph cells of the normal and adenomatous canine pituitary, and remained present in non-adenomatous corticotrophs of pituitaries from PDH dogs. No tumor-specific mutation in the Tpit cDNA from the corticotroph adenomas was found. However, a missense polymorphism in the highly conserved DNA-binding domain, the T-box, was discovered in one dog. It is concluded that Tpit can be used as a reliable marker for the corticotroph and melanotroph cells in the canine pituitary tissue and that mutations in the Tpit gene are unlikely to play a major role in the pathogenesis of canine corticotroph adenomas.
journal_name
Domest Anim Endocrinoljournal_title
Domestic animal endocrinologyauthors
Hanson JM,Mol JA,Leegwater PA,Bilodeau S,Drouin J,Meij BPdoi
10.1016/j.domaniend.2007.03.002subject
Has Abstractpub_date
2008-04-01 00:00:00pages
217-22issue
3eissn
0739-7240issn
1879-0054pii
S0739-7240(07)00075-6journal_volume
34pub_type
杂志文章abstract：:It has been suggested that there is a shift in steroidogenic pathways of the theca layer from delta 5 to delta 4 during follicular maturation in the chicken ovary. However, the preferred steroid metabolic pathway in the theca and granulosa layers of small and preovulatory follicles has not been identified. Therefore, ...
journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/s0739-7240(97)00057-x
更新日期：1998-01-01 00:00:00
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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更新日期：2002-07-01 00:00:00
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journal_title：Domestic animal endocrinology
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更新日期：1994-01-01 00:00:00
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journal_title：Domestic animal endocrinology
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更新日期：2015-10-01 00:00:00
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journal_title：Domestic animal endocrinology
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更新日期：2014-04-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,随机对照试验
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更新日期：2016-10-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/0739-7240(92)90010-u
更新日期：1992-01-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/0739-7240(94)00009-p
更新日期：1995-01-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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更新日期：2016-07-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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更新日期：1998-09-01 00:00:00
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journal_title：Domestic animal endocrinology
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更新日期：2005-11-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：2021-01-01 00:00:00
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journal_title：Domestic animal endocrinology
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更新日期：2018-10-01 00:00:00
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：1999-02-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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更新日期：2003-07-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/j.domaniend.2019.03.001
更新日期：2020-07-01 00:00:00
