Abstract:
:Sex steroid hormones such as testosterone have widespread effects on brain physiology and function but one of their best characterized effects arguably involves the activation of male sexual behavior. During the past 20 years we have investigated the testosterone control of male sexual behavior in an avian species, the Japanese quail (Coturnix japonica). We briefly review here the main features and advantages of this species relating to the investigation of fundamental questions in the field of behavioral neuroendocrinology, a field that studies inter-relationship among hormones, brain and behavior. Special attention is given to the intracellular metabolism of testosterone, in particular its aromatization into an estrogen, which plays a critical limiting role in the mediation of the behavioral effects of testosterone. Brain aromatase activity is controlled by steroids which increase the transcription of the enzyme, but afferent inputs that affect the intraneuronal concentrations of calcium also appear to have a pronounced effect on the enzyme activity through rapid changes in its phosphorylation status. The physiological significance of these slow genomic and rapid, presumably non-genomic, changes in brain aromatase activity are also briefly discussed.
journal_name
Domest Anim Endocrinoljournal_title
Domestic animal endocrinologyauthors
Balthazart J,Baillien M,Charlier TD,Cornil CA,Ball GFdoi
10.1016/s0739-7240(03)00046-8subject
Has Abstractpub_date
2003-07-01 00:00:00pages
69-82issue
1eissn
0739-7240issn
1879-0054pii
S0739724003000468journal_volume
25pub_type
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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