Abstract：
:The high rate of fixation failure in osteoporotic proximal humerus fractures indicate the need for improved solutions. Computer simulations may help to overcome the limitations of the gold standard biomechanical testing in evaluating the performance of new implants and enhance the effectivity and outcome of the design process. This study presents a framework for automated computational analysis that facilitates efficient and systematic evaluation of proximal humerus fracture plating under a variety of conditions including bone quality, fracture pattern, implant configuration and loading regime. The underlying finite element methodology was previously validated. The capabilities of the software tool are demonstrated by virtually reproducing a previously published biomechanical study on the effect of screw augmentation and showing that the models capture the essence of the experimental results. Due to the modular design of the framework, the currently available set of angle-stable plate implants can be readily expanded to include other fixations such as intramedullary nails. Besides the capability to compare already existing solutions, the tool can provide rapid feedback on novel ideas. Therefore, it is expected to efficiently complement and partially replace expensive experimental tests and aid development and optimization of implant designs for improved fixation of osteoporotic proximal humerus fractures.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Varga P,Inzana JA,Gueorguiev B,Südkamp NP,Windolf Mdoi
10.1016/j.medengphy.2018.04.011subject
Has Abstractpub_date
2018-07-01 00:00:00pages
29-39eissn
1350-4533issn
1873-4030pii
S1350-4533(18)30065-1journal_volume
57pub_type
杂志文章abstract：:The prerequisite for the continuous in vivo monitoring of glucose concentration is the development of an implantable glucose sensor with long-term stability. A new enzyme electrode concept featuring fluid-state glucose oxidase modified carbon powder along with a cross-linked glucose oxidase enzyme layer has been devel...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/1350-4533(90)90008-v
更新日期：1994-09-01 00:00:00
abstract：:The potential for a simple, non-invasive measure of respiratory effort based on the pulse oximeter signal - the photoplethysmogram or 'pleth' - was investigated in a pilot study. Several parameters were developed based on a variety of manifestations of respiratory effort in the signal, including modulation changes in ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.12.010
更新日期：2017-03-01 00:00:00
abstract：:Lung cancer is the most common cause of cancer-related death, and early detection can reduce the mortality rate. Patients with lung nodules greater than 10 mm usually undergo a computed tomography (CT)-guided biopsy. However, aligning the needle with the target is difficult and the needle tends to deflect from a strai...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2017.04.009
更新日期：2017-07-01 00:00:00
abstract：:Contamination of EEG signals by artefacts arising from head movements has been a serious obstacle in the deployment of automatic neurological event detection systems in ambulatory EEG. In this paper, we present work on categorizing these head-movement artefacts as one distinct class and on using support vector machine...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.08.017
更新日期：2013-07-01 00:00:00
abstract：:Tripolar systems have been implanted to reduce the risk of recurrent dislocation. However, there is little known about the dynamic behavior of tripolar hip endoprostheses under daily life conditions and achieved joint stability. Hence, the objective of this biomechanical study was to examine the in vivo dynamics and d...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2013.09.007
更新日期：2014-01-01 00:00:00
abstract：:Easy insertion of the implant and stable bone purchase is essential for an ideal dental implantation. At the implant tip, the cutting flutes and conical profile are respectively designed to reduce insertion resistance and facilitate the initial insertion. However, the tapered tip might reduce the self-tapping and bone...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.09.021
更新日期：2012-09-01 00:00:00
abstract：:The present paper presents a homogenisation technique applied to the problem of calculating equivalent material properties of a resin impregnated wire mesh. Although this type of material can be expected to possess, in general, a four-fold axis of rotational symmetry, it was found that a transversally isotropic model ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(00)00065-5
更新日期：2000-09-01 00:00:00
abstract：:In this paper we investigate the extent to which variable porosity drug-eluting coatings can provide better control over drug release than coatings where the porosity is constant throughout. In particular, we aim to establish the potential benefits of replacing a single-layer with a two-layer coating of identical tota...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2017.04.006
更新日期：2017-07-01 00:00:00
abstract：:The acetabular cup (AC) is an implant impacted into a bone cavity and used for hip prosthesis surgery. Initial stability of the AC is an important factor for long term surgical success. The aim of this study is to determine the variations of the impact duration during AC implant insertion. Twenty-two bone samples take...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2013.04.005
更新日期：2013-11-01 00:00:00
abstract：:Unlike primary stability of coated cementless implants, their secondary stability has been poorly studied. This paper considers some theoretical aspects of the secondary stability of a coated cementless hip implant in a human femur. The bone is separated from the implant by a thin layer of microscopic peaks and trough...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(03)00099-7
更新日期：2003-12-01 00:00:00
abstract：:We investigated whether automatic control of a hand grasp neuroprosthesis by means of signals from natural sensors in the skin of the index finger can mimic the natural control of grasp force in an important task of daily living, namely eating. We designed a simulated eating task with the same ratio of rest and activi...
journal_title：Medical engineering & physics
pub_type： 临床试验,杂志文章
doi：10.1016/j.medengphy.2004.03.002
更新日期：2004-07-01 00:00:00
abstract：:Understanding hip osteoarthritis requires new investigational tools for quantitative studies of biophysical and biomechanical properties as well as for determination of structure. Three new protocols to study pathological changes in cartilage and to measure cartilage thickness in intact human hips are described using ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2019.08.003
更新日期：2019-11-01 00:00:00
abstract：:Segmentation of medical images is very important for clinical research and diagnosis, leading to a requirement for robust automatic methods. This paper reports on the combined use of a neural network (a multilayer perceptron, MLP) and active contour model ('snake') to segment structures in magnetic resonance (MR) imag...
journal_title：Medical engineering & physics
pub_type： 临床试验,杂志文章
doi：10.1016/s1350-4533(03)00137-1
更新日期：2004-01-01 00:00:00
abstract：:Children with severe physical disabilities often require a range of technological devices to aid them with the fundamental tasks carried out in everyday life. These tasks areas may include mobility, communication, environment control and computer access for education. The most efficient, and often the most cost-effect...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/1350-4533(94)90043-4
更新日期：1994-05-01 00:00:00
abstract：:In this study, we propose a new classification method for early differentiation of paroxysmal and persistent atrial fibrillation episodes, i.e. those which spontaneously or with external intervention will return to sinus rhythm within 7 days of onset from the ones where the arrhythmia is sustained for more than 7 days...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.10.013
更新日期：2017-01-01 00:00:00
abstract：:In this study, we applied multi-channel mechanomyographic (MMG) recordings in combination with linear and nonlinear analyses to investigate muscular and musculotendinous effects of high intensity eccentric exercise. Twelve accelerometers arranged in a 3 × 4 matrix over the dominant elbow muscles were used to detect MM...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.09.003
更新日期：2014-12-01 00:00:00
abstract：:In most computational fluid dynamic (CFD) analysis of the human lung, it has been assumed that the trachea and branches of the lung have smooth walls. In order to determine if this is a valid assumption, the effects of cartilage rings on airflow and particle deposition in the lungs was determined through conducting si...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2007.06.010
更新日期：2008-06-01 00:00:00
abstract：:Investigations into the effects of sterilization on a new biomechanical pressure sensor are necessary before contemplating in vivo use. Ten, designated Experimental, "K-Scan" digital pressure sensor arrays were sterilized with ethylene oxide gas (EtO), and their ability to accurately and reproducibly measure an applie...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(03)00119-x
更新日期：2003-11-01 00:00:00
abstract：:The BION (Bionic Neuron) is a single channel implantable neurostimulator of unique design that can be delivered by injection. The development of the BION injectable neurostimulators exemplifies a challenging, but well posed medical design problem addressed with a successful strategy for prioritizing and resolving the ...
journal_title：Medical engineering & physics
pub_type： 杂志文章,评审
doi：10.1016/j.medengphy.2010.08.010
更新日期：2011-01-01 00:00:00
abstract：:There is an increasing awareness among the populace of the need for regular health check-up to detect diseases in their early stages and thereby administer treatments in a timely fashion. However, commercially available physiological signal monitoring devices, which may offer clues on the onset of diseases, are time-c...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.04.011
更新日期：2013-02-01 00:00:00
abstract：:A ligamentous, nonlinear, sliding contact, three-dimensional finite element (FE) model of L2-L3 complex was developed to investigate the biomechanical effect of laminectomy with and without facetectomy. The L2-L3 FE model was validated against experimental study under various physiological loadings and found to match ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2003.11.006
更新日期：2004-04-01 00:00:00
abstract：:Based on an adaptive genetic fuzzy clustering algorithm, a derived fuzzy knowledge model is proposed for quantitatively estimating the systolic arterial pressure (SAP), heart rate (HR), and bispectral index (BIS) using 12 patients and it validates them according to pharmacological reasoning. Also, a genetic proportion...
journal_title：Medical engineering & physics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.medengphy.2005.04.023
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Verified and validated CT-based high-order finite element (FE) methods were developed that predict accurately the mechanical response of patient-specific intact femurs. Here we extend these capabilities to human femurs undergoing a total hip replacement using cemented prostheses. METHODS:A fresh-frozen huma...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.09.007
更新日期：2013-07-01 00:00:00
abstract：:The presented research positively evaluates the vocality of the cough sound by estimating the global cough fundamental frequency or pitch. The fundamental frequency was determined by autocorrelation analysis on both the original time-signal and the linear predicted time-signal. The experimental cough database was regi...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(02)00055-3
更新日期：2002-09-01 00:00:00
abstract：:We adopt the Ensemble Empirical Mode Decomposition (EEMD) method, with an appropriate thresholding on the Intrinsic Mode Functions (IMFs), to denoise the magnetocardiography (MCG) signal. To this end, we discuss the two associated problems that relate to: (i) the amplitude of noise added to the observed signal in the ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.06.023
更新日期：2014-10-01 00:00:00
abstract：:Biomechanical movement analysis in 3D requires estimation of joint centres in the lower extremities and this estimation is based on extrapolation from markers placed on anatomical landmarks. The purpose of the present study was to quantify the accuracy of three established set of equations and provide new improved equ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2015.07.001
更新日期：2015-10-01 00:00:00
abstract：:To determine the reliability, stability, validity and precision of a stereophotogrammetry (SP) system for use in quantifying the complex three-dimensional structure of the human torso, we performed assessments of the system using images of geometric solids and a human-form mannequin. Analysis of geometric solids revea...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2009.08.011
更新日期：2009-12-01 00:00:00
abstract：:Ultrasonic scalers are used in dentistry for removing mineralised plaque, known as calculus, from tooth surfaces. Though there is much information relating to the longitudinal vibrations of scaler probes, corresponding lateral data is limited. Understanding the lateral motion of ultrasonic probes is essential as, when...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2010.02.010
更新日期：2010-07-01 00:00:00
abstract：:Pedicle screw loosening is still observed in clinical practice. Therefore, the understanding of the interaction between screw and bone is evermore subject of research. However, complex relationships between screw design and anchorage are rarely examined. For this reason, it is investigated whether screw fixation is pr...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2020.03.001
更新日期：2020-05-01 00:00:00
abstract：:To better understand the mechanisms underlying distal radius fracture we have developed finite element models to predict radius bone strain and fracture strength under loading conditions simulating a fall. This study compares experimental surface strains and fracture loads of the distal radius with specimen-specific f...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.07.016
更新日期：2012-04-01 00:00:00
