Abstract：
:In this paper we investigate the extent to which variable porosity drug-eluting coatings can provide better control over drug release than coatings where the porosity is constant throughout. In particular, we aim to establish the potential benefits of replacing a single-layer with a two-layer coating of identical total thickness and initial drug mass. In our study, what distinguishes the layers (other than their individual thickness and initial drug loading) is the underlying microstructure, and in particular the effective porosity and the tortuosity of the material. We consider the effect on the drug release profile of varying the initial distribution of drug, the relative thickness of the layers and the relative resistance to diffusion offered by each layer's composition. Our results indicate that the contrast in properties of the two layers can be used as a means of better controlling the release, and that the quantity of drug delivered in the early stages can be modulated by varying the distribution of drug across the layers. We conclude that microstructural and loading differences between multi-layer variable porosity coatings can be used to tune the properties of the coating materials to obtain the desired drug release profile for a given application.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
McGinty S,King D,Pontrelli Gdoi
10.1016/j.medengphy.2017.04.006subject
Has Abstractpub_date
2017-07-01 00:00:00pages
51-60eissn
1350-4533issn
1873-4030pii
S1350-4533(17)30107-8journal_volume
45pub_type
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