Design of tissue engineering scaffolds based on hyperbolic surfaces: structural numerical evaluation.

Abstract:

:Tissue engineering represents a new field aiming at developing biological substitutes to restore, maintain, or improve tissue functions. In this approach, scaffolds provide a temporary mechanical and vascular support for tissue regeneration while tissue in-growth is being formed. These scaffolds must be biocompatible, biodegradable, with appropriate porosity, pore structure and distribution, and optimal vascularization with both surface and structural compatibility. The challenge is to establish a proper balance between porosity and mechanical performance of scaffolds. This work investigates the use of two different types of triple periodic minimal surfaces, Schwarz and Schoen, in order to design better biomimetic scaffolds with high surface-to-volume ratio, high porosity and good mechanical properties. The mechanical behaviour of these structures is assessed through the finite element method software Abaqus. The effect of two parametric parameters (thickness and surface radius) is also evaluated regarding its porosity and mechanical behaviour.

journal_name

Med Eng Phys

authors

Almeida HA,Bártolo PJ

doi

10.1016/j.medengphy.2014.05.006

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

1033-40

issue

8

eissn

1350-4533

issn

1873-4030

pii

S1350-4533(14)00121-0

journal_volume

36

pub_type

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