Abstract：
:The temperature at which collagen denatures from a triple helix to a random coil structure is a useful measure of the degree of crosslinking. A new multi-sample denaturation temperature tester (DTT) has been constructed for rapid determination of the collagen denaturation temperature of natural tissues and collagenous biomaterials. To validate the system, the denaturation temperatures measured for the DTT are compared with results from differential scanning calorimetry (DSC). Data are presented for bovine pericardium in three states with denaturation temperatures ranging from 68 to 85 degrees C: fresh, or crosslinked with glutaraldehyde or the epoxide reagent Denacol EX-512 poly (glycidyl ether). Denaturation temperatures measured by DTT were not significantly different from those measured by differential scanning calorimetry (DSC); however, DSC onset systematically occurred at a slightly lower temperature than that measured by DTT. This result, seen only for fresh tissue is in agreement with earlier experiments using hydrothermal isometric tension (HIT) testing. By contrast, DTT and DSC onset were identical for the exogenously crosslinked materials. Since the measured transition temperature was independent of initial load, this variable may be chosen to yield sharper force-temperature transitions with a given sample geometry. This instrument allows accurate assessment of collagen denaturation temperatures for multiple samples in a fraction of the time required by other methods.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Lee JM,Pereira CA,Abdulla D,Naimark WA,Crawford Idoi
10.1016/1350-4533(95)91882-hsubject
Has Abstractpub_date
1995-03-01 00:00:00pages
115-21issue
2eissn
1350-4533issn
1873-4030pii
135045339591882Hjournal_volume
17pub_type
杂志文章abstract：:The diagnosis of aseptic loosening of hip implants is often challenging. A vibrational analysis of the bone-implant interface could be an alternative method to analyze the fixation of endoprostheses. We assessed an innovative and new approach for excitation by using extracorporeal shockwaves in this study. In three ca...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.11.011
更新日期：2015-02-01 00:00:00
abstract：:The rehabilitation engineering community is working towards the development of robotic devices that can assist during gait training of patients suffering from neurologic injuries such as stroke and spinal cord injuries (SCI). The field of robot assisted treadmill training has rapidly evolved during the last decade. Th...
journal_title：Medical engineering & physics
pub_type： 杂志文章,评审
doi：10.1016/j.medengphy.2010.12.010
更新日期：2011-06-01 00:00:00
abstract：:The liquid ventilation (LV) technique was previously demonstrated to be a valuable alternative to ordinary gas ventilation, particularly for newborn patients with severely distressed lungs. This work describes a mathematical model of gas transfer phenomena occurring within the lungs of a preterm newborn baby ventilate...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(96)00041-0
更新日期：1997-03-01 00:00:00
abstract：:Kinematic parameters for 10 normal subjects and 10 patients with ankle arthrodesis are grouped using the fuzzy cluster paradigm. The features chosen for clustering are Euler angles of the sagittal plane in the hindfoot, the forefoot and combined hindfoot and forefoot joints. Gait patterns are identified using informat...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(01)00020-0
更新日期：2001-03-01 00:00:00
abstract：:Fetal movement is one index of fetal well-being. We designed and built a new recorder based on fetal movement acceleration measurement (FMAM). The FMAM recorder has a newly developed, capacitive acceleration sensor that can detect the oscillations of the maternal abdominal wall caused by fetal movements. In this study...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.09.001
更新日期：2012-06-01 00:00:00
abstract：:A method for leakage effect reduction by a modification of the classical spectra obtained Discrete Fourier Transform is proposed. The properties of the new method are investigated analytically and validated through synthesized signals, processed by the developed complete computational procedure. This combines the prop...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(97)00006-4
更新日期：1997-07-01 00:00:00
abstract：:Using an anaesthetized cat's central footpad pressed against an object as the model of a paralyzed human hand, a nerve signal recording system was developed to measure the effect of a group of consecutive slips between the footpad and the object. Electroneurographic (ENG) activity was recorded using a cuff electrode i...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2007.05.007
更新日期：2008-05-01 00:00:00
abstract：:This paper describes the application of probabilistic design methods to the analysis of the behaviour of an uncemented total hip replacement femoral component implanted in a proximal femur. Probabilistic methods allow variations in factors which control the behaviour of the implanted femur (the input parameters) to be...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2009.01.002
更新日期：2009-05-01 00:00:00
abstract：:Radiofrequency has established itself as a useful technique for managing cardiac arrhythmias and treating soft tissue tumors. However, despite its pervasive use, many of the biophysical principals needed to fully understand and optimize the radiofrequency ablation technique have not been explored. We have designed a t...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(02)00044-9
更新日期：2002-11-01 00:00:00
abstract：:Locking compression plates (LCPs) have been used to fix femoral shaft fractures. Previous studies have attempted to identify the best LCP screw positions and numbers to achieve the fixation stability. However, the determined screw positions and numbers were mainly based on the surgeons' experiences. The aim of this st...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2013.09.005
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To evaluate whether outcomes based on stopwatch time and power output (PO) over a 15m-overground wheelchair sprint test can be used to assess wheelchair-specific anaerobic work capacity, by studying their relationship with outcomes on a Wingate-based 30s-wheelchair ergometer sprint (WAnT). METHODS:Able-bodie...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.01.003
更新日期：2014-04-01 00:00:00
abstract：:Postural control deficits are the most disabling aspects of Parkinson's disease (PD), resulting in decreased mobility and functional independence. The aim of this study was to assess the postural control stability, revealed by variables based on the centre of pressure (CoP), in individuals with PD while performing a s...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2015.08.011
更新日期：2015-11-01 00:00:00
abstract：:A decrease in mobility, related to illness, trauma or ageing, negatively affects the quality of life of the rapidly growing elderly population. A promising solution to maintain this standard of living is powered wearable mobility assist devices. Although they have achieved technological breakthroughs in the last decad...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2020.03.008
更新日期：2020-06-01 00:00:00
abstract：:The paper described a limited part of the coagulation pathway, and in particular the inhibitory effects of activated protein C in the context of thrombin production. This is a computational modeling study with various assumption made of kinetic rates laws and their summation. The level of complexity and assumed parame...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2004.01.003
更新日期：2004-05-01 00:00:00
abstract：:Biomechanical movement analysis in 3D requires estimation of joint centres in the lower extremities and this estimation is based on extrapolation from markers placed on anatomical landmarks. The purpose of the present study was to quantify the accuracy of three established set of equations and provide new improved equ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2015.07.001
更新日期：2015-10-01 00:00:00
abstract：:We have developed a computer-based system to simulate a guidewire in blood vessels for surgical planning, intra-operative assistance, and to facilitate the design of new guidewires. In this study, we compared simulation results with experimental results for validation of the simulation system. First, we inserted a com...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.09.012
更新日期：2014-12-01 00:00:00
abstract：:This study tested the effectiveness of low-level laser therapy (LLLT) in preventing and/or treating osteoporotic trabecular bone. Mice were ovariectomized (OVX) to induce osteoporotic bone loss. The tibiae of eight OVX mice were treated for 5 days each week for 2 weeks by LLLT (660 nm, 3 J) using a minimally invasive ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.10.002
更新日期：2013-07-01 00:00:00
abstract：:Extensive research is ongoing in the field of orthoses/exoskeleton design for efficient lower limbs assistance. However, despite wearable devices reported to improve lower limb mobility, their structural impacts on whole-body vertical dynamics have not been investigated. This study introduced a model identification ap...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2020.04.005
更新日期：2020-06-01 00:00:00
abstract：:Inserting the distal locking screws is a challenging step of the intramedullary nailing procedures due to the nail deformation that makes the proximally mounted targeting systems ineffective. A pre-planning methodology is proposed, based on an analytical model of the nail-bone construct, to predict the nail deformatio...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2019.09.012
更新日期：2019-12-01 00:00:00
abstract：:Easy insertion of the implant and stable bone purchase is essential for an ideal dental implantation. At the implant tip, the cutting flutes and conical profile are respectively designed to reduce insertion resistance and facilitate the initial insertion. However, the tapered tip might reduce the self-tapping and bone...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.09.021
更新日期：2012-09-01 00:00:00
abstract：:Longitudinal anatomic mismatch (LAM) of stenting (i.e., a stenotic artery segment is not fully covered by a deployed stent) worsens the mechanical environment in the treated artery, which most likely is the cause for the associated high risks of restenosis, myocardial infarction and stent thrombosis. To probe the poss...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2017.06.010
更新日期：2017-10-01 00:00:00
abstract：:In vivo bone behaviour predictions with respect to altered loading conditions, implants, and endoprostheses are highly desirable to avoid untoward effects such as implant loosening and breakage. This knowledge does not relate only to the result but also to the mechanisms of bone adaptation and bone growth. Since bone ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/1350-4533(94)90014-0
更新日期：1994-01-01 00:00:00
abstract：:Sclerosis rim surrounding the necrotic area is commonly found in necrotic femoral head, but the biomechanical function of sclerosis rim has received relatively little attention. Little is known about the formation and natural history of sclerosis rim. In the present work, we assume that the necrotic change may trigger...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2015.09.005
更新日期：2015-12-01 00:00:00
abstract：:In this paper the biomechanical response of a novel dental preparation technique, referred to as the Anatomic-Functional-Geometry treatment (AFG), is investigated through a 3D nonlinear finite-element modelling approach. A comparative investigation against a standard technique employed in dental clinical practice is c...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2020.10.016
更新日期：2020-12-01 00:00:00
abstract：:The current strategy for the control of tuberculosis (TB) relies on early diagnosis, and smear microscopy is an essential component of the laboratory diagnosis of TB in most countries with a high prevalence of the disease. However, even simple smear microscopy examination is far from satisfactory because staining resu...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(02)00213-8
更新日期：2003-05-01 00:00:00
abstract：:The standard camera- and force plate-based set-up for motion analysis suffers from the disadvantage of being limited to laboratory settings. Since adaptive algorithms are able to learn the connection between known inputs and outputs and generalise this knowledge to unknown data, these algorithms can be used to leverag...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2020.10.001
更新日期：2020-12-01 00:00:00
abstract：:Small spaces make collision-free turns difficult for wheelchair users. Contrary to basic kinematic wheelchair modelling and not considered previously by engineers; when wheelchairs turn in small spaces, could lateral drift (sideways slipping) increase the risk of collisions with surrounding structures such as walls an...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2020.11.012
更新日期：2021-01-01 00:00:00
abstract：:Biomagnetic investigations in basic physiological research using animals require measurement devices different from commercial biomagnetometers used in human investigations. Two major problems have to be tackled in the design of such biomagnetometers. First, the spatial sampling needs to be much higher. Second, the di...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(99)00088-0
更新日期：1999-10-01 00:00:00
abstract：:An 'instantaneous' optimal filter is presented for improving the signal-to-noise ratio in averaged electrocardiograms (ECGs). The filter design is based on a simple model that accounts for correlation across the ensemble of beats but ignores correlation in time. Another property of the model is that the noise level is...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(96)00069-0
更新日期：1997-04-01 00:00:00
abstract：:The spectral analysis of crackles sounds has been carried out based on the assumption that they are stationary signals, and the majority of the work on the crackles was accomplished before the publication of the Computerized Respiratory Sound Analysis (CORSA) guidelines. This works characterizes crackles acquired from...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.06.009
更新日期：2013-04-01 00:00:00
