Abstract：
:Laser Ablation (LA) is a minimally-invasive procedure for tumor treatment. LA outcomes depend on the heat distribution inside tissues and require accurate temperature measurement during the procedure. Magnetic resonance imaging (MRI) allows a non-invasive and three-dimensional thermometry of the organ undergoing LA. In this study, the temperature distribution within two swine pancreases and three swine livers undergoing LA (Nd:YAG, power: 2 W, treatment time: 4 min) was monitored by a 1.5-T MR scanner, utilizing two T1-weighted sequences (IRTF and SRTF). The signal intensity in four regions of interest, placed at different distances from the laser applicator, was related to temperature variations monitored in the same regions by twelve fiber Bragg grating sensors. The relationship between the signal intensity and temperature increase was calculated to obtain the calibration curve and to evaluate accuracy, sensibility and precision of each sequence. This is the first study of MR-based thermometry during LA on pancreas. More specifically, the IRTF sequence provides the highest temperature sensitivity in both liver (1.8 ± 0.2 °C(-1)) and pancreas (1.8 ± 0.5 °C(-1)) and the lowest precision and accuracy. SRTF sequence on pancreas presents the highest accuracy and precision (MODSFRT = -0.1 °C and LOASFRT = [-2.3; 2.1] °C).
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Allegretti G,Saccomandi P,Giurazza F,Caponero MA,Frauenfelder G,Di Matteo FM,Beomonte Zobel B,Silvestri S,Schena Edoi
10.1016/j.medengphy.2015.04.001subject
Has Abstractpub_date
2015-07-01 00:00:00pages
631-41issue
7eissn
1350-4533issn
1873-4030pii
S1350-4533(15)00096-Xjournal_volume
37pub_type
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