Abstract：
:Single-photon emission computed tomography (SPECT) of dopamine transporters with (99m)Tc-TRODAT-1 has recently been proposed to offer valuable information for the diagnosis of Parkinson's disease (PD). Furthermore, High-intensity focused ultrasound (HIFU) is a newly developed technique in which the energy of ultrasound wave is directed to a focused spot for the purpose treatment of PD. This study presents a diagnosis and image-guided system using HIFU to treat the mouse with PD under a designed stereotactic frame. The system comprises two key components: an automatic atlas-based SPECT/MRI image registration module for diagnosis and a stereotactic CT-guided module for HIFU treatment. The SPECT/MR image registration here is important in the non-invasive examination of the dopamine concentration in vivo. From the experimental results, the image registration module proves to have comparable performance to that derived from manual drawing by experts. In addition, the stereotactic CT-guided module achieved a positioning accuracy to within 2mm on the average, which is acceptable for the purpose of HIFU treatment.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Lee JD,Huang CH,Yang ST,Chu YH,Shieh YY,Chen JW,Lin KJdoi
10.1016/j.medengphy.2012.01.006subject
Has Abstractpub_date
2013-02-01 00:00:00pages
222-30issue
2eissn
1350-4533issn
1873-4030pii
S1350-4533(12)00009-4journal_volume
35pub_type
杂志文章abstract：:In the fields of medicine and biomechanics, MEMS accelerometers are increasingly used to perform activity recognition by directly measuring acceleration; to calculate speed and position by numerical integration of the signal; or to estimate the orientation of body parts in combination with gyroscopes. For some of thes...
journal_title：Medical engineering & physics
pub_type： 杂志文章,评审
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abstract：:In this study we integrated between confocal-based cell-specific finite element (FE) modeling and Virtual Cell (VC) transport simulations in order to determine trends of relationship between externally applied compressive deformations and build-up rates of oxygen in myoblast cells, and to further test how mild culture...
journal_title：Medical engineering & physics
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更新日期：2011-11-01 00:00:00
abstract：:A novel multi-scale simulation method developed to describe mesoscale phenomena occurring in biofluidic devices is presented. The approach combines the macro-scale modelling of the carrier fluid and the micro-scale description of the transported macromolecules or compounds. Application of the approach is demonstrated ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2010.08.003
更新日期：2011-09-01 00:00:00
abstract：:Medical imaging and clinical studies have proven that the heart pumps by means of minor outer volume changes and back-and-forth longitudinal movements in the atrioventricular (AV) region. The magnitude of AV-plane displacement has also shown to be a reliable index for diagnosis of heart failure. Despite this, AV-plane...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.11.002
更新日期：2015-01-01 00:00:00
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journal_title：Medical engineering & physics
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doi：10.1016/j.medengphy.2013.03.005
更新日期：2013-09-01 00:00:00
abstract：:Metal plates are commonly used in the operative treatment of bone fractures. Rigid metal plates stabilize the fracture site, maintain good contact between bone fragments and allow early weight bearing and patient mobility. However, treatment with rigid metal plates can cause localized bone atrophy due to stress-shield...
journal_title：Medical engineering & physics
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doi：10.1016/1350-4533(95)00041-0
更新日期：1996-04-01 00:00:00
abstract：OBJECTIVE:Joint space narrowing is an important feature of progressive joint damage and functional impairment in rheumatoid arthritis (RA). Methods to provide a continuous measurement of joint space width have not been adopted in research or clinical settings. High-resolution peripheral quantitative computed tomography...
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pub_type： 杂志文章
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更新日期：2013-10-01 00:00:00
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更新日期：2018-12-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2013.09.007
更新日期：2014-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.medengphy.2007.09.003
更新日期：2008-09-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2013.09.003
更新日期：2014-01-01 00:00:00
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更新日期：2019-09-01 00:00:00
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更新日期：2016-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.05.011
更新日期：2016-08-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.07.017
更新日期：2013-06-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2005.11.005
更新日期：2006-10-01 00:00:00
abstract：:A small and wireless device that can capture the temporal pattern of perspiration by a novel structure of water vapor collection combined with reusable desiccant has been developed. The novel device consists of a small cylindrical case with a temperature/relative humidity sensor, battery-driven data logger, and silica...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2015.12.009
更新日期：2016-04-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2004.09.001
更新日期：2005-01-01 00:00:00
abstract：:Zygomatic implant technology has been regarded as an alternative treatment to massive grafting surgery in the severe atrophic maxillary. Nowadays, the assistant method with a real-time surgical navigation has been applied to reduce the risks of zygomatic implant placement. However, the accuracy of the complex operatio...
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更新日期：2020-01-01 00:00:00
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doi：10.1016/j.medengphy.2008.11.010
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abstract：OBJECTIVE:A novel methodology has been developed to evaluate regional alterations in arterial wall material properties with induced atheroma in an animal model. METHODS:Atheromatous lesions (fatty, fibro-fatty, and fibrous) were induced in the carotid arteries of a Yucatan miniswine model by endothelial cell denudatio...
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更新日期：2005-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.08.022
更新日期：2013-07-01 00:00:00
abstract：:A flow model utilizing an irrotational, inviscid algorithm of vortex-ring elements simulating the leaflets and source/sink elements simulating the aortic root coupled with a boundary layer model has been developed to model the internal flow phenomena of bi-leaflet mechanical heart valves implanted in the aortic root. ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/1350-4533(95)00075-5
更新日期：1996-09-01 00:00:00
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doi：10.1016/j.medengphy.2010.04.002
更新日期：2010-06-01 00:00:00
abstract：:The role and effect of preserved antegrade pulmonary blood flow (APBF) at the time of bidirectional cavopulmonary anastomosis (BCPA) in the management of single-ventricle physiology is controversial. We investigated the influence of APBF on the fluid dynamics of BCPA connection using computational fluid dynamics (CFD)...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2008.07.004
更新日期：2009-03-01 00:00:00
abstract：:Currently, a number of studies focus on the study and design of new healthcare technologies to improve elderly health and quality of life. Taking advantage of the popularity, portability, and inherent technology of smartphones, we present an emergency application for smartphones, designated as knock-to-panic (KTP). Th...
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doi：10.1016/j.medengphy.2016.05.002
更新日期：2016-09-01 00:00:00
abstract：:The investigation of patellar tendon reflex involves development of a reflex hammer holder, kinematic data collection and analysis of patellar reflex responses using motion analysis techniques. The main aim of this research is to explore alternative means of assessing reflexes as a part of routine clinical diagnosis. ...
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pub_type： 临床试验,杂志文章
doi：10.1016/j.medengphy.2010.11.002
更新日期：2011-05-01 00:00:00
abstract：:The spectral local F-test has been applied for detecting evoked responses to rhythmic stimulation that are embedded in the ongoing electroencephalogram (EEG). Based on the sampling distribution of a flat spectrum at the neighbourhood of the stimulation frequency, spectral peaks in an EEG signal that are due to the sti...
journal_title：Medical engineering & physics
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doi：10.1016/j.medengphy.2017.06.032
更新日期：2017-10-01 00:00:00
