Abstract：
:A novel multi-scale simulation method developed to describe mesoscale phenomena occurring in biofluidic devices is presented. The approach combines the macro-scale modelling of the carrier fluid and the micro-scale description of the transported macromolecules or compounds. Application of the approach is demonstrated through mesoscale simulations of DNA molecules. The investigated phenomena include elastic relaxation of dsDNA molecules and migration of ssDNA molecules in a microchannel flow. The results of the first study demonstrate that the elastic behaviour of the DNA molecules can be captured sucessfully. The second study proves that the migration of ssDNA in pressure-driven microchannel flows can be explained by the hydrodynamic interaction with the carrier liquid.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Benke M,Shapiro E,Drikakis Ddoi
10.1016/j.medengphy.2010.08.003subject
Has Abstractpub_date
2011-09-01 00:00:00pages
883-6issue
7eissn
1350-4533issn
1873-4030pii
S1350-4533(10)00172-4journal_volume
33pub_type
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