Abstract：
OBJECTIVE:A novel methodology has been developed to evaluate regional alterations in arterial wall material properties with induced atheroma in an animal model. METHODS:Atheromatous lesions (fatty, fibro-fatty, and fibrous) were induced in the carotid arteries of a Yucatan miniswine model by endothelial cell denudation and high cholesterol diet. The images at base line and 8 weeks after denudation were obtained using intravascular ultrasound (IVUS) imaging along with hemodynamic data. Finite element analysis (FEA) along with optimization was employed to assess regional alterations in elastic modulus in the presence of atheroma confirmed by histology. RESULTS:In animals with 8 weeks of induced atherosclerosis, the elastic modulus increased-(elastic modulus-all values x 10(4) Pa, mean+/-S.D.) normal elements (9.34+/-0.36) compared to abnormal elements (9.52+/-0.36) (p<0.05 versus normal elements). Wall thickness increased with atheroma formation. These data demonstrate stiffening vascular wall elastic modulus with lesion progression. This is different from the behavior of femoral arteries, where the elastic modulus decreases with early stages of atheroma development followed by an increase as lesions progress. CONCLUSIONS:This methodology permits determination of areas with early atheroma development, follow atheroma progression, and potentially evaluate interventions aimed at decreasing atheroma load and normalizing vascular material properties.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Nagaraj A,Kim H,Hamilton AJ,Mun JH,Smulevitz B,Kane BJ,Yan LL,Roth SI,McPherson DD,Chandran KBdoi
10.1016/j.medengphy.2004.09.014subject
Has Abstractpub_date
2005-03-01 00:00:00pages
147-56issue
2eissn
1350-4533issn
1873-4030pii
S1350-4533(04)00177-8journal_volume
27pub_type
杂志文章abstract：OBJECTIVE:To evaluate whether outcomes based on stopwatch time and power output (PO) over a 15m-overground wheelchair sprint test can be used to assess wheelchair-specific anaerobic work capacity, by studying their relationship with outcomes on a Wingate-based 30s-wheelchair ergometer sprint (WAnT). METHODS:Able-bodie...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.01.003
更新日期：2014-04-01 00:00:00
abstract：:Characterising circulatory dysfunction and choosing a suitable treatment is often difficult and time consuming, and can result in a deterioration in patient condition, or unsuitable therapy choices. A stable minimal model of the human cardiovascular system (CVS) is developed with the ultimate specific aim of assisting...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2003.10.001
更新日期：2004-03-01 00:00:00
abstract：:Although the precise causes of Sudden Infant Death Syndrome (SIDS) are still unclear there is evidence to suggest that hypoxaemia may be a contributory factor. Transcutaneous oxygen monitors can be used but are unsatisfactory for young babies in the home. As an alternative approach, respiratory patterns can be studied...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/1350-4533(94)90005-1
更新日期：1994-01-01 00:00:00
abstract：:A novel multi-scale simulation method developed to describe mesoscale phenomena occurring in biofluidic devices is presented. The approach combines the macro-scale modelling of the carrier fluid and the micro-scale description of the transported macromolecules or compounds. Application of the approach is demonstrated ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2010.08.003
更新日期：2011-09-01 00:00:00
abstract：:The incudostapedial joint (ISJ) is a synovial joint connecting the incus and stapes in the middle ear. Mechanical properties of the ISJ directly affect sound transmission from the tympanic membrane to the cochlea. However, how ISJ properties change with frequency has not been investigated. In this paper, we report the...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2018.02.006
更新日期：2018-04-01 00:00:00
abstract：:Stent implantation has become a widely accepted endovascular intervention for the treatment of stenosed arteries. This minimally invasive technique has shown excellent results in unbranched arteries. However, stenting bifurcation lesions remains a challenge in coronary intervention as it is associated with a lower suc...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2008.11.013
更新日期：2009-05-01 00:00:00
abstract：:The diagnosis of aseptic loosening of hip implants is often challenging. A vibrational analysis of the bone-implant interface could be an alternative method to analyze the fixation of endoprostheses. We assessed an innovative and new approach for excitation by using extracorporeal shockwaves in this study. In three ca...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.11.011
更新日期：2015-02-01 00:00:00
abstract：:The majority of the eye models developed in the late 90s and early 00s considers only heat conduction inside the eye. This assumption is not entirely correct, since the anterior and posterior chambers are filled aqueous humor (AH) that is constantly in motion due to thermally-induced buoyancy. In this paper, a three-d...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.05.011
更新日期：2016-08-01 00:00:00
abstract：:This paper reports on the findings of an extensive survey investigating practising design engineers' perceptions of new product development within the UK medical device industry. The design activity recorded was predominantly the small-scale development of low volume products. Explicit formal procedures were rarely us...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(96)00021-5
更新日期：1996-12-01 00:00:00
abstract：:Post-myocardial infarction remodeling process is known to alter the mechanical properties of the heart. Biomechanical parameters, such as tissue stiffness and contractility, would be useful for clinicians to better assess the severity of the diseased heart. However, these parameters are difficult to obtain in the curr...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2020.09.003
更新日期：2020-11-01 00:00:00
abstract：:Fetal movement is one index of fetal well-being. We designed and built a new recorder based on fetal movement acceleration measurement (FMAM). The FMAM recorder has a newly developed, capacitive acceleration sensor that can detect the oscillations of the maternal abdominal wall caused by fetal movements. In this study...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.09.001
更新日期：2012-06-01 00:00:00
abstract：:Understanding the load mechanics of orthopaedic implants is important to be able to predict their behaviour in-vivo. Much research, both mechanical and clinical, has been carried out on hip and knee implants, but less has been written about the mechanics of wrist implants. In this paper, the load mechanics of the Univ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.02.008
更新日期：2016-06-01 00:00:00
abstract：:Heart rate variability (HRV) is a non-invasive alternative to analyze the role of the autonomic nervous system (ANS) on heart functioning. Many tools have been developed to analyze collected cardiac data. Among them, the Central Tendency Measure (CTM) is a quantitative method for variability analysis of RR intervals. ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2019.09.024
更新日期：2019-12-01 00:00:00
abstract：:A method for assessment and second-order polynomial detrending of signals containing periodic components is proposed. The analytically derived properties of this method are validated with synthesized signals, processed by the computational procedure developed. It is shown that, in addition to accurate detrending, the ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(98)00077-0
更新日期：1998-11-01 00:00:00
abstract：:Musculoskeletal simulations are an essential tool for studying functional implications of pathologies and of potential surgical outcomes, e.g., for the complex shoulder anatomy. Most shoulder models rely on line-segment approximation of muscles with potential limitations. Comprehensive shoulder models based on continu...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2020.04.010
更新日期：2020-08-01 00:00:00
abstract：:In this paper a self-opening intrafascicular neural interface (SELINE) has been modeled using both a theoretical approach and a Finite Element (FE) analysis. This innovative self opening interface has several potential advantages such as: higher selectivity due to its three-dimensional structure and efficient anchorag...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.06.001
更新日期：2011-12-01 00:00:00
abstract：:The high rate of fixation failure in osteoporotic proximal humerus fractures indicate the need for improved solutions. Computer simulations may help to overcome the limitations of the gold standard biomechanical testing in evaluating the performance of new implants and enhance the effectivity and outcome of the design...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2018.04.011
更新日期：2018-07-01 00:00:00
abstract：:Previous studies investigating thrombus formation have not focused on the physical interaction between red blood cells (RBCs) and thrombus, although they have been speculated that some pathological conditions such as microangiopathic hemolytic anemia (MAHA) stem from interactions between RBCs and thrombi. In this stud...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.01.003
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:To illustrate (a) whether a statistical shape model (SSM) augmented with anatomical landmark set(s) performs better fitting and provides improved clinical relevance over non-augmented SSM and (b) which anatomical landmark set provides the best augmentation strategy for predicting the glenoid region of the sca...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2019.11.007
更新日期：2020-02-01 00:00:00
abstract：:Failures of proximal femoral nails that treat unstable femoral fractures have been reported. In this communication, a finite element model to include a proximal femoral nail within a fractured femur was used to carry out preliminary investigations into configurations of single or double lag screws. The effects of the ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(00)00081-3
更新日期：2000-11-01 00:00:00
abstract：:Accurate models of bone shapes are essential for orthopaedic reconstructions. The commonly used methods of using the contralateral side requires an intact bone and anatomical symmetry. Recent studies have shown that statistical shape and appearance models (SSAMs) as an alternative can predict accurate geometric models...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2019.03.007
更新日期：2019-05-01 00:00:00
abstract：:The complexity, nonlinearity and nonstationarity of the cardiovascular system typically defy comprehensive and deterministic mathematical modeling, except from a statistical perspective. Living systems are governed by numerous, continuously changing, interacting variables in the presence of noise. Cardiovascular signa...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(01)00112-6
更新日期：2002-01-01 00:00:00
abstract：:In stark contrast to the inspiring functionality of the natural hand, limitations of current upper limb prostheses stemming from marginal feedback control, challenges of mechanical design, and lack of sensory capacity, are well-established. This paper provides a critical review of current sensory systems and the poten...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2005.09.009
更新日期：2006-07-01 00:00:00
abstract：:In our previous studies, we have introduced model-based "functional biomarkers" or "physiomarkers" of cerebral hemodynamics that hold promise for improved diagnosis of early-stage Alzheimer's disease (AD). The advocated methodology utilizes subject-specific data-based dynamic nonlinear models of cerebral hemodynamics ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.02.025
更新日期：2014-05-01 00:00:00
abstract：:A decrease in bone density at the hip or spine has been shown to increase the risk of fracture. A limitation of the bone mineral density (BMD) measurement is that it provides only a measure of a bone sample's average density when projected onto a 2D surface. Effectively, what determines bone fracture is whether an app...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.08.008
更新日期：2012-05-01 00:00:00
abstract：:Large Eddy Simulation (LES) is performed to study the physiological pulsatile transition-to-turbulent non-Newtonian blood flow through a 3D model of arterial stenosis by using five different blood viscosity models: (i) Power-law, (ii) Carreau, (iii) Quemada, (iv) Cross and (v) modified-Casson. The computational domain...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.11.013
更新日期：2012-10-01 00:00:00
abstract：:Quantification in clinical, diagnostic electromyography (EMG) currently includes motor unit action potential (MUAP) analysis and interference pattern analysis. Early efforts to examine the frequency/power spectra of the interference pattern showed modest value but the technique was not developed further. This paper re...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.07.017
更新日期：2012-03-01 00:00:00
abstract：:Our main goal was to test various impedance methods for measuring body composition in adolescents with anorexia nervosa (AN) during refeeding therapy. A specific objective was to compare the information provided by a foot-to-foot impedancemeter (FFI) with that supplied by a medical multifrequency impedancemeter and by...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2007.09.005
更新日期：2008-07-01 00:00:00
abstract：:Recently, surgeons have begun to treat serious congenital craniofacial deformities including craniosynostoses with mechanical devices that gradually distract the skull. As a prospective means of treatment planning for such complex deformities, FE models derived from routine preoperative CT scans (CT/FEA) would provide...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(98)00053-8
更新日期：1998-11-01 00:00:00
abstract：:Pulse transit time (PTT) has emerged over the recent decades as a simple and non-invasive measure to quantify inspiratory effort changes in adults with sleep disordered breathing (SDB). Hence, this shows promise to be an effective screening tool for the paediatrics. However, little is known about its utility and suita...
journal_title：Medical engineering & physics
pub_type： 杂志文章,评审
doi：10.1016/j.medengphy.2006.01.006
更新日期：2007-01-01 00:00:00
