Abstract：
:The purpose of this review paper is to summarize the current knowledge on cell-scale mechanically-inflicted deformation-damage, which is at the frontier of cell mechanobiology and biomechanics science, specifically in the context of chronic wounds. The dynamics of the mechanostructure of cells and particularly, the damage occurring to the cytoskeleton and plasma-membrane when cells are chronically deformed (as in a weight-bearing static posture) is correlated to formation of the most common chronic wounds and injuries, such as pressure ulcers (injuries). The first occurrence is microscopic injury which onsets as damage in individual cells and then progresses macroscopically to the tissue-scale. Here, we specifically focus on sub-catastrophic and catastrophic damage to cells that can result from mechanical loads that are delivered statically or at physiological rates; this results in apoptosis at prolonged times or necrosis, rapidly. We start by providing a basic background of cell mechanics and dynamics, focusing on the plasma-membrane and the cytoskeleton, and discuss approaches to apply and estimate deformations in cells. We then consider the effects of different levels of mechanical loads, i.e. low, high and intermediate, and describe the expected damage in terms of time-scales of application and in terms of cell response, providing experimental examples where available. Finally, we review different theoretical and computational modeling approaches that have been used to describe cell responses to sustained deformation. We highlight the insights that those models provide to explain, for example, experimentally observed variabilities in cell damage and death under loading.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Gefen A,Weihs Ddoi
10.1016/j.medengphy.2016.05.014subject
Has Abstractpub_date
2016-09-01 00:00:00pages
828-33issue
9eissn
1350-4533issn
1873-4030pii
S1350-4533(16)30111-4journal_volume
38pub_type
杂志文章,评审abstract：:The second-order difference plot, as a modified Poincaré plot, is one of the important approaches for assessing the dynamics of heart rate variability. However, corresponding quantitative analysis methods are relatively limited. Based on the second-order difference plot, we propose a novel method, called the multi-sca...
journal_title：Medical engineering & physics
pub_type： 杂志文章
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journal_title：Medical engineering & physics
pub_type： 杂志文章
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journal_title：Medical engineering & physics
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journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.05.002
更新日期：2016-09-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
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journal_title：Medical engineering & physics
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pub_type： 临床试验,杂志文章
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journal_title：Medical engineering & physics
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章,评审
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journal_title：Medical engineering & physics
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更新日期：2011-01-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2019.11.007
更新日期：2020-02-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 临床试验,杂志文章
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更新日期：2005-07-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.08.017
更新日期：2013-07-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2008.02.009
更新日期：2008-11-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
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更新日期：2014-09-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2008.11.013
更新日期：2009-05-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
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更新日期：2000-01-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.05.006
更新日期：2014-08-01 00:00:00
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更新日期：2014-01-01 00:00:00
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更新日期：2014-11-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
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更新日期：2006-09-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
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journal_title：Medical engineering & physics
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更新日期：1997-12-01 00:00:00
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更新日期：1996-12-01 00:00:00
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journal_title：Medical engineering & physics
pub_type： 杂志文章,随机对照试验
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更新日期：2006-03-01 00:00:00
abstract：:Zygomatic implant technology has been regarded as an alternative treatment to massive grafting surgery in the severe atrophic maxillary. Nowadays, the assistant method with a real-time surgical navigation has been applied to reduce the risks of zygomatic implant placement. However, the accuracy of the complex operatio...
journal_title：Medical engineering & physics
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
