Abstract：
:A DNA electrochemical biosensor is an integrated receptor-transducer device. The most important step in the development and manufacture of a sensitive DNA-biosensor for the detection of DNA-drug interactions is the immobilization procedure of the nucleic acid probe on the transducer surface. Magnetic A/C Mode atomic force microscopy (MAC Mode AFM) images in air were used to characterize two different procedures for immobilising nanoscale double-stranded DNA (dsDNA) surface films on carbon electrodes. Thin film dsDNA layers presented holes in the dsDNA film that left parts of the electrode surface uncovered while thicker films showed a uniform and complete coverage of the electrode. These two procedures for preparing dsDNA-biosensors were used to study the influence of reactive oxygen species (ROS) in the mechanism of DNA damage by quercetin, a flavonoid, and adriamycin, an anthracycline anticancer drug. The study of quercetin-DNA interactions in the presence of Cu(II) ions indicated that the formation of a quercetin-Cu(II) complex leads to the formation of ROS necessary to react with DNA, disrupting the helix and causing the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo). Reduced adriamycin radicals are able to directly cause oxidative damage to DNA, generating 8-oxodGuo and ROS are not directly involved in this genomic mutagenic lesion.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Oliveira-Brett AM,Paquim AM,Diculescu VC,Piedade JAdoi
10.1016/j.medengphy.2006.05.009subject
Has Abstractpub_date
2006-12-01 00:00:00pages
963-70issue
10eissn
1350-4533issn
1873-4030pii
S1350-4533(06)00097-Xjournal_volume
28pub_type
杂志文章abstract：:Subject-specific FE-models of human long bones have to predict mechanical parameters with sufficient accuracy to be applicable in a clinical setting. One of the main aspects in subject-specific FE-models of bones regarding accuracy is the modeling of the material inhomogeneity. The goal of this study was therefore to ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.08.022
更新日期：2013-07-01 00:00:00
abstract：:Tissue engineering represents a new field aiming at developing biological substitutes to restore, maintain, or improve tissue functions. In this approach, scaffolds provide a temporary mechanical and vascular support for tissue regeneration while tissue in-growth is being formed. These scaffolds must be biocompatible,...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.05.006
更新日期：2014-08-01 00:00:00
abstract：:Rapid fluid administration is the cornerstone of successful trauma resuscitation of patients in a state of shock. Intravenous (IV) fluid delivery is a physical intrusion into a vein which results in a complex interaction between the rigid catheter and the compliant vein. We present an experimental model of IV infusion...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(00)00046-1
更新日期：2000-07-01 00:00:00
abstract：:Understanding morphological features that characterize normal hip joint is critical and necessary for a more comprehensive definition of pathological presentations, such as femoroacetabular impingement and hip dysplasia. Based on anatomical observations that articular surfaces of synovial joints are better represented...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2018.07.001
更新日期：2018-09-01 00:00:00
abstract：:In our previous studies, we have introduced model-based "functional biomarkers" or "physiomarkers" of cerebral hemodynamics that hold promise for improved diagnosis of early-stage Alzheimer's disease (AD). The advocated methodology utilizes subject-specific data-based dynamic nonlinear models of cerebral hemodynamics ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.02.025
更新日期：2014-05-01 00:00:00
abstract：:Unlike primary stability of coated cementless implants, their secondary stability has been poorly studied. This paper considers some theoretical aspects of the secondary stability of a coated cementless hip implant in a human femur. The bone is separated from the implant by a thin layer of microscopic peaks and trough...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(03)00099-7
更新日期：2003-12-01 00:00:00
abstract：:Locking compression plates (LCPs) have been used to fix femoral shaft fractures. Previous studies have attempted to identify the best LCP screw positions and numbers to achieve the fixation stability. However, the determined screw positions and numbers were mainly based on the surgeons' experiences. The aim of this st...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2013.09.005
更新日期：2014-01-01 00:00:00
abstract：:To better understand the mechanisms underlying distal radius fracture we have developed finite element models to predict radius bone strain and fracture strength under loading conditions simulating a fall. This study compares experimental surface strains and fracture loads of the distal radius with specimen-specific f...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.07.016
更新日期：2012-04-01 00:00:00
abstract：:Quantifying the risk of falling (falls risk) would be helpful in treating people with gait disorders. The gait sensitivity norm (GSN) is a stability measure that correlates well to risk of falling in passive dynamic walkers but has not been evaluated on humans or human-like walking models. We assessed the correlation ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2013.03.018
更新日期：2013-10-01 00:00:00
abstract：:Understanding the load mechanics of orthopaedic implants is important to be able to predict their behaviour in-vivo. Much research, both mechanical and clinical, has been carried out on hip and knee implants, but less has been written about the mechanics of wrist implants. In this paper, the load mechanics of the Univ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.02.008
更新日期：2016-06-01 00:00:00
abstract：:The incudostapedial joint (ISJ) is a synovial joint connecting the incus and stapes in the middle ear. Mechanical properties of the ISJ directly affect sound transmission from the tympanic membrane to the cochlea. However, how ISJ properties change with frequency has not been investigated. In this paper, we report the...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2018.02.006
更新日期：2018-04-01 00:00:00
abstract：:The strains developed on the surface of a femur with and without an implanted femoral hip replacement were investigated using holographic interferometry (HI). Interferometric fringe data from the four aspects of the loaded femur were quantified and the resulting curvature calculated. Curvature was related to the strai...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(98)00003-4
更新日期：1998-03-01 00:00:00
abstract：:Investigations of compressive frequency, duty cycle, or waveform during CPR are typically rooted in animal research or computer simulations. Our goal was to generate a mechanical model incorporating alternate stiffness settings and an integrated blood flow system, enabling defined, reproducible comparisons of CPR effi...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2017.02.005
更新日期：2017-05-01 00:00:00
abstract：:Knowledge about the human skin mechanical properties is essential in several domains, particularly for dermatology, cosmetic or to detect some cutaneous pathology. This study proposes a new method to determine the human skin mechanical properties in vivo using the indentation test. Usually, the skin mechanical paramet...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2007.06.011
更新日期：2008-06-01 00:00:00
abstract：:An ambulatory monitoring system has been developed to measure the weight-bearing achieved by a patient on their fractured leg. The system is lightweight, portable, and can monitor weight-bearing continuously over an extended period of time. In addition to mean weight-bearing, the system can also determine temporal par...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(98)00061-7
更新日期：1998-10-01 00:00:00
abstract：:Somatosensory evoked potential (SEP) testing has been widely applied to diagnosis of various neurological disorders. However, SEP recorded using surface electrodes is buried in noises, which makes the signal-to-noise ratio (SNR) very poor. Conventional averaging method usually requires up to thousands of raw SEP input...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2004.09.007
更新日期：2005-04-01 00:00:00
abstract：:Currently, the study of ion composition and performance in human biofluids plays an important role in biomedical engineering research and technology. This field may become universal for human diagnostics; it allows early detection of different diseases in humans by measuring changes in ion behaviour in human biofluids...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.04.007
更新日期：2011-11-01 00:00:00
abstract：:The temperature at which collagen denatures from a triple helix to a random coil structure is a useful measure of the degree of crosslinking. A new multi-sample denaturation temperature tester (DTT) has been constructed for rapid determination of the collagen denaturation temperature of natural tissues and collagenous...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/1350-4533(95)91882-h
更新日期：1995-03-01 00:00:00
abstract：INTRODUCTION:This study compared the initial viscoelastic properties of a segmental tibial defect stabilized with intramedullary nailing and impaction bone grafting to that of a transverse fracture stabilized with intramedullary nailing. MATERIALS AND METHODS:Seven sheep tibiae were tested in compression (1000N), bend...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2013.09.003
更新日期：2014-01-01 00:00:00
abstract：:The loads between adjacent vertebrae can be generalised as a single spatial force acting at the intervertebral centre of reaction. The exact position in vivo is unknown. However, in rigid body musculoskeletal models that simulate upright standing, the position is generally assumed to be located at the discs' centres o...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2015.12.003
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:To evaluate whether outcomes based on stopwatch time and power output (PO) over a 15m-overground wheelchair sprint test can be used to assess wheelchair-specific anaerobic work capacity, by studying their relationship with outcomes on a Wingate-based 30s-wheelchair ergometer sprint (WAnT). METHODS:Able-bodie...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.01.003
更新日期：2014-04-01 00:00:00
abstract：:Pulse transit time (PTT) has emerged over the recent decades as a simple and non-invasive measure to quantify inspiratory effort changes in adults with sleep disordered breathing (SDB). Hence, this shows promise to be an effective screening tool for the paediatrics. However, little is known about its utility and suita...
journal_title：Medical engineering & physics
pub_type： 杂志文章,评审
doi：10.1016/j.medengphy.2006.01.006
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVE:To illustrate (a) whether a statistical shape model (SSM) augmented with anatomical landmark set(s) performs better fitting and provides improved clinical relevance over non-augmented SSM and (b) which anatomical landmark set provides the best augmentation strategy for predicting the glenoid region of the sca...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2019.11.007
更新日期：2020-02-01 00:00:00
abstract：:Computational fluid dynamics (CFD) simulations quantifying thoracic aortic flow patterns have not included disturbances from the aortic valve (AoV). 80% of patients with aortic coarctation (CoA) have a bicuspid aortic valve (BAV) which may cause adverse flow patterns contributing to morbidity. Our objectives were to d...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.07.015
更新日期：2013-06-01 00:00:00
abstract：:Intradialytic hypotension (IDH) is a major complication during hemodialysis treatment, and therefore it is highly desirable to identify, at an early stage during treatment, whether the patient is prone to IDH. Heart rate variability (HRV), blood pressure variability (BPV) and baroreflex sensitivity (BRS) were analyzed...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2015.10.003
更新日期：2015-12-01 00:00:00
abstract：:The BION (Bionic Neuron) is a single channel implantable neurostimulator of unique design that can be delivered by injection. The development of the BION injectable neurostimulators exemplifies a challenging, but well posed medical design problem addressed with a successful strategy for prioritizing and resolving the ...
journal_title：Medical engineering & physics
pub_type： 杂志文章,评审
doi：10.1016/j.medengphy.2010.08.010
更新日期：2011-01-01 00:00:00
abstract：:A novel multi-scale simulation method developed to describe mesoscale phenomena occurring in biofluidic devices is presented. The approach combines the macro-scale modelling of the carrier fluid and the micro-scale description of the transported macromolecules or compounds. Application of the approach is demonstrated ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2010.08.003
更新日期：2011-09-01 00:00:00
abstract：:This paper describes a novel three-wire thermal flow sensor for medical applications. The present innovation for low-frequency measurements involves the use of a pulsed-wire anemometer with a comparatively large wire diameter (12.5 microm and larger) together with a novel signal processing approach. A small wire is he...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2004.06.002
更新日期：2004-10-01 00:00:00
abstract：:Accurate models of bone shapes are essential for orthopaedic reconstructions. The commonly used methods of using the contralateral side requires an intact bone and anatomical symmetry. Recent studies have shown that statistical shape and appearance models (SSAMs) as an alternative can predict accurate geometric models...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2019.03.007
更新日期：2019-05-01 00:00:00
abstract：:The impeller blood pump with its simplicity has many advantages compared with the diaphragm pump, but the nonpulsatile property has limited its applications. To make the impeller pump pulsatile, many investigations have been made in vain because of resulting haemolysis. The author has succeeded in producing a pulsatil...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/1350-4533(95)00010-0
更新日期：1996-01-01 00:00:00
